Details for: ABL1

Gene ID: 25

Symbol: ABL1

Ensembl ID: ENSG00000097007

Description: ABL proto-oncogene 1, non-receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 339.1940
    Cell Significance Index: -52.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.3490
    Cell Significance Index: -53.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 106.8535
    Cell Significance Index: -43.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.2619
    Cell Significance Index: -53.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.3776
    Cell Significance Index: -51.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.5462
    Cell Significance Index: -40.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6086
    Cell Significance Index: -53.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.6995
    Cell Significance Index: 72.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.5516
    Cell Significance Index: 54.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.2975
    Cell Significance Index: 44.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9384
    Cell Significance Index: 388.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8845
    Cell Significance Index: 144.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7969
    Cell Significance Index: 356.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7313
    Cell Significance Index: 97.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5476
    Cell Significance Index: 39.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4470
    Cell Significance Index: 235.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3138
    Cell Significance Index: 471.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2618
    Cell Significance Index: 1139.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.1835
    Cell Significance Index: 17.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0137
    Cell Significance Index: 701.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8702
    Cell Significance Index: 24.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7783
    Cell Significance Index: 22.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7343
    Cell Significance Index: 72.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7287
    Cell Significance Index: 10.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6762
    Cell Significance Index: 41.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6152
    Cell Significance Index: 36.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5265
    Cell Significance Index: 334.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5202
    Cell Significance Index: 23.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4698
    Cell Significance Index: 31.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4187
    Cell Significance Index: 190.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4141
    Cell Significance Index: 15.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3792
    Cell Significance Index: 583.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3783
    Cell Significance Index: 51.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3783
    Cell Significance Index: 697.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3610
    Cell Significance Index: 679.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3349
    Cell Significance Index: 9.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2816
    Cell Significance Index: 19.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1870
    Cell Significance Index: 33.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1733
    Cell Significance Index: 21.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1522
    Cell Significance Index: 28.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1511
    Cell Significance Index: 205.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0997
    Cell Significance Index: 2.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0910
    Cell Significance Index: 1.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0663
    Cell Significance Index: 2.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0637
    Cell Significance Index: 28.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0597
    Cell Significance Index: 32.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0482
    Cell Significance Index: -35.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0501
    Cell Significance Index: -36.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0652
    Cell Significance Index: -49.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0672
    Cell Significance Index: -11.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0863
    Cell Significance Index: -48.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0932
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0952
    Cell Significance Index: -59.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1283
    Cell Significance Index: -16.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1394
    Cell Significance Index: -20.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1565
    Cell Significance Index: -45.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1974
    Cell Significance Index: -23.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2014
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2704
    Cell Significance Index: -56.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2719
    Cell Significance Index: -7.7600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2919
    Cell Significance Index: -2.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2998
    Cell Significance Index: -30.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3047
    Cell Significance Index: -39.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3190
    Cell Significance Index: -33.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3269
    Cell Significance Index: -37.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3366
    Cell Significance Index: -4.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3770
    Cell Significance Index: -44.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3839
    Cell Significance Index: -8.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3904
    Cell Significance Index: -18.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4284
    Cell Significance Index: -19.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4870
    Cell Significance Index: -3.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5184
    Cell Significance Index: -26.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5380
    Cell Significance Index: -40.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5417
    Cell Significance Index: -34.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5847
    Cell Significance Index: -46.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6239
    Cell Significance Index: -39.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6461
    Cell Significance Index: -39.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6489
    Cell Significance Index: -45.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7443
    Cell Significance Index: -38.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7996
    Cell Significance Index: -41.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8217
    Cell Significance Index: -17.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8254
    Cell Significance Index: -20.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8321
    Cell Significance Index: -20.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8361
    Cell Significance Index: -12.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8769
    Cell Significance Index: -28.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8876
    Cell Significance Index: -28.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9638
    Cell Significance Index: -16.1300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9902
    Cell Significance Index: -15.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0080
    Cell Significance Index: -26.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0385
    Cell Significance Index: -15.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0469
    Cell Significance Index: -36.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1023
    Cell Significance Index: -22.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1075
    Cell Significance Index: -13.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1181
    Cell Significance Index: -39.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1267
    Cell Significance Index: -16.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.1489
    Cell Significance Index: -14.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2154
    Cell Significance Index: -26.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2277
    Cell Significance Index: -24.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2422
    Cell Significance Index: -20.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ABL1 gene is a proto-oncogene that encodes a non-receptor tyrosine kinase. It is a member of the ABL family of tyrosine kinases, which are characterized by their ability to phosphorylate tyrosine residues on target proteins. The ABL1 protein is a 120-kDa protein that is composed of four immunoglobulin-like domains and a catalytic domain. It is a dimeric protein that is activated by phosphorylation of its tyrosine residues. **Pathways and Functions** The ABL1 gene is involved in several signaling pathways, including: 1. **Rho GTPase signaling pathway**: The ABL1 protein is a key component of the Rho GTPase signaling pathway, which regulates cell migration, proliferation, and differentiation. 2. **NF-κB signaling pathway**: The ABL1 protein is also involved in the NF-κB signaling pathway, which regulates inflammation, immune response, and cell survival. 3. **MAPK signaling pathway**: The ABL1 protein is a key component of the MAPK signaling pathway, which regulates cell proliferation, differentiation, and survival. 4. **Autophagy**: The ABL1 protein is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins. 5. **Cell cycle regulation**: The ABL1 protein is involved in the regulation of the cell cycle, including the G1/S transition and mitosis. **Clinical Significance** The ABL1 gene has been implicated in various diseases, including: 1. **Cancer**: Mutations or overexpression of the ABL1 gene have been implicated in several types of cancer, including chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and breast cancer. 2. **Leishmania infection**: The ABL1 protein is involved in the regulation of Leishmania infection, a parasitic disease that affects millions of people worldwide. 3. **Hematological disorders**: The ABL1 gene is involved in the regulation of hematopoiesis, the process by which blood cells are produced. 4. **Neurological disorders**: The ABL1 protein is involved in the regulation of neurogenesis, the process by which new neurons are generated in the brain. In conclusion, the ABL1 gene is a critical component of various signaling pathways that regulate cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including cancer, Leishmania infection, and hematological disorders. Further research is needed to fully understand the role of the ABL1 gene in human disease.

