Genular: Defining Cellular Identity and Function

Details for: Fgfr4

Gene ID: 25114

Symbol: Fgfr4

Ensembl ID: ENSRNOG00000016763

Description: fibroblast growth factor receptor 4

Associated with

Betaklotho-mediated ligand binding
(R-RNO-1307965)
Downstream signaling of activated fgfr4
(R-RNO-5654716)
Fgfr4 ligand binding and activation
(R-RNO-190322)
Frs-mediated fgfr4 signaling
(R-RNO-5654712)
Igf1r signaling cascade
(R-RNO-2428924)
Insulin receptor signalling cascade
(R-RNO-74751)
Intracellular signaling by second messengers
(R-RNO-9006925)
Irs-mediated signalling
(R-RNO-112399)
Irs-related events triggered by igf1r
(R-RNO-2428928)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Negative regulation of fgfr4 signaling
(R-RNO-5654733)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Phospholipase c-mediated cascade; fgfr4
(R-RNO-5654228)
Pi-3k cascade:fgfr4
(R-RNO-5654720)
Pi3k cascade
(R-RNO-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Raf/map kinase cascade
(R-RNO-5673001)
Shc-mediated cascade:fgfr4
(R-RNO-5654719)
Signaling by fgfr
(R-RNO-190236)
Signaling by fgfr4
(R-RNO-5654743)
Signaling by insulin receptor
(R-RNO-74752)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-RNO-2404192)
Signal transduction
(R-RNO-162582)
Alveolar secondary septum development
(GO:0061144)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cell migration
(GO:0016477)
Cholesterol homeostasis
(GO:0042632)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Fibroblast growth factor binding
(GO:0017134)
Fibroblast growth factor receptor activity
(GO:0005007)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Glucose homeostasis
(GO:0042593)
Golgi apparatus
(GO:0005794)
Heparin binding
(GO:0008201)
Lung development
(GO:0030324)
Multicellular organism development
(GO:0007275)
Negative regulation of fibroblast growth factor production
(GO:0090272)
Negative regulation of gene expression
(GO:0010629)
Organ induction
(GO:0001759)
Phosphate ion homeostasis
(GO:0055062)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of parathyroid hormone secretion
(GO:2000830)
Positive regulation of proteolysis
(GO:0045862)
Receptor complex
(GO:0043235)
Regulation of bile acid biosynthetic process
(GO:0070857)
Regulation of extracellular matrix disassembly
(GO:0010715)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of phosphate transport
(GO:0010966)
Regulation of phosphorus metabolic process
(GO:0051174)
Response to bile acid
(GO:1903412)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transport vesicle
(GO:0030133)
Vitamin d3 metabolic process
(GO:0070640)

Other Information

Proteins

Fibroblast growth factor receptor 4
A0A8L2QQB7_RAT

Genular Protein ID: 3926435437

Symbol: FGFR4_RAT

Name: Fibroblast growth factor receptor 4

UniProtKB Accession Codes:

Q498D6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17623664

Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

PubMed ID: 17623664

DOI: 10.1074/jbc.m704165200

Sequence Information:

Length: 800
Mass: 88708
Checksum: 4D3CF9C152C9A4EE
Sequence:

MWLLLALLSI FQETPAFSLE ASEEMEQEPC PAPISEQQEQ VLTVALGQPV RLCCGRTERG 
RHWYKEGSRL ASAGRVRGWR GRLEIASFLP EDAGRYLCLA RGSMTVVHNL TLIMDDSLPS 
INNEDPKTLS SSSSGHSYLQ QAPYWTHPQR MEKKLHAVPA GNTVKFRCPA AGNPMPTIHW 
LKNGQAFHGE NRIGGIRLRH QHWSLVMESV VPSDRGTYTC LVENSLGSIR YSYLLDVLER 
SPHRPILQAG LPANTTAVVG SNVELLCKVY SDAQPHIQWL KHIVINGSSF GADGFPYVQV 
LKTTDINSSE VEVLYLRNVS AEDAGEYTCL AGNSIGLSYQ SAWLTVLPAE EEDLAWTTAT 
SEARYTDIIL YVSGSLALVL LLLLAGVYHR QAIHGHHSRQ PVTVQKLSRF PLARQFSLES 
RSSGKSSLSL VRGVRLSSSG PPLLTGLVSL DLPLDPLWEF PRDRLVLGKP LGEGCFGQVV 
RAEALGMDSS RPDQTSTVAV KMLKDNASDK DLADLISEME MMKLIGRHKN IINLLGVCTQ 
EGPLYVIVEY AAKGNLREFL RARRPPGPDL SPDGPRSSEG PLSFPALVSC AYQVARGMQY 
LESRKCIHRD LAARNVLVTE DDVMKIADFG LARGVHHIDY YKKTSNGRLP VKWMAPEALF 
DRVYTHQSDV WSFGILLWEI FTLGGSPYPG IPVEELFSLL REGHRMERPP NCPSELYGLM 
RECWHAAPSQ RPTFKQLVEA LDKVLLAVSE EYLDLRLTFG PYSPNNGDAS STCSSSDSVF 
SHDPLPLEPS PFPFPEAQTT

Genular Protein ID: 257026215

Symbol: A0A8L2QQB7_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8L2QQB7

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 801
Mass: 88837
Checksum: 99466927BAF4AA34
Sequence:

MWLLLALLSI FQETPAFSLE ASEEMEQEPC PAPISEQQEQ VLTVALGQPV RLCCGRTERG 
RHWYKEGSRL ASAGRVRGWR GRLEIASFLP EDAGRYLCLA RGSMTVVHNL TLIMDDSLPS 
INNEDPKTLS SSSSGHSYLQ QAPYWTHPQR MEKKLHAVPA GNTVKFRCPA AGNPMPTIHW 
LKNGQAFHGE NRIGGIRLRH QHWSLVMESV VPSDRGTYTC LVENSLGSIR YSYLLDVLER 
SPHRPILQAG LPANTTAVVG SNVELLCKVY SDAQPHIQWL KHIVINGSSF GADGFPYVQV 
LKTTDINSSE VEVLYLRNVS AEDAGEYTCL AGNSIGLSYQ SAWLTVLPEA EEEDLAWTTA 
TSEARYTDII LYVSGSLALV LLLLLAGVYH RQAIHGHHSR QPVTVQKLSR FPLARQFSLE 
SRSSGKSSLS LVRGVRLSSS GPPLLTGLVS LDLPLDPLWE FPRDRLVLGK PLGEGCFGQV 
VRAEALGMDS SRPDQTSTVA VKMLKDNASD KDLADLISEM EMMKLIGRHK NIINLLGVCT 
QEGPLYVIVE YAAKGNLREF LRARRPPGPD LSPDGPRSSE GPLSFPALVS CAYQVARGMQ 
YLESRKCIHR DLAARNVLVT EDDVMKIADF GLARGVHHID YYKKTSNGRL PVKWMAPEAL 
FDRVYTHQSD VWSFGILLWE IFTLGGSPYP GIPVEELFSL LREGHRMERP PNCPSELYGL 
MRECWHAAPS QRPTFKQLVE ALDKVLLAVS EEYLDLRLTF GPYSPNNGDA SSTCSSSDSV 
FSHDPLPLEP SPFPFPEAQT T

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.