Details for: Scnn1a

Gene ID: 25122

Symbol: Scnn1a

Ensembl ID: ENSRNOG00000019368

Description: sodium channel epithelial 1 subunit alpha

Associated with

Other Information

Genular Protein ID: 1614902055

Symbol: SCNNA_RAT

Name: Amiloride-sensitive sodium channel subunit alpha

UniProtKB Accession Codes:

P37089 Q64593 Q9QUI4

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 CTD 1 ComplexPortal 1 DIP 1 EMBL 6 GO 29 Gene3D 2 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8382172

Title: Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins.

PubMed ID: 8382172

DOI: 10.1016/0014-5793(93)81336-x

PubMed ID: 8381523

Title: Epithelial sodium channel related to proteins involved in neurodegeneration.

PubMed ID: 8381523

DOI: 10.1038/361467a0

PubMed ID: 9039092

Title: Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension.

PubMed ID: 9039092

DOI: 10.1161/01.hyp.29.1.131

PubMed ID: 10226074

Title: Structure and hormone responsiveness of the gene encoding the alpha-subunit of the rat amiloride-sensitive epithelial sodium channel.

PubMed ID: 10226074

DOI: 10.1165/ajrcmb.20.5.3382

PubMed ID: 7929098

Title: Membrane topology of the amiloride-sensitive epithelial sodium channel.

PubMed ID: 7929098

DOI: 10.1016/s0021-9258(19)51094-8

PubMed ID: 8175716

Title: Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel.

PubMed ID: 8175716

DOI: 10.1016/s0021-9258(18)99972-2

PubMed ID: 7744818

Title: Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function.

PubMed ID: 7744818

DOI: 10.1074/jbc.270.20.11735

PubMed ID: 9118951

Title: A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.

PubMed ID: 9118951

DOI: 10.1093/emboj/16.5.899

PubMed ID: 9351815

Title: Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

PubMed ID: 9351815

DOI: 10.1093/emboj/16.21.6325

PubMed ID: 11352848

Title: Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney.

PubMed ID: 11352848

DOI: 10.1152/ajprenal.2001.280.6.f1093

PubMed ID: 11323714

Title: Solution structure of a Nedd4 WW domain-ENaC peptide complex.

PubMed ID: 11323714

DOI: 10.1038/87562

PubMed ID: 11773057

Title: Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells.

PubMed ID: 11773057

DOI: 10.1074/jbc.m110904200

PubMed ID: 14556380

Title: Identification of new partners of the epithelial sodium channel alpha subunit.

PubMed ID: 14556380

DOI: 10.1016/s1631-0691(03)00154-9

PubMed ID: 29453757

Title: Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa.

PubMed ID: 29453757

DOI: 10.1007/s10735-018-9759-2

Sequence Information:

  • Length: 698
  • Mass: 78888
  • Checksum: B0CF7C15C3CE9763
  • Sequence:
    • MLDHTRAPEL NIDLDLHASN SPKGSMKGNQ FKEQDPCPPQ PMQGLGKGDK REEQGLGPEP 
SAPRQPTEEE EALIEFHRSY RELFQFFCNN TTIHGAIRLV CSKHNRMKTA FWAVLWLCTF 
GMMYWQFALL FEEYLSYPVS LNINLNSDKL VFPAVTVCTL NPYRYTEIKE ELEELDRITE 
QTLFDLYKYN SSYTRQAGAR RRSSRDLLGA FPHPLQRLRT PPPPYSGRTA RSGSSSVRDN 
NPQVDRKDWK IGFQLCNQNK SDCFYQTYSS GVDAVREWYR FHYINILSRL SDTSPALEEE 
ALGNFIFTCR FNQAPCNQAN YSKFHHPMYG NCYTFNDKNN SNLWMSSMPG VNNGLSLTLR 
TEQNDFIPLL STVTGARVMV HGQDEPAFMD DGGFNLRPGV ETSISMRKEA LDSLGGNYGD 
CTENGSDVPV KNLYPSKYTQ QVCIHSCFQE NMIKKCGCAY IFYPKPKGVE FCDYRKQSSW 
GYCYYKLQGA FSLDSLGCFS KCRKPCSVIN YKLSAGYSRW PSVKSQDWIF EMLSLQNNYT 
INNKRNGVAK LNIFFKELNY KTNSESPSVT MVSLLSNLGS QWSLWFGSSV LSVVEMAELI 
FDLLVITLLM LLRRFRSRYW SPGRGARGAR EVASTPASSF PSRFCPHPTS PPPSLPQQGM 
TPPLALTAPP PAYATLGPSA PPLDSAAPDC SACALAAL

Genular Protein ID: 149488423

Symbol: B8QP47_RAT

Name: N/A

UniProtKB Accession Codes:

B8QP47

Database IDs:

ARBA 25 CTD 1 EMBL 4 GO 2 Gene3D 2 HOGENOM 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 Proteomes 1 RGD 2 RefSeq 1 SAM 2 TreeFam 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 699
  • Mass: 79019
  • Checksum: CCE2048C9392260A
  • Sequence:
    • MMLDHTRAPE LNIDLDLHAS NSPKGSMKGN QFKEQDPCPP QPMQGLGKGD KREEQGLGPE 
PSAPRQPTEE EEALIEFHRS YRELFQFFCN NTTIHGAIRL VCSKHNRMKT AFWAVLWLCT 
FGMMYWQFAL LFEEYLSYPV SLNINLNSDK LVFPAVTVCT LNPYRYTEIK EELEELDRIT 
EQTLFDLYKY NSSYTRQAGA RRRSSRDLLG AFPHPLQRLR TPPPPYSGRT ARSGSSSVRD 
NNPQVDRKDW KIGFQLCNQN KSDCFYQTYS SGVDAVREWY RFHYINILSR LSDTSPALEE 
EALGNFIFTC RFNQAPCNQA NYSKFHHPMY GNCYTFNDKN NSNLWMSSMP GVNNGLSLTL 
RTEQNDFIPL LSTVTGARVM VHGQDEPAFM DDGGFNLRPG VETSISMRKE ALDSLGGNYG 
DCTENGSDVP VKNLYPSKYT QQVCIHSCFQ ENMIKKCGCA YIFYPKPKGV EFCDYRKQSS 
WGYCYYKLQG AFSLDSLGCF SKCRKPCSVI NYKLSAGYSR WPSVKSQDWI FEMLSLQNNY 
TINNKRNGVA KLNIFFKELN YKTNSESPSV TMVSLLSNLG SQWSLWFGSS VLSVVEMAEL 
IFDLLVITLL MLLRRFRSRY WSPGRGARGA REVASTPASS FPSRFCPHPT SPPPSLPQQG 
MTPPLALTAP PPAYATLGPS APPLDSAAPD CSACALAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.