Details for: ALPG

Gene ID: 251

Symbol: ALPG

Ensembl ID: ENSG00000163286

Description: alkaline phosphatase, germ cell

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3296
    Cell Significance Index: 180.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1330
    Cell Significance Index: 1.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0106
    Cell Significance Index: 1.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0086
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0072
    Cell Significance Index: 0.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0016
    Cell Significance Index: 0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0261
    Cell Significance Index: -19.7800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0371
    Cell Significance Index: -0.4700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0740
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0754
    Cell Significance Index: -1.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0768
    Cell Significance Index: -15.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0778
    Cell Significance Index: -10.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0853
    Cell Significance Index: -1.0200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0940
    Cell Significance Index: -1.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0942
    Cell Significance Index: -1.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0951
    Cell Significance Index: -1.2000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0960
    Cell Significance Index: -1.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1464
    Cell Significance Index: -29.3600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1496
    Cell Significance Index: -1.6400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1889
    Cell Significance Index: -1.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2028
    Cell Significance Index: -9.1900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2088
    Cell Significance Index: -1.8300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2173
    Cell Significance Index: -3.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2377
    Cell Significance Index: -2.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2882
    Cell Significance Index: -4.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3181
    Cell Significance Index: -3.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3336
    Cell Significance Index: -48.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3451
    Cell Significance Index: -5.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3708
    Cell Significance Index: -9.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4050
    Cell Significance Index: -10.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4072
    Cell Significance Index: -8.1200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.4784
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4915
    Cell Significance Index: -6.8200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5204
    Cell Significance Index: -6.1500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.5304
    Cell Significance Index: -4.0100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5831
    Cell Significance Index: -7.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5976
    Cell Significance Index: -6.8400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6167
    Cell Significance Index: -5.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6189
    Cell Significance Index: -8.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6886
    Cell Significance Index: -11.1500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6953
    Cell Significance Index: -9.5400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7055
    Cell Significance Index: -9.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7336
    Cell Significance Index: -49.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.7567
    Cell Significance Index: -9.9300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.7677
    Cell Significance Index: -8.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.7821
    Cell Significance Index: -10.1200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.7999
    Cell Significance Index: -9.9000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.8202
    Cell Significance Index: -9.6500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.8231
    Cell Significance Index: -10.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.8402
    Cell Significance Index: -10.7600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.8413
    Cell Significance Index: -9.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8445
    Cell Significance Index: -31.0000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.8618
    Cell Significance Index: -10.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9161
    Cell Significance Index: -11.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9247
    Cell Significance Index: -23.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.9444
    Cell Significance Index: -11.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.9620
    Cell Significance Index: -11.3700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -1.1091
    Cell Significance Index: -11.8500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.1224
    Cell Significance Index: -11.9200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -1.1464
    Cell Significance Index: -12.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.1588
    Cell Significance Index: -12.4300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -1.1772
    Cell Significance Index: -14.2100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -1.2122
    Cell Significance Index: -9.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.2290
    Cell Significance Index: -17.6000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.2768
    Cell Significance Index: -15.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3494
    Cell Significance Index: -28.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3767
    Cell Significance Index: -23.0400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -1.4714
    Cell Significance Index: -15.3100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.5262
    Cell Significance Index: -13.6400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -1.5842
    Cell Significance Index: -19.8400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -1.6223
    Cell Significance Index: -12.0700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -1.6644
    Cell Significance Index: -19.5700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -1.6977
    Cell Significance Index: -20.1800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -1.7184
    Cell Significance Index: -10.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7445
    Cell Significance Index: -46.5800
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -1.7655
    Cell Significance Index: -12.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.8210
    Cell Significance Index: -19.8400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -1.8686
    Cell Significance Index: -20.2600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -1.9205
    Cell Significance Index: -19.8100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -1.9814
    Cell Significance Index: -20.2100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -2.0111
    Cell Significance Index: -19.8400
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -2.0390
    Cell Significance Index: -11.9700
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -2.0870
    Cell Significance Index: -15.3200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -2.0977
    Cell Significance Index: -25.5200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -2.1113
    Cell Significance Index: -26.3800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -2.1299
    Cell Significance Index: -20.2300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -2.2124
    Cell Significance Index: -10.7600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -2.2564
    Cell Significance Index: -23.0500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -2.2625
    Cell Significance Index: -10.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -2.3141
    Cell Significance Index: -25.6300
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: -2.3182
    Cell Significance Index: -20.2800
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -2.3306
    Cell Significance Index: -22.8800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -2.3580
    Cell Significance Index: -25.5300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -2.3594
    Cell Significance Index: -14.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -2.3602
    Cell Significance Index: -31.0600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -2.3729
    Cell Significance Index: -26.3900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -2.3743
    Cell Significance Index: -25.5300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -2.3747
    Cell Significance Index: -31.0000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -2.3952
    Cell Significance Index: -15.2900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -2.4050
    Cell Significance Index: -26.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALPG is a member of the alkaline phosphatase family, characterized by its ability to catalyze the removal of phosphate groups from various substrates. The ALPG protein is primarily expressed in germ cells, including spermatocytes and oocytes, as well as in other cell types such as dendritic cells, T cells, and plasma cells. Its expression is also notable in enterocytes of the large intestine, colon goblet cells, and intestinal crypt stem cells of the small intestine. **Pathways and Functions:** ALPG is involved in several key pathways, including: 1. **Alkaline Phosphatase Activity:** ALPG's primary function is to catalyze the removal of phosphate groups from various substrates, including proteins, lipids, and nucleotides. 2. **Dephosphorylation:** ALPG is involved in the dephosphorylation of proteins, which regulates various cellular processes, including signal transduction, cell proliferation, and differentiation. 3. **Post-Translational Modification:** ALPG is required for the synthesis of GPI-anchored proteins, which play critical roles in cell-cell interactions, immune responses, and cell signaling. 4. **Metal Ion Binding:** ALPG binds to metal ions, such as zinc and magnesium, which are essential cofactors for its catalytic activity. **Clinical Significance:** The expression of ALPG in germ cells and other cell types has significant implications for our understanding of various diseases and disorders. For instance: 1. **Reproductive Health:** Abnormalities in ALPG expression have been linked to infertility, miscarriage, and other reproductive disorders. 2. **Immunological Disorders:** ALPG's role in regulating protein metabolism and post-translational modifications makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** Altered ALPG expression has been observed in various types of cancer, including leukemia, lymphoma, and solid tumors, suggesting its potential as a biomarker for cancer diagnosis and prognosis. In conclusion, the ALPG gene is a complex and multifaceted enzyme that plays a critical role in various cellular processes, including protein metabolism, post-translational modifications, and metal ion binding. Further research is necessary to fully elucidate the functions and clinical significance of ALPG, but its expression in germ cells and other cell types offers a promising avenue for the diagnosis and treatment of various diseases.

