Genular: Defining Cellular Identity and Function

Details for: Srd5a1

Gene ID: 24950

Symbol: Srd5a1

Ensembl ID: ENSRNOG00000017601

Description: steroid 5 alpha-reductase 1

Associated with

Androgen biosynthesis
(R-RNO-193048)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of steroid hormones
(R-RNO-196071)
Metabolism of steroids
(R-RNO-8957322)
3-oxo-5-alpha-steroid 4-dehydrogenase activity
(GO:0003865)
3-oxo-5alpha-steroid 4-dehydrogenase (nadp+) activity
(GO:0047751)
Amide binding
(GO:0033218)
Androgen biosynthetic process
(GO:0006702)
Androgen catabolic process
(GO:0006710)
Androgen metabolic process
(GO:0008209)
Bone development
(GO:0060348)
Cell body fiber
(GO:0070852)
Cell differentiation
(GO:0030154)
Cellular response to camp
(GO:0071320)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to starvation
(GO:0009267)
Cellular response to testosterone stimulus
(GO:0071394)
Cerebral cortex development
(GO:0021987)
Diterpenoid metabolic process
(GO:0016101)
Endoplasmic reticulum membrane
(GO:0005789)
Female genitalia development
(GO:0030540)
Hippocampus development
(GO:0021766)
Hypothalamus development
(GO:0021854)
Liver development
(GO:0001889)
Male genitalia development
(GO:0030539)
Male gonad development
(GO:0008584)
Male sex differentiation
(GO:0046661)
Nadph binding
(GO:0070402)
Neuronal cell body
(GO:0043025)
Perinuclear region of cytoplasm
(GO:0048471)
Pituitary gland development
(GO:0021983)
Progesterone metabolic process
(GO:0042448)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Response to follicle-stimulating hormone
(GO:0032354)
Response to fungicide
(GO:0060992)
Response to growth hormone
(GO:0060416)
Response to muscle activity
(GO:0014850)
Response to organic cyclic compound
(GO:0014070)
Response to testosterone
(GO:0033574)
Response to xenobiotic stimulus
(GO:0009410)
Serotonin metabolic process
(GO:0042428)
Spinal cord development
(GO:0021510)
Steroid biosynthetic process
(GO:0006694)
Thalamus development
(GO:0021794)
Urogenital system development
(GO:0001655)

Other Information

Proteins

SR type 1
A6JV19_RAT

Genular Protein ID: 2587023895

Symbol: S5A1_RAT

Name: SR type 1

UniProtKB Accession Codes:

P24008 A0JPJ6

Database IDs:

Citations:

PubMed ID: 2476440

Title: Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation.

PubMed ID: 2476440

DOI: 10.1016/s0021-9258(18)71614-1

PubMed ID: 8597599

Title: Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone.

PubMed ID: 8597599

DOI: 10.1016/0167-4781(95)00198-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2339109

Title: Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

PubMed ID: 2339109

DOI: 10.1073/pnas.87.10.3640

Sequence Information:

Length: 259
Mass: 29780
Checksum: FE6705AC1D7CAE11
Sequence:

MVPLMELDEL CLLDMLVYLE GFMAFVSIVG LRSVGSPYGR YSPQWPGIRV PARPAWFIQE 
LPSMAWPLYE YIRPAAARLG NLPNRVLLAM FLIHYVQRTL VFPVLIRGGK PTLLVTFVLA 
FLFCTFNGYV QSRYLSQFAV YAEDWVTHPC FLTGFALWLV GMVINIHSDH ILRNLRKPGE 
TGYKIPRGGL FEYVSAANYF GELVEWCGFA LASWSLQGVV FALFTLSTLL TRAKQHHQWY 
HEKFEDYPKS RKILIPFVL

Genular Protein ID: 1171074073

Symbol: A6JV19_RAT

Name: N/A

UniProtKB Accession Codes:

A6JV19

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 255
Mass: 29339
Checksum: A8510DF4235CB9CA
Sequence:

MELDELCLLD MLVYLEGFMA FVSIVGLRSV GSPYGRYSPQ WPGIRVPARP AWFIQELPSM 
AWPLYEYIRP AAARLGNLPN RVLLAMFLIH YVQRTLVFPV LIRGGKPTLL VTFVLAFLFC 
TFNGYVQSRY LSQFAVYAED WVTHPCFLTG FALWLVGMVI NIHSDHILRN LRKPGETGYK 
IPRGGLFEYV SAANYFGELV EWCGFALASW SLQGVVFALF TLSTLLTRAK QHHQWYHEKF 
EDYPKSRKIL IPFVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Srd5a1

Associated with

Other Information

Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. PubMed ID: 2476440

Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone. PubMed ID: 8597599

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334