Genular: Defining Cellular Identity and Function

Details for: Cyp2e1

Gene ID: 25086

Symbol: Cyp2e1

Ensembl ID: ENSRNOG00000012458

Description: cytochrome P450, family 2, subfamily e, polypeptide 1

Associated with

Aspirin adme
(R-RNO-9749641)
Biological oxidations
(R-RNO-211859)
Biosynthesis of dha-derived spms
(R-RNO-9018677)
Biosynthesis of maresin-like spms
(R-RNO-9027307)
Biosynthesis of maresins
(R-RNO-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-RNO-9018678)
Cyp2e1 reactions
(R-RNO-211999)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Drug adme
(R-RNO-9748784)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Paracetamol adme
(R-RNO-9753281)
Phase i - functionalization of compounds
(R-RNO-211945)
Xenobiotics
(R-RNO-211981)
4-nitrophenol 2-monooxygenase activity
(GO:0018601)
4-nitrophenol metabolic process
(GO:0018960)
Arachidonic acid epoxygenase activity
(GO:0008392)
Aromatase activity
(GO:0070330)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Epoxygenase p450 pathway
(GO:0019373)
Fatty acid metabolic process
(GO:0006631)
Golgi membrane
(GO:0000139)
Heme binding
(GO:0020037)
Heterocycle metabolic process
(GO:0046483)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Lipid hydroxylation
(GO:0002933)
Long-chain fatty acid metabolic process
(GO:0001676)
Long-chain fatty acid omega-1 hydroxylase activity
(GO:0120319)
Mitochondrial inner membrane
(GO:0005743)
Monooxygenase activity
(GO:0004497)
Monoterpenoid metabolic process
(GO:0016098)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Response to 3-methylcholanthrene
(GO:1904681)
Response to bacterium
(GO:0009617)
Response to ethanol
(GO:0045471)
Response to organonitrogen compound
(GO:0010243)
Response to ozone
(GO:0010193)
Response to xenobiotic stimulus
(GO:0009410)
Steroid metabolic process
(GO:0008202)
Triglyceride metabolic process
(GO:0006641)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 2E1

Genular Protein ID: 1541145217

Symbol: CP2E1_RAT

Name: Cytochrome P450 2E1

UniProtKB Accession Codes:

P05182

Database IDs:

Citations:

PubMed ID: 3782137

Title: Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PubMed ID: 3782137

DOI: 10.1016/s0021-9258(18)66620-7

PubMed ID: 2832413

Title: The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation.

PubMed ID: 2832413

DOI: 10.1016/s0021-9258(18)68880-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3308889

Title: Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes.

PubMed ID: 3308889

DOI: 10.1016/s0021-9258(18)47940-9

PubMed ID: 2321956

Title: Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation.

PubMed ID: 2321956

DOI: 10.1016/0003-9861(90)90245-t

PubMed ID: 1441586

Title: Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene.

PubMed ID: 1441586

DOI: 10.3109/00498259209053125

PubMed ID: 19401463

Title: Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

PubMed ID: 19401463

DOI: 10.1074/jbc.m109.007492

Sequence Information:

Length: 493
Mass: 56627
Checksum: 7600B9D28AED5EDB
Sequence:

MAVLGITIAL LVWVATLLVI SIWKQIYNSW NLPPGPFPLP ILGNIFQLDL KDIPKSFTKL 
AKRFGPVFTL HLGSRRIVVL HGYKAVKEVL LNHKNEFSGR GDIPVFQEYK NKGIIFNNGP 
TWKDVRRFSL SILRDWGMGK QGNEARIQRE AQFLVEELKK TKGQPFDPTF LIGCAPCNVI 
ADILFNKRFD YNDKKCLRLM SLFNENFYLL STPWIQLYNN FADYLRYLPG SHRKIMKNVS 
EIKQYTLEKA KEHLQSLDIN CARDVTDCLL IEMEKEKHSQ EPMYTMENVS VTLADLFFAG 
TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIGPSRVPA VRDRLDMPYM DAVVHEIQRF 
INLVPSNLPH EATRDTVFQG YVIPKGTVVI PTLDSLLYDS HEFPDPEKFK PEHFLNENGK 
FKYSDYFKAF SAGKRVCVGE GLARMELFLL LSAILQHFNL KSLVDPKDID LSPVTVGFGS 
IPPQFKLCVI PRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp2e1

Associated with

Other Information

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. PubMed ID: 3782137

The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. PubMed ID: 2832413

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Responses to insulin by two forms of rat hepatic microsomal cytochrome P-450 that undergo major (RLM6) and minor (RLM5b) elevations in diabetes. PubMed ID: 3308889

Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation. PubMed ID: 2321956

Molecular cloning of a cDNA for rat diabetes-inducible cytochrome P450RLM6: hormonal regulation and similarity to the cytochrome P4502E1 gene. PubMed ID: 1441586

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. PubMed ID: 19401463