Genular: Defining Cellular Identity and Function

Details for: Foxa2

Gene ID: 25099

Symbol: Foxa2

Ensembl ID: ENSRNOG00000013133

Description: forkhead box A2

Associated with

Adult locomotory behavior
(GO:0008344)
Anatomical structure formation involved in morphogenesis
(GO:0048646)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior pattern specification
(GO:0009952)
Cell development
(GO:0048468)
Cell differentiation
(GO:0030154)
Cell differentiation in hindbrain
(GO:0021533)
Cell fate specification
(GO:0001708)
Cell junction
(GO:0030054)
Cellular response to cadmium ion
(GO:0071276)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Connective tissue development
(GO:0061448)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dopaminergic neuron differentiation
(GO:0071542)
Dorsal/ventral neural tube patterning
(GO:0021904)
Dorsal/ventral pattern formation
(GO:0009953)
Double-stranded dna binding
(GO:0003690)
Ectoderm formation
(GO:0001705)
Endocrine pancreas development
(GO:0031018)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Gene expression
(GO:0010467)
Glucose mediated signaling pathway
(GO:0010255)
In utero embryonic development
(GO:0001701)
Kinase binding
(GO:0019900)
Lung development
(GO:0030324)
Lung epithelial cell differentiation
(GO:0060487)
Mesendoderm development
(GO:0048382)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription from rna polymerase ii promoter by glucose
(GO:0061987)
Neuron differentiation
(GO:0030182)
Neuron fate specification
(GO:0048665)
Notch signaling pathway
(GO:0007219)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pattern specification process
(GO:0007389)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dopaminergic neuron differentiation
(GO:1904340)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of gastrulation
(GO:2000543)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription by rna polymerase iii
(GO:0045945)
Positive regulation of transcription from rna polymerase ii promoter by glucose
(GO:0000432)
Primitive streak formation
(GO:0090009)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of blood coagulation
(GO:0030193)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0061178)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of steroid metabolic process
(GO:0019218)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to insulin
(GO:0032868)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Smad binding
(GO:0046332)
Smoothened signaling pathway
(GO:0007224)
Somite rostral/caudal axis specification
(GO:0032525)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Hepatocyte nuclear factor 3-beta

Genular Protein ID: 2967097941

Symbol: FOXA2_RAT

Name: Hepatocyte nuclear factor 3-beta

UniProtKB Accession Codes:

P32182

Database IDs:

Citations:

PubMed ID: 1672118

Title: Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

PubMed ID: 1672118

DOI: 10.1101/gad.5.3.416

PubMed ID: 1324404

Title: Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.

PubMed ID: 1324404

DOI: 10.1128/mcb.12.9.3723-3732.1992

PubMed ID: 8139574

Title: The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

PubMed ID: 8139574

DOI: 10.1128/mcb.14.4.2755-2766.1994

PubMed ID: 7739897

Title: Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting.

PubMed ID: 7739897

DOI: 10.1093/nar/23.7.1184

PubMed ID: 10748198

Title: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

PubMed ID: 10748198

DOI: 10.1074/jbc.m910211199

PubMed ID: 10931833

Title: Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver.

PubMed ID: 10931833

DOI: 10.1074/jbc.m004027200

PubMed ID: 14500912

Title: Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

PubMed ID: 14500912

DOI: 10.1073/pnas.1931483100

PubMed ID: 19478084

Title: Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.

PubMed ID: 19478084

DOI: 10.1074/jbc.m109.016295

PubMed ID: 19589781

Title: Nuclear export-independent inhibition of Foxa2 by insulin.

PubMed ID: 19589781

DOI: 10.1074/jbc.m109.042135

Sequence Information:

Length: 458
Mass: 48484
Checksum: 9FF754142C194055
Sequence:

MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNASLGMNGM NTYMSMSAAA MGSGSGNMSA 
GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA 
MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML 
TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDFLKVP RAPDKPGKGS FWTLHPDSGN 
MFENGCYLRR QKRFKCENEL ALKEAAGAGS GGGKKTAPGT QASQVQLGEA AGSASETPAG 
TESPHSSASP CQEHKRGGLS ELKGTPASAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP 
EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKTYEQVMH YPGGYGSPMP 
GSLAMGPVTN KAGLDASPLA ADTSYYQGVY SRPIMNSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Foxa2

Associated with

Other Information

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. PubMed ID: 1672118

Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein. PubMed ID: 1324404

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. PubMed ID: 8139574

Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting. PubMed ID: 7739897

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. PubMed ID: 10748198

Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. PubMed ID: 10931833

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. PubMed ID: 14500912

Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2. PubMed ID: 19478084

Nuclear export-independent inhibition of Foxa2 by insulin. PubMed ID: 19589781