Genular Protein ID: 3708582933

Symbol: ABL1_HUMAN

Name: Tyrosine-protein kinase ABL1

UniProtKB Accession Codes:

P00519 A3KFJ3 Q13869 Q13870 Q16133 Q17R61 Q45F09

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 4 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EC 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 81 PDBsum 81 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3021337

Title: Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.

PubMed ID: 3021337

DOI: 10.1016/0092-8674(86)90450-2

PubMed ID: 2687768

Title: Nucleotide sequence analysis of human abl and bcr-abl cDNAs.

PubMed ID: 2687768

PubMed ID: 7665185

Title: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.

PubMed ID: 7665185

DOI: 10.1006/geno.1995.1008

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2825022

Title: A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.

PubMed ID: 2825022

DOI: 10.1038/330386a0

PubMed ID: 6191223

Title: Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.

PubMed ID: 6191223

DOI: 10.1038/304167a0

PubMed ID: 7545908

Title: Sequence analysis of the mutation at codon 834 and the sequence variation of codon 837 of c-abl gene.

PubMed ID: 7545908

PubMed ID: 2542016

Title: N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

PubMed ID: 2542016

DOI: 10.1002/j.1460-2075.1989.tb03397.x

PubMed ID: 2183353

Title: Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.

PubMed ID: 2183353

DOI: 10.1126/science.2183353

PubMed ID: 9037071

Title: Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.

PubMed ID: 9037071

DOI: 10.1073/pnas.94.4.1437

PubMed ID: 9144171

Title: Protein binding and signaling properties of RIN1 suggest a unique effector function.

PubMed ID: 9144171

DOI: 10.1073/pnas.94.10.4954

PubMed ID: 9461559

Title: Regulation of Rad51 function by c-Abl in response to DNA damage.

PubMed ID: 9461559

DOI: 10.1074/jbc.273.7.3799

PubMed ID: 10194451

Title: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.

PubMed ID: 10194451

PubMed ID: 10391250

Title: Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.

PubMed ID: 10391250

DOI: 10.1038/21697

PubMed ID: 10325413

Title: The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA.

PubMed ID: 10325413

DOI: 10.1093/nar/27.11.2265

PubMed ID: 11114745

Title: Regulation of cell death by the Abl tyrosine kinase.

PubMed ID: 11114745

DOI: 10.1038/sj.onc.1203878

PubMed ID: 11374898

Title: Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.

PubMed ID: 11374898

DOI: 10.1006/geno.2001.6541

PubMed ID: 12379650

Title: Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.

