Details for: RT1 A2

Gene ID: 24974

Symbol: RT1 A2

Description: RT1 class Ia, locus A2

Associated with

  • Adaptive immune response
    (GO:0002250)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib
    (GO:0002476)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway, tap-dependent
    (GO:0002489)
  • Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-independent
    (GO:0002486)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ib
    (GO:0002477)
  • Beta-2-microglobulin binding
    (GO:0030881)
  • Cd8-positive, alpha-beta t cell activation
    (GO:0036037)
  • Cell surface
    (GO:0009986)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular space
    (GO:0005615)
  • Immune response
    (GO:0006955)
  • Inner ear development
    (GO:0048839)
  • Lumenal side of endoplasmic reticulum membrane
    (GO:0098553)
  • Mhc class ib protein complex
    (GO:0032398)
  • Mhc class i protein binding
    (GO:0042288)
  • Mhc class i protein complex
    (GO:0042612)
  • Natural killer cell lectin-like receptor binding
    (GO:0046703)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Peptide antigen binding
    (GO:0042605)
  • Phagocytic vesicle membrane
    (GO:0030670)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of antibody-dependent cellular cytotoxicity
    (GO:0001815)
  • Positive regulation of cd8-positive, alpha-beta t cell activation
    (GO:2001187)
  • Positive regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000566)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell cytokine production
    (GO:0002729)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of natural killer cell mediated immunity
    (GO:0002717)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of trail production
    (GO:0032759)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protection from natural killer cell mediated cytotoxicity
    (GO:0042270)
  • Protein binding
    (GO:0005515)
  • Regulation of natural killer cell mediated immunity
    (GO:0002715)
  • Signaling receptor binding
    (GO:0005102)
  • T cell mediated cytotoxicity
    (GO:0001913)
  • T cell receptor binding
    (GO:0042608)

Other Information

Genular Protein ID: 2373859224

Symbol: Q6MGB8_RAT

Name: N/A

UniProtKB Accession Codes:

Q6MGB8 F7ERG5

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 6 GO 40 Gene3D 2 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PaxDb 1 Pfam 3 RGD 2 Reactome 6 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SMR 1 SUPFAM 2 TreeFam 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15060004

Title: The genomic sequence and comparative analysis of the rat major histocompatibility complex.

PubMed ID: 15060004

DOI: 10.1101/gr.1987704

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29531166

Title: Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats.

PubMed ID: 29531166

Sequence Information:

  • Length: 366
  • Mass: 41393
  • Checksum: 92AD4D9EF21F1974
  • Sequence:
    • MMEPCTLLLL LAVALTPTQT RAGSHSLRYF VTAVSRPGLG EPRYMEVGYV DDTQFVRYDS 
DAENPRYEPR APWMEREGPE YWERETQNAK RNEQVYRVDL RTALRYYNQS EGGSHTIQRM 
YGCDMGSDGS LLRGYYQDAY DGRDYIALNE DLKTWTAADF AAQITRSKWD QAGVAERLRA 
YLEGTCVEWL RRYLELGKET LLRSDPPEAH VTLHPRPEGD VTLRCWALGF YPADITLTWQ 
LNGEDLTQDM ELVETRPAGD GTFQKWASVV VPLGKEQNYT CRVEHEGLPE PLSQRWEPSP 
STNSNMETTV IYVVLGAIIG TLAIIGIVVA VVRKRRRNTG GKGDYTPAPG RDSSQSSDVS 
LPDCKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.