Genular: Defining Cellular Identity and Function

Details for: Adra2a

Gene ID: 25083

Symbol: Adra2a

Ensembl ID: ENSRNOG00000047545

Description: adrenoceptor alpha 2A

Associated with

Adrenaline,noradrenaline inhibits insulin secretion
(R-RNO-400042)
Adrenaline signalling through alpha-2 adrenergic receptor
(R-RNO-392023)
Adrenoceptors
(R-RNO-390696)
Amine ligand-binding receptors
(R-RNO-375280)
Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (i) signalling events
(R-RNO-418594)
G alpha (z) signalling events
(R-RNO-418597)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Hemostasis
(R-RNO-109582)
Integration of energy metabolism
(R-RNO-163685)
Metabolism
(R-RNO-1430728)
Metabolism of proteins
(R-RNO-392499)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet aggregation (plug formation)
(R-RNO-76009)
Regulation of insulin secretion
(R-RNO-422356)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Surfactant metabolism
(R-RNO-5683826)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-inhibiting adrenergic receptor signaling pathway
(GO:0071881)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adrenergic receptor activity
(GO:0004935)
Adrenergic receptor signaling pathway
(GO:0071875)
Alpha-1b adrenergic receptor binding
(GO:0031692)
Alpha-2c adrenergic receptor binding
(GO:0031696)
Alpha2-adrenergic receptor activity
(GO:0004938)
Axon terminus
(GO:0043679)
Cellular response to hormone stimulus
(GO:0032870)
Cytoplasm
(GO:0005737)
Dna replication
(GO:0006260)
Dopaminergic synapse
(GO:0098691)
Epinephrine binding
(GO:0051379)
Fear response
(GO:0042596)
Female pregnancy
(GO:0007565)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heterotrimeric g-protein binding
(GO:0032795)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of calcium ion transport
(GO:0051926)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061179)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of uterine smooth muscle contraction
(GO:0070473)
Neuronal cell body
(GO:0043025)
Norepinephrine binding
(GO:0051380)
Phospholipase c-activating adrenergic receptor signaling pathway
(GO:0071882)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of membrane protein ectodomain proteolysis
(GO:0051044)
Positive regulation of potassium ion transport
(GO:0043268)
Positive regulation of wound healing
(GO:0090303)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Receptor complex
(GO:0043235)
Regulation of vasoconstriction
(GO:0019229)
Thermoception
(GO:0050955)
Thioesterase binding
(GO:0031996)
Vasodilation
(GO:0042311)

Other Information

Proteins

Alpha-2A adrenoreceptor

Genular Protein ID: 4264966548

Symbol: ADA2A_RAT

Name: Alpha-2A adrenoreceptor

UniProtKB Accession Codes:

P22909 M0R9R3

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 2177834

Title: Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain.

PubMed ID: 2177834

DOI: 10.1007/bf00221058

PubMed ID: 1645350

Title: Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype.

PubMed ID: 1645350

DOI: 10.1016/s0021-9258(18)99248-3

PubMed ID: 7623790

Title: Structural, genetic and pharmacological identity of the rat alpha 2-adrenergic receptor subtype cA2-47 and its molecular characterization in rat adrenal, adrenocortical carcinoma and bovine retina.

PubMed ID: 7623790

DOI: 10.1007/bf00944398

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 465
Mass: 50630
Checksum: 50FDE09BC56F4C96
Sequence:

MFRQEQPLAE GSFAPMGSLQ PDAGNSSWNG TEAPGGGTRA TPYSLQVTLT LVCLAGLLML 
FTVFGNVLVI IAVFTSRALK APQNLFLVSL ASADILVATL VIPFSLANEV MGYWYFGKVW 
CEIYLALDVL FCTSSIVHLC AISLDRYWSI TQAIEYNLKR TPRRIKAIIV TVWVISAVIS 
FPPLISIEKK GAGGGQQPAE PSCKINDQKW YVISSSIGSF FAPCLIMILV YVRIYQIAKR 
RTRVPPSRRG PDACSAPPGG ADRRPNGLGP ERGAGTAGAE AEPLPTQLNG APGEPAPTRP 
RDGDALDLEE SSSSEHAERP QGPGKPERGP RAKGKTKASQ VKPGDSLPRR GPGAAGPGAS 
GSGQGEERAG GAKASRWRGR QNREKRFTFV LAVVIGVFVV CWFPFFFTYT LIAVGCPVPY 
QLFNFFFWFG YCNSSLNPVI YTIFNHDFRR AFKKILCRGD RKRIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Adra2a

Associated with

Other Information

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Molecular cloning, sequencing and expression of an alpha 2-adrenergic receptor complementary DNA from rat brain. PubMed ID: 2177834

Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype. PubMed ID: 1645350