PubMed ID: 12379650

DOI: 10.1074/jbc.m208151200

PubMed ID: 11971963

Title: c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.

PubMed ID: 11971963

DOI: 10.1128/mcb.22.10.3292-3300.2002

PubMed ID: 12475393

Title: Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.

PubMed ID: 12475393

DOI: 10.1042/bj20021539

PubMed ID: 12531427

Title: c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.

PubMed ID: 12531427

DOI: 10.1016/s0898-6568(02)00090-6

PubMed ID: 12672821

Title: Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.

PubMed ID: 12672821

DOI: 10.1074/jbc.m301447200

PubMed ID: 12775773

Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.

PubMed ID: 12775773

DOI: 10.1242/jcs.00622

PubMed ID: 15302586

Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

PubMed ID: 15302586

DOI: 10.1016/j.yexcr.2004.05.010

PubMed ID: 15556646

Title: Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.

PubMed ID: 15556646

DOI: 10.1016/j.febslet.2004.10.054

PubMed ID: 15031292

Title: The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

PubMed ID: 15031292

DOI: 10.1074/jbc.m311479200

PubMed ID: 15686624

Title: Role of c-Abl in the DNA damage stress response.

PubMed ID: 15686624

DOI: 10.1038/sj.cr.7290261

PubMed ID: 15886098

Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

PubMed ID: 15886098

DOI: 10.1016/j.cub.2005.03.049

PubMed ID: 15657060

Title: c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.

PubMed ID: 15657060

DOI: 10.1074/jbc.m413787200

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16648821

Title: c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.

PubMed ID: 16648821

DOI: 10.1038/sj.embor.7400700

PubMed ID: 16912036

Title: Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.

PubMed ID: 16912036

DOI: 10.1074/jbc.m605902200

PubMed ID: 16943190

Title: Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.

PubMed ID: 16943190

DOI: 10.1074/jbc.m603126200

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 17306540

Title: A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.

PubMed ID: 17306540

DOI: 10.1016/j.cub.2007.01.057

PubMed ID: 17623672

Title: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.

PubMed ID: 17623672

DOI: 10.1074/jbc.m701484200

PubMed ID: 18161990

Title: Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.

PubMed ID: 18161990

DOI: 10.1021/bi701533j

PubMed ID: 18328268

Title: Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.

PubMed ID: 18328268

DOI: 10.1016/j.bbamcr.2008.01.028

PubMed ID: 18945674

Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.

PubMed ID: 18945674

DOI: 10.1074/jbc.m804543200

PubMed ID: 18775435

Title: Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.

PubMed ID: 18775435

DOI: 10.1016/j.jmb.2008.08.040

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18182299

Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.

PubMed ID: 18182299

DOI: 10.1016/j.tibs.2007.10.006

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19891780

Title: Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases.

PubMed ID: 19891780

DOI: 10.1186/1471-2121-10-80

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20417104

Title: c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.

PubMed ID: 20417104

DOI: 10.1016/j.cub.2010.03.048

PubMed ID: 20861316

Title: Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

PubMed ID: 20861316

DOI: 10.1091/mbc.e09-10-0876

PubMed ID: 20841568

Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.

PubMed ID: 20841568

DOI: 10.1126/scisignal.3139re6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23006999

Title: Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.

PubMed ID: 23006999

DOI: 10.1016/j.bbamcr.2012.09.003

PubMed ID: 22810897

Title: Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.

PubMed ID: 22810897

DOI: 10.1126/scisignal.2002632

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28428613

Title: Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

PubMed ID: 28428613

DOI: 10.1038/s41598-017-00800-w

PubMed ID: 1505033

Title: Three-dimensional solution structure of the src homology 2 domain of c-abl.

PubMed ID: 1505033

DOI: 10.1016/0092-8674(92)90437-h

PubMed ID: 1281542

Title: Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.

PubMed ID: 1281542

DOI: 10.1073/pnas.89.24.11673

PubMed ID: 7892170

Title: Homology modeling of the Abl-SH3 domain.

PubMed ID: 7892170

DOI: 10.1002/prot.340200302

PubMed ID: 8590002

Title: The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.

PubMed ID: 8590002

DOI: 10.1016/s0969-2126(01)00243-x

PubMed ID: 9698566

Title: Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.

PubMed ID: 9698566

DOI: 10.1006/jmbi.1998.1932

PubMed ID: 12384576

Title: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.

PubMed ID: 12384576

DOI: 10.1073/pnas.212518799

PubMed ID: 12654251

Title: Structural basis for the autoinhibition of c-Abl tyrosine kinase.

