Details for: ABL1
Associated with
Other Information
Genular Protein ID: 3708582933
Symbol: ABL1_HUMAN
Name: Tyrosine-protein kinase ABL1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3021337
Title: Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
PubMed ID: 3021337
PubMed ID: 2687768
Title: Nucleotide sequence analysis of human abl and bcr-abl cDNAs.
PubMed ID: 2687768
PubMed ID: 7665185
Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
PubMed ID: 7665185
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2825022
Title: A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.
PubMed ID: 2825022
DOI: 10.1038/330386a0
PubMed ID: 6191223
Title: Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
PubMed ID: 6191223
DOI: 10.1038/304167a0
PubMed ID: 7545908
Title: Sequence analysis of the mutation at codon 834 and the sequence variation of codon 837 of c-abl gene.
PubMed ID: 7545908
PubMed ID: 2542016
Title: N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
PubMed ID: 2542016
PubMed ID: 2183353
Title: Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
PubMed ID: 2183353
PubMed ID: 9037071
Title: Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
PubMed ID: 9037071
PubMed ID: 9144171
Title: Protein binding and signaling properties of RIN1 suggest a unique effector function.
PubMed ID: 9144171
PubMed ID: 9461559
Title: Regulation of Rad51 function by c-Abl in response to DNA damage.
PubMed ID: 9461559
PubMed ID: 10194451
Title: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
PubMed ID: 10194451
PubMed ID: 10391250
Title: Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.
PubMed ID: 10391250
DOI: 10.1038/21697
PubMed ID: 10325413
Title: The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA.
PubMed ID: 10325413
PubMed ID: 11114745
Title: Regulation of cell death by the Abl tyrosine kinase.
PubMed ID: 11114745
PubMed ID: 11374898
Title: Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
PubMed ID: 11374898
PubMed ID: 12379650
Title: Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.
PubMed ID: 12379650
PubMed ID: 11971963
Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
PubMed ID: 11971963
PubMed ID: 12475393
Title: Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
PubMed ID: 12475393
DOI: 10.1042/bj20021539
PubMed ID: 12531427
Title: c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.
PubMed ID: 12531427
PubMed ID: 12672821
Title: Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
PubMed ID: 12672821
PubMed ID: 12775773
Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
PubMed ID: 12775773
DOI: 10.1242/jcs.00622
PubMed ID: 15302586
Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
PubMed ID: 15302586
PubMed ID: 15556646
Title: Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
PubMed ID: 15556646
PubMed ID: 15031292
Title: The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
PubMed ID: 15031292
PubMed ID: 15686624
Title: Role of c-Abl in the DNA damage stress response.
PubMed ID: 15686624
PubMed ID: 15886098
Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
PubMed ID: 15886098
PubMed ID: 15657060
Title: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
PubMed ID: 15657060
PubMed ID: 15696159
Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
PubMed ID: 15696159
DOI: 10.1038/ncb1228
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16648821
Title: c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.
PubMed ID: 16648821
PubMed ID: 16912036
Title: Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
PubMed ID: 16912036
PubMed ID: 16943190
Title: Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
PubMed ID: 16943190
PubMed ID: 16678104
Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
PubMed ID: 16678104
PubMed ID: 17306540
Title: A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
PubMed ID: 17306540
PubMed ID: 17623672
Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
PubMed ID: 17623672
PubMed ID: 18161990
Title: Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
PubMed ID: 18161990
DOI: 10.1021/bi701533j
PubMed ID: 18328268
Title: Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.
PubMed ID: 18328268
PubMed ID: 18945674
Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
PubMed ID: 18945674
PubMed ID: 18775435
Title: Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
PubMed ID: 18775435
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18182299
Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
PubMed ID: 18182299
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19891780
Title: Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases.
PubMed ID: 19891780
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19381274
Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
PubMed ID: 19381274
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20417104
Title: c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.
PubMed ID: 20417104
PubMed ID: 20861316
Title: Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.
PubMed ID: 20861316
PubMed ID: 20841568
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
PubMed ID: 20841568
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23006999
Title: Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.
PubMed ID: 23006999
PubMed ID: 22810897
Title: Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.
PubMed ID: 22810897
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28428613
Title: Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
PubMed ID: 28428613
PubMed ID: 1505033
Title: Three-dimensional solution structure of the src homology 2 domain of c-abl.
