Genular: Defining Cellular Identity and Function

Details for: Hk2

Gene ID: 25059

Symbol: Hk2

Ensembl ID: ENSRNOG00000006116

Description: hexokinase 2

Associated with

Glucose metabolism
(R-RNO-70326)
Glycolysis
(R-RNO-70171)
Metabolism
(R-RNO-1430728)
Metabolism of carbohydrates
(R-RNO-71387)
Apoptotic mitochondrial changes
(GO:0008637)
Atp binding
(GO:0005524)
Carbohydrate phosphorylation
(GO:0046835)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Centrosome
(GO:0005813)
Cytosol
(GO:0005829)
Establishment of protein localization to mitochondrion
(GO:0072655)
Fructokinase activity
(GO:0008865)
Fructose 6-phosphate metabolic process
(GO:0006002)
Glucokinase activity
(GO:0004340)
Glucose 6-phosphate metabolic process
(GO:0051156)
Glucose binding
(GO:0005536)
Glucose catabolic process
(GO:0006007)
Glucose metabolic process
(GO:0006006)
Glycolytic process
(GO:0006096)
Hexokinase activity
(GO:0004396)
Hexose metabolic process
(GO:0019318)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular membrane-bounded organelle
(GO:0043231)
Lactation
(GO:0007595)
Maintenance of protein location in mitochondrion
(GO:0072656)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of mitochondrial membrane permeability
(GO:0035795)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
(GO:1904925)
Regulation of glucose import
(GO:0046324)
Response to hypoxia
(GO:0001666)
Response to ischemia
(GO:0002931)
Sarcoplasmic reticulum
(GO:0016529)

Other Information

Proteins

HXK2_RAT

Genular Protein ID: 1648301142

Symbol: HXK2_RAT

Name: N/A

UniProtKB Accession Codes:

P27881 Q9QWR1

Database IDs:

Citations:

PubMed ID: 1897984

Title: Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor.

PubMed ID: 1897984

DOI: 10.1016/0003-9861(91)90094-y

PubMed ID: 7873617

Title: Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene.

PubMed ID: 7873617

DOI: 10.1016/0167-4781(94)00226-s

PubMed ID: 7622509

Title: Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.

PubMed ID: 7622509

DOI: 10.1074/jbc.270.28.16918

PubMed ID: 5871820

Title: Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver.

PubMed ID: 5871820

DOI: 10.1016/0006-291x(64)90038-5

PubMed ID: 7044667

Title: The comparative isozymology of vertebrate hexokinases.

PubMed ID: 7044667

DOI: 10.1016/0305-0491(82)90461-8

Sequence Information:

Length: 917
Mass: 102544
Checksum: 764EC189C0F90987
Sequence:

MIASHMIACL FTELNQNQVQ KVDQFLYHMR LSDETLLEIS RRFRKEMEKG LGATTHPTAA 
VKMLPTFVRS TPDGTEHGEF LALDLGGTNF RVLRVRVTDN GLQRVEMENQ IYAIPEDIMR 
GSGTQLFDHI AECLANFMDK LQIKEKKLPL GFTFSFPCHQ TKLDESFLVS WTKGFKSSGV 
EGRDVVDLIR KAIQRRGDFD IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGSNACYME 
EMRHIDMVEG DEGRMCINME WGAFGDDGTL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM 
YMGELVRLIL VKMAKAELLF QGKLSPELLT TGSFETKDVS DIEEDKDGIE KAYQILMRLG 
LNPLQEDCVA THRICQIVST RSASLCAATL AAVLWRIKEN KGEERLRSTI GVDGSVYKKH 
PHFAKRLHKA VRRLVPDCDV RFLRSEDGSG KGAAMVTAVA YRLADQHRAR QKTLESLKLS 
HEQLLEVKRR MKVEMEQGLS KETHAVAPVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV 
LLVRVRNGKR RGVEMHNKIY SIPQEVMHGT GEELFDHIVQ CIADFLEYMG MKGVSLPLGF 
TFSFPCQQNS LDQSILLKWT KGFKASGCEG EDVVTLLKEA IHRREEFDLD VVAVVNDTVG 
TMMTCGYEDP HCEVGLIVGT GSNACYMEEM RNVELVDGEE GRMCVNMEWG AFGDNGCLDD 
LRTVFDVAVD ELSLNPGKQR FEKMISGMYL GEIVRNILID FTKRGLLFRG RISERLKTRG 
IFETKFLSQI ESDCLALLQV RAILRHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA 
VVDKIRENRG LDNLKVTVGV DGTLYKLHPH FAKVMHETVR DLAPKCDVSF LESEDGSGKG 
AALITAVACR IREAGQR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hk2

Associated with

Other Information

Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor. PubMed ID: 1897984

Nucleotide sequence of the 5'-flanking region of the rat type II hexokinase gene. PubMed ID: 7873617

Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. PubMed ID: 7622509