Details for: Cyp2d2

Gene ID: 25053

Symbol: Cyp2d2

Ensembl ID: ENSRNOG00000008988

Description: cytochrome P450, family 2, subfamily d, polypeptide 2

Associated with

  • Arachidonic acid metabolic process
    (GO:0019369)
  • Aromatase activity
    (GO:0070330)
  • Cytoplasm
    (GO:0005737)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Female pregnancy
    (GO:0007565)
  • Heme binding
    (GO:0020037)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Iron ion binding
    (GO:0005506)
  • Membrane
    (GO:0016020)
  • Monooxygenase activity
    (GO:0004497)
  • Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    (GO:0016705)
  • Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    (GO:0016712)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Xenobiotic metabolic process
    (GO:0006805)

Other Information

Genular Protein ID: 1377247082

Symbol: CP2DQ_RAT

Name: Cytochrome P450 2D26

UniProtKB Accession Codes:

P10634

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 EC 2 EMBL 5 Ensembl 4 GO 12 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3582092

Title: Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.

PubMed ID: 3582092

DOI: 10.1089/dna.1987.6.149

PubMed ID: 2819073

Title: The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats.

PubMed ID: 2819073

DOI: 10.1021/bi00444a030

PubMed ID: 3190674

Title: Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily.

PubMed ID: 3190674

DOI: 10.1016/s0006-291x(88)80896-9

PubMed ID: 2107330

Title: The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.

PubMed ID: 2107330

DOI: 10.1007/bf02099942

PubMed ID: 9434752

Title: Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity.

PubMed ID: 9434752

DOI: 10.1006/abbi.1997.0402

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 500
  • Mass: 56684
  • Checksum: 23E99250734C2215
  • Sequence:
    • MGLLIGDDLW AVVIFTAIFL LLVDLVHRHK FWTAHYPPGP VPLPGLGNLL QVDFENMPYS 
LYKLRSRYGD VFSLQIAWKP VVVINGLKAV RELLVTYGED TADRPLLPIY NHLGYGNKSK 
GVVLAPYGPE WREQRRFSVS TLRDFGVGKK SLEQWVTEEA GHLCDTFAKE AEHPFNPSIL 
LSKAVSNVIA SLVYARRFEY EDPFFNRMLK TLKESFGEDT GFMAEVLNAI PILLQIPGLP 
GKVFPKLNSF IALVDKMLIE HKKSWDPAQP PRDMTDAFLA EMQKAKGNPE SSFNDENLRL 
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHEEIDE VIGQVRRPEM ADQARMPFTN 
AVIHEVQRFA DIVPTNIPHM TSRDIKFQGF LIPKGTTLIP NLSSVLKDET VWEKPLRFHP 
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VLAGRPRPST 
HGVYALPVTP QPYQLCAVAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.