Genular Protein ID: 1091653534

Symbol: PPBN_HUMAN

Name: ALP-1

UniProtKB Accession Codes:

P10696 A8KAF2 Q16727 Q53S81 Q96CM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 1 EMBL 10 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2834730

Title: Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

PubMed ID: 2834730

DOI: 10.1073/pnas.85.9.3024

PubMed ID: 2745460

Title: Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells.

PubMed ID: 2745460

DOI: 10.1016/s0021-9258(18)63900-6

PubMed ID: 2297757

Title: Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells.

PubMed ID: 2297757

PubMed ID: 2162249

Title: Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.

PubMed ID: 2162249

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3443302

Title: Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.

PubMed ID: 3443302

DOI: 10.1016/0378-1119(87)90235-6

PubMed ID: 3387245

Title: 5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene.

PubMed ID: 3387245

DOI: 10.1093/nar/16.12.5694

PubMed ID: 1939159

Title: Mutation of a single amino acid converts germ cell alkaline phosphatase to placental alkaline phosphatase.

PubMed ID: 1939159

DOI: 10.1016/s0021-9258(18)54836-5

Sequence Information:

  • Length: 532
  • Mass: 57377
  • Checksum: 25EB56C901B61505
  • Sequence:
    • MQGPWVLLLL GLRLQLSLGI IPVEEENPDF WNRQAAEALG AAKKLQPAQT AAKNLIIFLG 
DGMGVSTVTA ARILKGQKKD KLGPETFLAM DRFPYVALSK TYSVDKHVPD SGATATAYLC 
GVKGNFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKKAGK SVGVVTTTRV QHASPAGAYA 
HTVNRNWYSD ADVPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPDDY 
SQGGTRLDGK NLVQEWLAKH QGARYVWNRT ELLQASLDPS VTHLMGLFEP GDMKYEIHRD 
STLDPSLMEM TEAALLLLSR NPRGFFLFVE GGRIDHGHHE SRAYRALTET IMFDDAIERA 
GQLTSEEDTL SLVTADHSHV FSFGGYPLRG SSIFGLAPGK ARDRKAYTVL LYGNGPGYVL 
KDGARPDVTE SESGSPEYRQ QSAVPLDGET HAGEDVAVFA RGPQAHLVHG VQEQTFIAHV 
MAFAACLEPY TACDLAPRAG TTDAAHPGPS VVPALLPLLA GTLLLLGTAT AP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.