PubMed ID: 12654251

DOI: 10.1016/s0092-8674(03)00194-6

PubMed ID: 16424036

Title: Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

PubMed ID: 16424036

DOI: 10.1158/0008-5472.can-05-2788

PubMed ID: 16543148

Title: Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.

PubMed ID: 16543148

DOI: 10.1016/j.molcel.2006.01.035

PubMed ID: 16640460

Title: A Src-like inactive conformation in the abl tyrosine kinase domain.

PubMed ID: 16640460

DOI: 10.1371/journal.pbio.0040144

PubMed ID: 17164530

Title: Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.

PubMed ID: 17164530

DOI: 10.1107/s0907444906047287

PubMed ID: 17452790

Title: Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.

PubMed ID: 17452790

DOI: 10.1107/s0907444907011109

PubMed ID: 19906645

Title: Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.

PubMed ID: 19906645

DOI: 10.1074/jbc.m109.048033

PubMed ID: 20357770

Title: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.

PubMed ID: 20357770

DOI: 10.1038/nsmb.1793

PubMed ID: 15361874

Title: Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.

PubMed ID: 15361874

DOI: 10.1038/ng1425

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 28288113

Title: Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.

PubMed ID: 28288113

DOI: 10.1038/ng.3815

Sequence Information:

  • Length: 1130
  • Mass: 122873
  • Checksum: 85FE6C1C0E483EA2
  • Sequence:
    • MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE 
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN 
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS 
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTVYGVSP NYDKWEMERT 
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ 
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVNAVVL LYMATQISSA MEYLEKKNFI 
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS 
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP 
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKQGVRGAVS TLLQAPELPT KTRTSRRAAE 
HRDTTDVPEM PHSKGQGESD PLDHEPAVSP LLPRKERGPP EGGLNEDERL LPKDKKTNLF 
SALIKKKKKT APTPPKRSSS FREMDGQPER RGAGEEEGRD ISNGALAFTP LDTADPAKSP 
KPSNGAGVPN GALRESGGSG FRSPHLWKKS STLTSSRLAT GEEEGGGSSS KRFLRSCSAS 
CVPHGAKDTE WRSVTLPRDL QSTGRQFDSS TFGGHKSEKP ALPRKRAGEN RSDQVTRGTV 
TPPPRLVKKN EEAADEVFKD IMESSPGSSP PNLTPKPLRR QVTVAPASGL PHKEEAGKGS 
ALGTPAAAEP VTPTSKAGSG APGGTSKGPA EESRVRRHKH SSESPGRDKG KLSRLKPAPP 
PPPAASAGKA GGKPSQSPSQ EAAGEAVLGA KTKATSLVDA VNSDAAKPSQ PGEGLKKPVL 
PATPKPQSAK PSGTPISPAP VPSTLPSASS ALAGDQPSST AFIPLISTRV SLRKTRQPPE 
RIASGAITKG VVLDSTEALC LAISRNSEQM ASHSAVLEAG KNLYTFCVSY VDSIQQMRNK 
FAFREAINKL ENNLRELQIC PATAGSGPAA TQDFSKLLSS VKEISDIVQR

Genular Protein ID: 1912702577

Symbol: Q59FK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FK4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 4 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 2 Rhea 3 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1167
  • Mass: 127257
  • Checksum: F05C6B7355BE8945
  • Sequence:
    • PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS RHGGPHCNVF 
VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT 
KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS 
GINGSFLVRE SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS 
TVADGLITTL HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK 
YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI ITEFMTYGNL 
LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD LAARNCLVGE NHLVKVADFG 
LSRLMTGDTY TAHAGAKFPI KWTAPESLAY NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI 
DLSQVYELLE KDYRMERPEG CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS 
DEVEKELGKQ GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD 
HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT PPKRSSSFRE 
MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS NGAGVPNGAL RESGGSGFRS 
PHLWKKSSTL TSSRLATGEE EGGGSSSKRF LRSCSASCVP HGAKDTEWRS VTLPRDLQST 
GRQFDSSTFG GHKSEKPALP RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME 
SSPGSSPPNL TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG 
GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK PSQSPSQEAA 
GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT PKPQSAKPSG TPISPAPVPS 
TLPSASSALA GDQPSSTAFI PLISTRVSLR KTRQPPERIA SGAITKGVVL DSTEALCLAI 
SRNSEQMASH SAVLEAGKNL YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT 
AGSGPAATQD FSKLLSSVKE ISDIVQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.