Genular: Defining Cellular Identity and Function

Details for: Insr

Gene ID: 24954

Symbol: Insr

Ensembl ID: ENSRNOG00000029986

Description: insulin receptor

Associated with

Insulin receptor recycling
(R-RNO-77387)
Insulin receptor signalling cascade
(R-RNO-74751)
Intracellular signaling by second messengers
(R-RNO-9006925)
Irs activation
(R-RNO-74713)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Signal attenuation
(R-RNO-74749)
Signaling by insulin receptor
(R-RNO-74752)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
3-phosphoinositide-dependent protein kinase binding
(GO:0043423)
Adrenal gland development
(GO:0030325)
Amyloid-beta binding
(GO:0001540)
Animal organ morphogenesis
(GO:0009887)
Atp binding
(GO:0005524)
Cargo receptor activity
(GO:0038024)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to zinc ion starvation
(GO:0034224)
Cerebellum development
(GO:0021549)
Epidermis development
(GO:0008544)
Exocrine pancreas development
(GO:0031017)
Fat cell differentiation
(GO:0045444)
Glucose homeostasis
(GO:0042593)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtp binding
(GO:0005525)
Heart morphogenesis
(GO:0003007)
Hippocampus development
(GO:0021766)
Identical protein binding
(GO:0042802)
Insulin-like growth factor i binding
(GO:0031994)
Insulin-like growth factor ii binding
(GO:0031995)
Insulin-like growth factor receptor binding
(GO:0005159)
Insulin binding
(GO:0043559)
Insulin receptor activity
(GO:0005009)
Insulin receptor signaling pathway
(GO:0008286)
Insulin receptor substrate binding
(GO:0043560)
Lipoic acid binding
(GO:0031405)
Liver development
(GO:0001889)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Multicellular organism development
(GO:0007275)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glycogen biosynthetic process
(GO:0045719)
Negative regulation of protein phosphorylation
(GO:0001933)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphorylation
(GO:0016310)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of glycogen biosynthetic process
(GO:0045725)
Positive regulation of glycoprotein biosynthetic process
(GO:0010560)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein-containing complex disassembly
(GO:0043243)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase activity
(GO:0004713)
Ptb domain binding
(GO:0051425)
Receptor-mediated endocytosis
(GO:0006898)
Receptor internalization
(GO:0031623)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of hydrogen peroxide metabolic process
(GO:0010310)
Response to activity
(GO:0014823)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to food
(GO:0032094)
Response to glucose
(GO:0009749)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to manganese ion
(GO:0010042)
Response to nutrient levels
(GO:0031667)
Response to organic substance
(GO:0010033)
Response to starvation
(GO:0042594)
Response to testosterone
(GO:0033574)
Response to tumor necrosis factor
(GO:0034612)
Response to vitamin d
(GO:0033280)
Structural molecule activity
(GO:0005198)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

A0A9K3Y780_RAT

Genular Protein ID: 1209790735

Symbol: A0A9K3Y780_RAT

Name: N/A

UniProtKB Accession Codes:

A0A9K3Y780

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

PubMed ID: 24023717

Title: Mapping of Mcs30, a New Mammary Carcinoma Susceptibility Quantitative Trait Locus (QTL30) on Rat Chromosome 12: Identification of Fry as a Candidate Mcs Gene.

PubMed ID: 24023717

Sequence Information:

Length: 1384
Mass: 156896
Checksum: 5FD2B0F942CBB2A9
Sequence:

MGSGRGCETT AVPLLMAVAA LLVGTAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL 
QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL 
VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN YIVLNKDDNE 
ECGDVCPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHKECL 
GNCSEPDDPT KCVACRNFYL DGQCVETCPP PYYHFQDWRC VNFSFCQDLH YKCRNSRKPG 
CHQYVIHNNK CIPECPSGYT MNSSNLMCTP CLGPCPKVCQ ILEGEKTIDS VTSAQELRGC 
TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGFLKIRRS YALVSLSFFR KLHLIRGETL 
EIGNYSFYAL DNQNLRQLWD WNKHNLTITQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE 
RNDIALKTNG DQASCENELL KFSFIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ 
NVTEFDGQDA CGSNSWTVVD IDPPQRSNDP KSQTPSHPGW LMRGLKPWTQ YAIFVKTLVT 
FSDERRTYGA KSDIIYVQTD ATNPSVPLDP ISVSNSSSQI ILKWKPPSDP NGNITHYLVY 
WERQAEDSEL FELDYCLKGL KLPSRTWSPP FESDDSQKHN QSEYDDSASE CCSCPKTDSQ 
ILKELEESSF RKTFEDYLHN VVFVPRKTSS GNGAEDTRPS RKRRSLEEVG NVTATTPTLP 
DFPNISSTIA PTSHEEHRPF EKVVNKESLV ISGLRHFTGY RIELQACNQD SPEERCSVAA 
YVSARTMPEA KADDIVGPVT HEIFENNVVH LMWQEPKEPN GLIVLYEVSY RRYGDEELHL 
CVSRKHFALE RGCRLRGLSP GNYSVRVRAT SLAGNGSWTE PTYFYVTDYL DVPSNIAKII 
IGPLIFVFLF SVVIGSIYLF LRKRQPDGPM GPLYASSNPE YLSASDVFPS SVYVPDEWEV 
PREKITLLRE LGQGSFGMVY EGNAKDIIKG EVETRVAVKT VNESASLRER IEFLNEASVM 
KGFTCHHVVR LLGVVSKGQP TLVVMELMAH GDLKSHLRSL RPDAENNPGR PPPTLQEMIQ 
MTAEIADGMA YLNAKKFVHR DLAARNCMVA HDFTVKIGDF GMTRDIYETD YYRKGGKGLL 
PVRWMSPESL KDGVFTASSD MWSFGVVLWE ITSLAEQPYQ GLSNEQVLKF VMDGGYLDPP 
DNCPERLTDL MRMCWQFNPK MRPTFLEIVN LLKDDLHPSF PEVSFFYSEE NKAPESEELE 
MEFEDMENVP LDRSSHCQRE EAGCREGGSS LSIKRTYDEH IPYTHMNGGK KNGRVLTLPR 
SNPS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.