Details for: ALPP

Gene ID: 250

Symbol: ALPP

Ensembl ID: ENSG00000163283

Description: alkaline phosphatase, placental

Associated with

Other Information

Genular Protein ID: 3168680542

Symbol: PPB1_HUMAN

Name: Alkaline phosphatase, placental type

UniProtKB Accession Codes:

P05187 P05188 P06861 Q53S78 Q96DB7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3042787

Title: Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.

PubMed ID: 3042787

DOI: 10.1016/s0021-9258(18)37887-6

PubMed ID: 3512548

Title: Molecular cloning and sequence analysis of human placental alkaline phosphatase.

PubMed ID: 3512548

DOI: 10.1016/s0021-9258(17)35755-1

PubMed ID: 3461452

Title: Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.

PubMed ID: 3461452

DOI: 10.1073/pnas.83.15.5597

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3001717

Title: Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.

PubMed ID: 3001717

DOI: 10.1073/pnas.82.24.8715

PubMed ID: 6651840

Title: Purification and partial sequencing of human placental alkaline phosphatase.

PubMed ID: 6651840

DOI: 10.1016/s0006-291x(83)80252-6

PubMed ID: 3459156

Title: Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.

PubMed ID: 3459156

DOI: 10.1073/pnas.83.11.3781

PubMed ID: 3422741

Title: Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.

PubMed ID: 3422741

DOI: 10.1073/pnas.85.5.1398

PubMed ID: 2153284

Title: Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.

PubMed ID: 2153284

DOI: 10.1073/pnas.87.1.157

PubMed ID: 1939159

Title: Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.

PubMed ID: 1939159

DOI: 10.1016/s0021-9258(18)54836-5

PubMed ID: 1730777

Title: Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.

PubMed ID: 1730777

DOI: 10.1083/jcb.116.3.799

PubMed ID: 11937510

Title: Function assignment to conserved residues in mammalian alkaline phosphatases.

PubMed ID: 11937510

DOI: 10.1074/jbc.m202298200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 25775211

Title: Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

PubMed ID: 25775211

DOI: 10.1371/journal.pone.0119874

PubMed ID: 11124260

Title: Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.

PubMed ID: 11124260

DOI: 10.1074/jbc.m009250200

PubMed ID: 15946677

Title: Structural studies of human placental alkaline phosphatase in complex with functional ligands.

PubMed ID: 15946677

DOI: 10.1016/j.jmb.2005.04.068

PubMed ID: 16815919

Title: Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones.

PubMed ID: 16815919

DOI: 10.1110/ps.062123806

PubMed ID: 20693656

Title: Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.

PubMed ID: 20693656

DOI: 10.1107/s1744309110019767

Sequence Information:

  • Length: 535
  • Mass: 57954
  • Checksum: 13C136679A70C76B
  • Sequence:
    • MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNREAAE ALGAAKKLQP AQTAAKNLII 
FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA 
YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG 
TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP 
DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI 
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYRAL TETIMFDDAI 
ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG 
YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI 
AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP

Genular Protein ID: 195624628

Symbol: B2R7C7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R7C7

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 16 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 RuleBase 2 SAM 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 535
  • Mass: 57854
  • Checksum: EEB12EED89A2C6A4
  • Sequence:
    • MLGPCMLLLL LLLGLRLQLS LGIIPVEEEN PDFWNRQAAE ALGAAKKLQP AQTAAKNLII 
FLGDGMGVST VTAARILKGQ KKDKLGPEIP LAMDRFPYVA LSKTYNVDKH VPDSGATATA 
YLCGVKGNFQ TIGLSAAARF NQCNTTRGNE VISVMNRAKK AGKSVGVVTT TRVQHASPAG 
TYAHTVNRNW YSDADVPASA RQEGCQDIAT QLISNMDIDV ILGGGRKYMF RMGTPDPEYP 
DDYSQGGTRL DGKNLVQEWL AKRQGARYVW NRTELMQASL DPSVTHLMGL FEPGDMKYEI 
HRDSTLDPSL MEMTEAALRL LSRNPRGFFL FVEGGRIDHG HHESRAYGAL TETIMFDDAI 
ERAGQLTSEE DTLSLVTADH SHVFSFGGYP LRGSSIFGLA PGKARDRKAY TVLLYGNGPG 
YVLKDGARPD VTESESGSPE YRQQSAVPLD EETHAGEDVA VFARGPQAHL VHGVQEQTFI 
AHVMAFAACL EPYTACDLAP PAGTTDAAHP GRSVVPALLP LLAGTLLLLE TATAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.