Genular: Defining Cellular Identity and Function

Details for: Umod

Gene ID: 25128

Symbol: Umod

Ensembl ID: ENSRNOG00000015557

Description: uromodulin

Associated with

Asparagine n-linked glycosylation
(R-RNO-446203)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Antibacterial innate immune response
(GO:0140367)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Autophagy
(GO:0006914)
Basolateral plasma membrane
(GO:0016323)
Calcium ion binding
(GO:0005509)
Calcium ion homeostasis
(GO:0055074)
Cell surface
(GO:0009986)
Cellular response to unfolded protein
(GO:0034620)
Chaperone-mediated protein folding
(GO:0061077)
Chemical homeostasis
(GO:0048878)
Chloride ion homeostasis
(GO:0055064)
Ciliary membrane
(GO:0060170)
Cilium
(GO:0005929)
Citric acid secretion
(GO:0046720)
Collecting duct development
(GO:0072044)
Connective tissue replacement
(GO:0097709)
Defense response to gram-negative bacterium
(GO:0050829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum organization
(GO:0007029)
Erad pathway
(GO:0036503)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gene expression
(GO:0010467)
Glomerular filtration
(GO:0003094)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Igg binding
(GO:0019864)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular chloride ion homeostasis
(GO:0030644)
Intracellular phosphate ion homeostasis
(GO:0030643)
Intracellular sodium ion homeostasis
(GO:0006883)
Juxtaglomerular apparatus development
(GO:0072051)
Kidney development
(GO:0001822)
Leukocyte cell-cell adhesion
(GO:0007159)
Lipid metabolic process
(GO:0006629)
Loop of henle development
(GO:0072070)
Membrane
(GO:0016020)
Metanephric ascending thin limb development
(GO:0072218)
Metanephric distal convoluted tubule development
(GO:0072221)
Metanephric thick ascending limb development
(GO:0072233)
Micturition
(GO:0060073)
Monoatomic ion homeostasis
(GO:0050801)
Multicellular organismal-level homeostasis
(GO:0048871)
Multicellular organismal-level water homeostasis
(GO:0050891)
Multicellular organismal response to stress
(GO:0033555)
Neutrophil migration
(GO:1990266)
Organ or tissue specific immune response
(GO:0002251)
Phosphate ion homeostasis
(GO:0055062)
Plasma membrane
(GO:0005886)
Potassium ion homeostasis
(GO:0055075)
Protein binding
(GO:0005515)
Protein localization to vacuole
(GO:0072665)
Protein transport into plasma membrane raft
(GO:0044861)
Regulation of blood pressure
(GO:0008217)
Regulation of protein transport
(GO:0051223)
Regulation of urine volume
(GO:0035809)
Renal sodium ion absorption
(GO:0070294)
Renal urate salt excretion
(GO:0097744)
Renal water homeostasis
(GO:0003091)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to lipopolysaccharide
(GO:0032496)
Response to organic substance
(GO:0010033)
Response to unfolded protein
(GO:0006986)
Response to water deprivation
(GO:0009414)
Response to xenobiotic stimulus
(GO:0009410)
Rna splicing
(GO:0008380)
Side of membrane
(GO:0098552)
Sodium ion homeostasis
(GO:0055078)
Spindle pole
(GO:0000922)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Urate transport
(GO:0015747)
Urea transmembrane transport
(GO:0071918)

Other Information

Proteins

Uromodulin

Genular Protein ID: 404289040

Symbol: UROM_RAT

Name: Uromodulin

UniProtKB Accession Codes:

P27590 Q642D6

Database IDs:

Citations:

PubMed ID: 1531535

Title: GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney.

PubMed ID: 1531535

DOI: 10.1073/pnas.89.4.1189

PubMed ID: 7531049

Title: Bovine and rodent Tamm-Horsfall protein (THP) genes: cloning, structural analysis, and promoter identification.

PubMed ID: 7531049

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 379435

Title: Tamm-Horsfall glycoprotein: ultrastructural immunoperoxidase localization in rat kidney.

PubMed ID: 379435

Sequence Information:

Length: 644
Mass: 71062
Checksum: D26DB419C669826A
Sequence:

MGQLLSLTWL LLVMVVTPWF TVAGANDSPE ARRCSECHDN ATCVLDGVVT TCSCQAGFTG 
DGLVCEDIDE CATPWTHNCS NSICMNTLGS YECSCQDGFR LTPGLGCIDV NECTEQGLSN 
CHSLATCVNT EGSYSCVCPK GYRGDGWYCE CSPGFCEPGL DCLPQGPSGK LVCQDPCNVY 
ETLTEYWRST DYGAGYSCDS DMHGWYRFTG QGGVRMAETC VPVLRCNTAA PMWLNGSHPS 
SREGIVSRTA CAHWSDHCCL WSTEIQVKAC PGGFYVYNLT EPPECNLAYC TDPSSVEGTC 
EECGVDEDCV SDNGRWRCQC KQDFNVTDVS LLEHRLECEA NEIKISLSKC QLQSLGFMKV 
FMYLNDRQCS GFSERGERDW MSIVTPARDG PCGTVLRRNE THATYSNTLY LASEIIIRDI 
NIRINFECSY PLDMKVSLKT SLQPMVSALN ISLGGTGKFT VQMALFQNPT YTQPYQGPSV 
MLSTEAFLYV GTMLDGGDLS RFVLLMTNCY ATPSSNSTDP VKYFIIQDRC PHTEDTTIQV 
TENGESSQAR FSIQMFRFAG NSDLVYLHCE VYLCDTMSEQ CKPTCSGTRY RSGNFIDQTR 
VLNLGPITRQ GVQASVSKAA SSNLGFLSIW LLLFLSATLT LMVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Umod

Associated with

Other Information

GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. PubMed ID: 1531535

Bovine and rodent Tamm-Horsfall protein (THP) genes: cloning, structural analysis, and promoter identification. PubMed ID: 7531049

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tamm-Horsfall glycoprotein: ultrastructural immunoperoxidase localization in rat kidney. PubMed ID: 379435

Database document:

PubMed ID: 1531535

PubMed ID: 7531049

PubMed ID: 15489334

PubMed ID: 379435