Details for: ALPG

Gene ID: 251

Symbol: ALPG

Ensembl ID: ENSG00000163286

Description: alkaline phosphatase, germ cell

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 6.98
    Marker Score: 4784
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.53
    Marker Score: 4360
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1517
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 2000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.92
    Marker Score: 2149
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.68
    Marker Score: 2179
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.41
    Marker Score: 823
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 876
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.2
    Marker Score: 1139
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 494
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7672
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4809
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 510
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 516
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 469
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 380
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1042.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 508
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1198
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 701
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 534
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1263
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 393
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1126
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.58
    Marker Score: 153
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.57
    Marker Score: 179
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.55
    Marker Score: 8561
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5
    Marker Score: 1023
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 440.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 252
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 385
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.38
    Marker Score: 13118.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2118
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 164
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 196
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.24
    Marker Score: 68
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.19
    Marker Score: 49.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 78
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.16
    Marker Score: 46.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.15
    Marker Score: 174
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 161
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.14
    Marker Score: 34.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 181
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.14
    Marker Score: 41.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 46.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 45.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 378
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.12
    Marker Score: 28.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 170
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 175
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1
    Marker Score: 501
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.07
    Marker Score: 49.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 146
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.05
    Marker Score: 45.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 601
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 28.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.03
    Marker Score: 35.5
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.03
    Marker Score: 46.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.03
    Marker Score: 64
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 78
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 46.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.03
    Marker Score: 41.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.03
    Marker Score: 48

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Other Information

**Key characteristics:** - The ALPG gene is located on chromosome 17q21.1. - It is a single copy gene. - It encodes a protein of 547 amino acids. - The protein is a transmembrane protein with a single extracellular domain and a single transmembrane domain. - The extracellular domain is responsible for binding to its substrates. - The transmembrane domain is responsible for the dephosphorylation activity of the protein. **Pathways and functions:** - The ALPG protein is involved in a variety of cellular processes, including cell migration, cell cycle regulation, and immune responses. - In dendritic cells, ALPG is essential for the migration of dendritic cells to their final destination in the lymph node. - In T cells, ALPG is involved in the regulation of T cell activation. - In conventional dendritic cells, ALPG is involved in the processing and presentation of antigens to T cells. **Clinical significance:** - Mutations in the ALPG gene have been linked to several human diseases, including liver disease, cancer, and autoimmune disorders. - In liver disease, ALPG mutations can lead to the accumulation of damaged proteins in the liver, which can damage liver cells and lead to disease. - In cancer, ALPG mutations can allow cancer cells to evade detection and destruction by the immune system. - In autoimmune disorders, ALPG mutations can lead to the production of autoantibodies that can damage tissues in the body.

Genular Protein ID: 1091653534

Symbol: PPBN_HUMAN

Name: ALP-1

UniProtKB Accession Codes:

P10696 A8KAF2 Q16727 Q53S81 Q96CM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 10 EPD 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2834730

Title: Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

PubMed ID: 2834730

DOI: 10.1073/pnas.85.9.3024

PubMed ID: 2745460

Title: Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells.

PubMed ID: 2745460

DOI: 10.1016/s0021-9258(18)63900-6

PubMed ID: 2297757

Title: Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells.

PubMed ID: 2297757

PubMed ID: 2162249

Title: Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.

PubMed ID: 2162249

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3443302

Title: Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.

PubMed ID: 3443302

DOI: 10.1016/0378-1119(87)90235-6

PubMed ID: 3387245

Title: 5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene.

PubMed ID: 3387245

DOI: 10.1093/nar/16.12.5694

PubMed ID: 1939159

Title: Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.

PubMed ID: 1939159

DOI: 10.1016/s0021-9258(18)54836-5

Sequence Information:

  • Length: 532
  • Mass: 57377
  • Checksum: 25EB56C901B61505
  • Sequence:
    • MQGPWVLLLL GLRLQLSLGI IPVEEENPDF WNRQAAEALG AAKKLQPAQT AAKNLIIFLG 
DGMGVSTVTA ARILKGQKKD KLGPETFLAM DRFPYVALSK TYSVDKHVPD SGATATAYLC 
GVKGNFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKKAGK SVGVVTTTRV QHASPAGAYA 
HTVNRNWYSD ADVPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPDDY 
SQGGTRLDGK NLVQEWLAKH QGARYVWNRT ELLQASLDPS VTHLMGLFEP GDMKYEIHRD 
STLDPSLMEM TEAALLLLSR NPRGFFLFVE GGRIDHGHHE SRAYRALTET IMFDDAIERA 
GQLTSEEDTL SLVTADHSHV FSFGGYPLRG SSIFGLAPGK ARDRKAYTVL LYGNGPGYVL 
KDGARPDVTE SESGSPEYRQ QSAVPLDGET HAGEDVAVFA RGPQAHLVHG VQEQTFIAHV 
MAFAACLEPY TACDLAPRAG TTDAAHPGPS VVPALLPLLA GTLLLLGTAT AP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.