Gnmt | ENSRNOG00000016349 | NCBI 25134

Details for: Gnmt

Gene ID: 25134

Symbol: Gnmt

Ensembl ID: ENSRNOG00000016349

Description: glycine N-methyltransferase

Associated with

Glyoxylate metabolism and glycine degradation
(R-RNO-389661)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Cytosol
(GO:0005829)
Folic acid binding
(GO:0005542)
Glycine binding
(GO:0016594)
Glycine metabolic process
(GO:0006544)
Glycine n-methyltransferase activity
(GO:0017174)
Glycogen metabolic process
(GO:0005977)
Identical protein binding
(GO:0042802)
Methionine metabolic process
(GO:0006555)
Methylation
(GO:0032259)
Methyltransferase complex
(GO:0034708)
One-carbon metabolic process
(GO:0006730)
Protein homotetramerization
(GO:0051289)
Regulation of gluconeogenesis
(GO:0006111)
S-adenosyl-l-methionine binding
(GO:1904047)
S-adenosylhomocysteine metabolic process
(GO:0046498)
S-adenosylmethionine-dependent methyltransferase activity
(GO:0008757)
S-adenosylmethionine metabolic process
(GO:0046500)
Sarcosine metabolic process
(GO:1901052)
Selenol se-methyltransferase activity
(GO:0098603)

Other Information

Proteins

Glycine N-methyltransferase

Genular Protein ID: 395261265

Symbol: GNMT_RAT

Name: Glycine N-methyltransferase

UniProtKB Accession Codes:

P13255

Database IDs:

Citations:

PubMed ID: 2822402

Title: Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA.

PubMed ID: 2822402

DOI: 10.1111/j.1432-1033.1987.tb13398.x

PubMed ID: 6587377

Title: Glycine N-methyltransferase is a folate binding protein of rat liver cytosol.

PubMed ID: 6587377

DOI: 10.1073/pnas.81.12.3631

PubMed ID: 3838667

Title: Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism.

PubMed ID: 3838667

DOI: 10.1016/s0006-291x(85)80006-1

PubMed ID: 8810903

Title: Crystal structure of glycine N-methyltransferase from rat liver.

PubMed ID: 8810903

DOI: 10.1021/bi961068n

PubMed ID: 9655336

Title: Crystal structure of apo-glycine N-methyltransferase (GNMT).

PubMed ID: 9655336

DOI: 10.1002/pro.5560070608

PubMed ID: 10756111

Title: Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.

PubMed ID: 10756111

DOI: 10.1006/jmbi.2000.3637

PubMed ID: 12859184

Title: Catalytic mechanism of glycine N-methyltransferase.

PubMed ID: 12859184

DOI: 10.1021/bi034245a

PubMed ID: 17158459

Title: 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.

PubMed ID: 17158459

DOI: 10.1074/jbc.m610384200

PubMed ID: 22037183

Title: Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.

PubMed ID: 22037183

DOI: 10.1016/j.bbapap.2011.10.008

Sequence Information:

Length: 293
Mass: 32549
Checksum: 4E98C7512F0228A5
Sequence:

MVDSVYRTRS LGVAAEGIPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCHR 
VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRKEPAFDK WVIEEANWLT 
LDKDVPAGDG FDAVICLGNS FAHLPDSKGD QSEHRLALKN IASMVRPGGL LVIDHRNYDY 
ILSTGCAPPG KNIYYKSDLT KDITTSVLTV NNKAHMVTLD YTVQVPGAGR DGAPGFSKFR 
LSYYPHCLAS FTELVQEAFG GRCQHSVLGD FKPYRPGQAY VPCYFIHVLK KTG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gnmt

Associated with

Other Information

Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA. PubMed ID: 2822402

Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. PubMed ID: 6587377

Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism. PubMed ID: 3838667

Crystal structure of glycine N-methyltransferase from rat liver. PubMed ID: 8810903

Crystal structure of apo-glycine N-methyltransferase (GNMT). PubMed ID: 9655336

Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. PubMed ID: 10756111

Catalytic mechanism of glycine N-methyltransferase. PubMed ID: 12859184

5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. PubMed ID: 17158459

Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. PubMed ID: 22037183