Details for: ALPP

Gene ID: 250

Symbol: ALPP

Ensembl ID: ENSG00000163283

Description: alkaline phosphatase, placental

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8283
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.08
    Marker Score: 32741
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3181
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.66
    Marker Score: 971
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10812
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.35
    Marker Score: 2556
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.24
    Marker Score: 7546
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.11
    Marker Score: 2261
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32728.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.99
    Marker Score: 322
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.87
    Marker Score: 524
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12536.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3452.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 206
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.37
    Marker Score: 12802.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.25
    Marker Score: 299
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 490
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 198
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.06
    Marker Score: 158
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 15.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.06
    Marker Score: 13.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.06
    Marker Score: 15.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.04
    Marker Score: 228
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 12.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 507
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.04
    Marker Score: 29.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 12.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.03
    Marker Score: 54
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.03
    Marker Score: 478
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 15.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 12.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.02
    Marker Score: 74
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.02
    Marker Score: 989
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.02
    Marker Score: 8.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.02
    Marker Score: 12.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.02
    Marker Score: 44
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 820
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 45
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 11.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 13.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.01
    Marker Score: 15.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 44
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 12

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Other Information

**Key characteristics:** * The ALPP gene is located on chromosome 15q21.1. * It is a large gene with a length of approximately 10.5 kb. * It contains 17 exons and 16 introns. * The protein encoded by ALPP is a glycoprotein with a molecular weight of approximately 150 kDa. **Pathways and functions:** * ALPP is involved in multiple cellular processes, including cell surface signaling, dephosphorylation, and membrane trafficking. * It is a key regulator of cell adhesion, migration, and differentiation. * It is also involved in the regulation of calcium and magnesium ion signaling pathways. * ALPP has been linked to a number of human diseases, including cerebral palsy, epilepsy, and developmental disorders. **Clinical significance:** * Mutations in the ALPP gene have been linked to a number of human diseases, including cerebral palsy, epilepsy, and developmental disorders. * ALPP inhibitors are currently being investigated as potential treatments for these diseases. * Understanding the role of ALPP in human health is important for developing new therapeutic strategies. **Additional information:** * The ALPP gene is also known as PPB1. * It is expressed in a variety of cell types, including endothelial cells, neurons, and immune cells. * It is a highly conserved gene, with a similar protein found in other mammals.

Genular Protein ID: 3168680542

Symbol: PPB1_HUMAN

Name: Alkaline phosphatase, placental type

UniProtKB Accession Codes:

P05187 P05188 P06861 Q53S78 Q96DB7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3042787

Title: Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.

PubMed ID: 3042787

DOI: 10.1016/s0021-9258(18)37887-6

PubMed ID: 3512548

Title: Molecular cloning and sequence analysis of human placental alkaline phosphatase.

PubMed ID: 3512548

DOI: 10.1016/s0021-9258(17)35755-1

PubMed ID: 3461452

Title: Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.

PubMed ID: 3461452

DOI: 10.1073/pnas.83.15.5597

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3001717

Title: Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.

PubMed ID: 3001717

DOI: 10.1073/pnas.82.24.8715

PubMed ID: 6651840

Title: Purification and partial sequencing of human placental alkaline phosphatase.

PubMed ID: 6651840

DOI: 10.1016/s0006-291x(83)80252-6

PubMed ID: 3459156

Title: Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.

PubMed ID: 3459156

DOI: 10.1073/pnas.83.11.3781

PubMed ID: 3422741

Title: Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.

PubMed ID: 3422741

DOI: 10.1073/pnas.85.5.1398

PubMed ID: 2153284

Title: Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.

PubMed ID: 2153284

DOI: 10.1073/pnas.87.1.157

PubMed ID: 1939159

Title: Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.

PubMed ID: 1939159

DOI: 10.1016/s0021-9258(18)54836-5

PubMed ID: 1730777

Title: Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.

PubMed ID: 1730777

DOI: 10.1083/jcb.116.3.799

PubMed ID: 11937510

Title: Function assignment to conserved residues in mammalian alkaline phosphatases.

PubMed ID: 11937510

DOI: 10.1074/jbc.m202298200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 25775211

Title: Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

PubMed ID: 25775211

DOI: 10.1371/journal.pone.0119874

PubMed ID: 11124260

Title: Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.

PubMed ID: 11124260

DOI: 10.1074/jbc.m009250200

PubMed ID: 15946677

Title: Structural studies of human placental alkaline phosphatase in complex with functional ligands.

PubMed ID: 15946677

DOI: 10.1016/j.jmb.2005.04.068

PubMed ID: 16815919

Title: Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones.

PubMed ID: 16815919

DOI: 10.1110/ps.062123806

PubMed ID: 20693656

Title: Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.

PubMed ID: 20693656

DOI: 10.1107/s1744309110019767

Sequence Information:

  • Length: 535
  • Mass: 57954
  • Checksum: 13C136679A70C76B
  • Sequence:
    • MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNREAAE ALGAAKKLQP AQTAAKNLII 
FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA 
YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG 
TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP 
DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI 
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL TETIMFDDAI 
ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG 
YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI 
AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP

Genular Protein ID: 195624628

Symbol: B2R7C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R7C7

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 16 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 RuleBase 2 SAM 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 535
  • Mass: 57854
  • Checksum: EEB12EED89A2C6A4
  • Sequence:
    • MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNRQAAE ALGAAKKLQP AQTAAKNLII 
FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA 
YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG 
TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP 
DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI 
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYGAL TETIMFDDAI 
ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG 
YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI 
AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.