Genular: Defining Cellular Identity and Function

Details for: Psmb8

Gene ID: 24968

Symbol: Psmb8

Ensembl ID: ENSRNOG00000000456

Description: proteasome 20S subunit beta 8

Associated with

Abc-family proteins mediated transport
(R-RNO-382556)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-RNO-176814)
Activation of nf-kappab in b cells
(R-RNO-1169091)
Adaptive immune system
(R-RNO-1280218)
Antigen processing-cross presentation
(R-RNO-1236975)
Antigen processing: ubiquitination & proteasome degradation
(R-RNO-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-RNO-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-RNO-174178)
Assembly of the pre-replicative complex
(R-RNO-68867)
Asymmetric localization of pcp proteins
(R-RNO-4608870)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-RNO-450408)
Autodegradation of cdh1 by cdh1:apc/c
(R-RNO-174084)
Beta-catenin independent wnt signaling
(R-RNO-3858494)
C-type lectin receptors (clrs)
(R-RNO-5621481)
Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
Cell cycle checkpoints
(R-RNO-69620)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to chemical stress
(R-RNO-9711123)
Cellular response to hypoxia
(R-RNO-1234174)
Class i mhc mediated antigen processing & presentation
(R-RNO-983169)
Clec7a (dectin-1) signaling
(R-RNO-5607764)
Cross-presentation of soluble exogenous antigens (endosomes)
(R-RNO-1236978)
Cyclin a:cdk2-associated events at s phase entry
(R-RNO-69656)
Cyclin e associated events during g1/s transition
(R-RNO-69202)
Cytokine signaling in immune system
(R-RNO-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-RNO-5607761)
Degradation of axin
(R-RNO-4641257)
Degradation of beta-catenin by the destruction complex
(R-RNO-195253)
Degradation of dvl
(R-RNO-4641258)
Degradation of gli1 by the proteasome
(R-RNO-5610780)
Deubiquitination
(R-RNO-5688426)
Dna replication
(R-RNO-69306)
Dna replication pre-initiation
(R-RNO-69002)
Downstream signaling events of b cell receptor (bcr)
(R-RNO-1168372)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-RNO-8854050)
G1/s dna damage checkpoints
(R-RNO-69615)
G1/s transition
(R-RNO-69206)
G2/m checkpoints
(R-RNO-69481)
G2/m transition
(R-RNO-69275)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Gli3 is processed to gli3r by the proteasome
(R-RNO-5610785)
Hedgehog 'off' state
(R-RNO-5610787)
Hedgehog 'on' state
(R-RNO-5632684)
Hedgehog ligand biogenesis
(R-RNO-5358346)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Intracellular signaling by second messengers
(R-RNO-9006925)
Keap1-nfe2l2 pathway
(R-RNO-9755511)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk6/mapk4 signaling
(R-RNO-5687128)
Mapk family signaling cascades
(R-RNO-5683057)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Metabolism of polyamines
(R-RNO-351202)
Metabolism of proteins
(R-RNO-392499)
Metabolism of rna
(R-RNO-8953854)
Mitotic anaphase
(R-RNO-68882)
Mitotic g1 phase and g1/s transition
(R-RNO-453279)
Mitotic g2-g2/m phases
(R-RNO-453274)
Mitotic metaphase and anaphase
(R-RNO-2555396)
M phase
(R-RNO-68886)
Neddylation
(R-RNO-8951664)
Nik-->noncanonical nf-kb signaling
(R-RNO-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-RNO-1234176)
P53-dependent g1 dna damage response
(R-RNO-69563)
P53-dependent g1/s dna damage checkpoint
(R-RNO-69580)
P53-independent dna damage response
(R-RNO-69610)
P53-independent g1/s dna damage checkpoint
(R-RNO-69613)
Pcp/ce pathway
(R-RNO-4086400)
Pip3 activates akt signaling
(R-RNO-1257604)
Post-translational protein modification
(R-RNO-597592)
Pten regulation
(R-RNO-6807070)
Raf/map kinase cascade
(R-RNO-5673001)
Regulation of apc/c activators between g1/s and early anaphase
(R-RNO-176408)
Regulation of mitotic cell cycle
(R-RNO-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-RNO-450531)
Regulation of ornithine decarboxylase (odc)
(R-RNO-350562)
Regulation of ras by gaps
(R-RNO-5658442)
Regulation of runx3 expression and activity
(R-RNO-8941858)
Rna polymerase ii transcription
(R-RNO-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-RNO-8939236)
Signaling by hedgehog
(R-RNO-5358351)
Signaling by the b cell receptor (bcr)
(R-RNO-983705)
Signaling by wnt
(R-RNO-195721)
Signal transduction
(R-RNO-162582)
S phase
(R-RNO-69242)
Switching of origins to a post-replicative state
(R-RNO-69052)
Synthesis of dna
(R-RNO-69239)
Tcf dependent signaling in response to wnt
(R-RNO-201681)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-RNO-8852276)
Tnfr2 non-canonical nf-kb pathway
(R-RNO-5668541)
Transcriptional regulation by runx1
(R-RNO-8878171)
Transcriptional regulation by runx3
(R-RNO-8878159)
Transport of small molecules
(R-RNO-382551)
Ub-specific processing proteases
(R-RNO-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-RNO-75815)
Uch proteinases
(R-RNO-5689603)

Other Information

Proteins

Proteasome subunit beta type-8

Genular Protein ID: 581422027

Symbol: PSB8_RAT

Name: Proteasome subunit beta type-8

UniProtKB Accession Codes:

P28064 Q6MGA4

Database IDs:

Citations:

PubMed ID: 15060004

Title: The genomic sequence and comparative analysis of the rat major histocompatibility complex.

PubMed ID: 15060004

DOI: 10.1101/gr.1987704

PubMed ID: 1451788

Title: cDNA cloning of rat proteasome subunit RC1, a homologue of RING10 located in the human MHC class II region.

PubMed ID: 1451788

DOI: 10.1016/0014-5793(92)80211-x

PubMed ID: 16988215

Title: Differential expression of genes encoding constitutive and inducible 20S proteasomal core subunits in the testis and epididymis of theophylline- or 1,3-dinitrobenzene-exposed rats.

PubMed ID: 16988215

DOI: 10.1095/biolreprod.106.053173

Sequence Information:

Length: 276
Mass: 30570
Checksum: 0955C80D2F969A97
Sequence:

MALLDLCGAP RGQRPEWAAV DAGSGLRSDP GHYSFSVQAP ELALPRGMQP TEFLRSFGDD 
QERKVQIEMA HGTTTLAFKF QHGVIVAVDS RASAGSYIAT IRVNKVIEIN PYLLGTMSGC 
AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMML QYRGMGLSMG SMICGWDKKG 
PGLYYVDDNG TRLSGQMFST GSGNTYAYGV MDSGYRQDLS PEEAYDLARR AIVYATHRDS 
YSGGVVNMYH MKKDGWVKVE STDVSDLLHK YREATL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.