PubMed ID: 1505033
PubMed ID: 1281542
Title: Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.
PubMed ID: 1281542
PubMed ID: 7892170
PubMed ID: 8590002
Title: The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
PubMed ID: 8590002
PubMed ID: 9698566
Title: Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.
PubMed ID: 9698566
PubMed ID: 12384576
Title: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
PubMed ID: 12384576
PubMed ID: 12654251
Title: Structural basis for the autoinhibition of c-Abl tyrosine kinase.
PubMed ID: 12654251
PubMed ID: 16424036
Title: Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
PubMed ID: 16424036
PubMed ID: 16543148
Title: Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
PubMed ID: 16543148
PubMed ID: 16640460
Title: A Src-like inactive conformation in the abl tyrosine kinase domain.
PubMed ID: 16640460
PubMed ID: 17164530
Title: Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
PubMed ID: 17164530
PubMed ID: 17452790
Title: Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.
PubMed ID: 17452790
PubMed ID: 19906645
Title: Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
PubMed ID: 19906645
PubMed ID: 20357770
Title: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
PubMed ID: 20357770
DOI: 10.1038/nsmb.1793
PubMed ID: 15361874
Title: Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
PubMed ID: 15361874
DOI: 10.1038/ng1425
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 28288113
Title: Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
PubMed ID: 28288113
DOI: 10.1038/ng.3815
Sequence Information:
- Length: 1130
- Mass: 122873
- Checksum: 85FE6C1C0E483EA2
- Sequence:
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTVYGVSP NYDKWEMERT DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVNAVVL LYMATQISSA MEYLEKKNFI HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP SDRPSFAEIH QAFETMFQES SISDEVEKEL GKQGVRGAVS TLLQAPELPT KTRTSRRAAE HRDTTDVPEM PHSKGQGESD PLDHEPAVSP LLPRKERGPP EGGLNEDERL LPKDKKTNLF SALIKKKKKT APTPPKRSSS FREMDGQPER RGAGEEEGRD ISNGALAFTP LDTADPAKSP KPSNGAGVPN GALRESGGSG FRSPHLWKKS STLTSSRLAT GEEEGGGSSS KRFLRSCSAS CVPHGAKDTE WRSVTLPRDL QSTGRQFDSS TFGGHKSEKP ALPRKRAGEN RSDQVTRGTV TPPPRLVKKN EEAADEVFKD IMESSPGSSP PNLTPKPLRR QVTVAPASGL PHKEEAGKGS ALGTPAAAEP VTPTSKAGSG APGGTSKGPA EESRVRRHKH SSESPGRDKG KLSRLKPAPP PPPAASAGKA GGKPSQSPSQ EAAGEAVLGA KTKATSLVDA VNSDAAKPSQ PGEGLKKPVL PATPKPQSAK PSGTPISPAP VPSTLPSASS ALAGDQPSST AFIPLISTRV SLRKTRQPPE RIASGAITKG VVLDSTEALC LAISRNSEQM ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK FAFREAINKL ENNLRELQIC PATAGSGPAA TQDFSKLLSS VKEISDIVQR
Genular Protein ID: 1912702577
Symbol: Q59FK4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1167
- Mass: 127257
- Checksum: F05C6B7355BE8945
- Sequence:
PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS RHGGPHCNVF VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS TVADGLITTL HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI ITEFMTYGNL LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD LAARNCLVGE NHLVKVADFG LSRLMTGDTY TAHAGAKFPI KWTAPESLAY NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI DLSQVYELLE KDYRMERPEG CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS DEVEKELGKQ GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT PPKRSSSFRE MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS NGAGVPNGAL RESGGSGFRS PHLWKKSSTL TSSRLATGEE EGGGSSSKRF LRSCSASCVP HGAKDTEWRS VTLPRDLQST GRQFDSSTFG GHKSEKPALP RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME SSPGSSPPNL TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK PSQSPSQEAA GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT PKPQSAKPSG TPISPAPVPS TLPSASSALA GDQPSSTAFI PLISTRVSLR KTRQPPERIA SGAITKGVVL DSTEALCLAI SRNSEQMASH SAVLEAGKNL YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT AGSGPAATQD FSKLLSSVKE ISDIVQR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.