Details for: Foxa1

Gene ID: 25098

Symbol: Foxa1

Ensembl ID: ENSRNOG00000009284

Description: forkhead box A1

Associated with

  • Esr-mediated signaling
    (R-RNO-8939211)
  • Estrogen-dependent gene expression
    (R-RNO-9018519)
  • Signaling by nuclear receptors
    (R-RNO-9006931)
  • Signal transduction
    (R-RNO-162582)
  • Alveolar secondary septum development
    (GO:0061144)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Cell differentiation
    (GO:0030154)
  • Chromatin binding
    (GO:0003682)
  • Chromatin organization
    (GO:0006325)
  • Chromatin remodeling
    (GO:0006338)
  • Connective tissue development
    (GO:0061448)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral neural tube patterning
    (GO:0021904)
  • Double-stranded dna binding
    (GO:0003690)
  • Epithelial cell maturation involved in prostate gland development
    (GO:0060743)
  • Epithelial tube branching involved in lung morphogenesis
    (GO:0060441)
  • Fibrillar center
    (GO:0001650)
  • Glucose homeostasis
    (GO:0042593)
  • Hormone metabolic process
    (GO:0042445)
  • Lung development
    (GO:0030324)
  • Lung epithelial cell differentiation
    (GO:0060487)
  • Lung morphogenesis
    (GO:0060425)
  • Mesenchymal-epithelial cell signaling involved in prostate gland development
    (GO:0060739)
  • Microvillus
    (GO:0005902)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate specification
    (GO:0048665)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dopaminergic neuron differentiation
    (GO:1904340)
  • Positive regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901300)
  • Positive regulation of intracellular estrogen receptor signaling pathway
    (GO:0033148)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland epithelium morphogenesis
    (GO:0060740)
  • Prostate gland stromal morphogenesis
    (GO:0060741)
  • Protein domain specific binding
    (GO:0019904)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory basal cell differentiation
    (GO:1902691)
  • Response to estradiol
    (GO:0032355)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
    (GO:0060528)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Tube morphogenesis
    (GO:0035239)

Other Information

Genular Protein ID: 4268287104

Symbol: FOXA1_RAT

Name: Hepatocyte nuclear factor 3-alpha

UniProtKB Accession Codes:

P23512

Database IDs:

AGR 1 AlphaFoldDB 1 CDD 1 CTD 1 EMBL 1 GO 52 Gene3D 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2227418

Title: HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

PubMed ID: 2227418

DOI: 10.1101/gad.4.8.1427

PubMed ID: 12750453

Title: The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes.

PubMed ID: 12750453

DOI: 10.1210/me.2003-0020

PubMed ID: 15358835

Title: Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding.

PubMed ID: 15358835

DOI: 10.1210/me.2004-0211

PubMed ID: 17189638

Title: Specific interactions of the wing domains of FOXA1 transcription factor with DNA.

PubMed ID: 17189638

DOI: 10.1016/j.jmb.2006.11.087

PubMed ID: 17220277

Title: Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.

PubMed ID: 17220277

DOI: 10.1128/mcb.01133-06

PubMed ID: 18178153

Title: Hepatocyte nuclear factor-3 alpha (HNF-3alpha) negatively regulates androgen receptor transactivation in prostate cancer cells.

PubMed ID: 18178153

DOI: 10.1016/j.bbrc.2007.12.162

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 466
  • Mass: 48775
  • Checksum: 06555BA74BD9B7DC
  • Sequence:
    • MLGTVKMEGH ESNDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT 
PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGAALSP GGMGSMGAQP 
AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT 
MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNACFVK VARSPDKPGK 
GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGSGG GGSKGVPENR KDPSGPVNPS 
AESPIHRGVH GKASQLEGAP APGPAASPQT LDHSGATATG GGSELKSPAS SSAPPISSGP 
GGWICTPLSP TWLAPHESQL HLKGAPHYSF NHPFSINNLM SSSEQQHKLD FKAYEQALQY 
SPYGATLPAS LPLGGASVAT RSPIEPSALE PAYYQGVYSR PVLNTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.