Details for: Hsd11b1

Gene ID: 25116

Symbol: Hsd11b1

Description: hydroxysteroid 11-beta dehydrogenase 1

Associated with

Other Information

Genular Protein ID: 12433392

Symbol: DHI1_RAT

Name: 7-oxosteroid reductase

UniProtKB Accession Codes:

P16232 O09170 Q6LDH6

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 2 Bgee 1 BindingDB 1 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 DrugCentral 1 EC 2 EMBL 5 ExpressionAtlas 1 GO 18 Gene3D 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 2 RefSeq 2 Rhea 30 SABIO-RK 1 SMR 1 SUPFAM 1 UniProtKB 2 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 2808402

Title: Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.

PubMed ID: 2808402

DOI: 10.1016/s0021-9258(19)47248-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1508221

Title: Differential promoter usage by the rat 11 beta-hydroxysteroid dehydrogenase gene.

PubMed ID: 1508221

DOI: 10.1210/mend.6.7.1508221

PubMed ID: 10906322

Title: C/EBP regulates hepatic transcription of 11beta-hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways.

PubMed ID: 10906322

DOI: 10.1074/jbc.m001286200

PubMed ID: 12460758

Title: Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.

PubMed ID: 12460758

DOI: 10.1016/s1046-5928(02)00547-8

PubMed ID: 1733955

Title: Tissue-specific expression of an 11 beta-hydroxysteroid dehydrogenase with a truncated N-terminal domain. A potential mechanism for differential intracellular localization within mineralocorticoid target cells.

PubMed ID: 1733955

DOI: 10.1016/s0021-9258(18)45918-2

PubMed ID: 3460996

Title: The syndrome of apparent mineralocorticoid excess: its association with 11 beta-dehydrogenase and 5 beta-reductase deficiency and some consequences for corticosteroid metabolism.

PubMed ID: 3460996

DOI: 10.1210/jcem-63-3-550

PubMed ID: 2387261

Title: 11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex.

PubMed ID: 2387261

DOI: 10.1210/endo-127-3-1450

PubMed ID: 8613810

Title: 11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity.

PubMed ID: 8613810

DOI: 10.1523/jneurosci.16-01-00065.1996

PubMed ID: 14973125

Title: Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

PubMed ID: 14973125

DOI: 10.1074/jbc.m313615200

PubMed ID: 21453287

Title: Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11beta-hydroxysteroid dehydrogenase 1.

PubMed ID: 21453287

DOI: 10.1042/bj20110022

PubMed ID: 1417845

Title: Tyr-179 and Lys-183 are essential for enzymatic activity of 11 beta-hydroxysteroid dehydrogenase.

PubMed ID: 1417845

DOI: 10.1016/0006-291x(92)92373-6

Sequence Information:

  • Length: 288
  • Mass: 31883
  • Checksum: AC445C0D92004808
  • Sequence:
    • MKKYLLPVLV LCLGYYYSTN EEFRPEMLQG KKVIVTGASK GIGREMAYHL SKMGAHVVLT 
ARSEEGLQKV VSRCLELGAA SAHYIAGTME DMAFAERFVV EAGKLLGGLD MLILNHITQT 
TMSLFHDDIH SVRRSMEVNF LSYVVLSTAA LPMLKQSNGS IAIISSMAGK MTQPLIASYS 
ASKFALDGFF STIRKEHLMT KVNVSITLCV LGFIDTETAL KETSGIILSQ AAPKEECALE 
IIKGTVLRKD EVYYDKSSWT PLLLGNPGRR IMEFLSLRSY NRDLFVSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.