Genular: Defining Cellular Identity and Function

Details for: Slc2a4

Gene ID: 25139

Symbol: Slc2a4

Ensembl ID: ENSRNOG00000017226

Description: solute carrier family 2 member 4

Associated with

Cellular hexose transport
(R-RNO-189200)
Slc-mediated transmembrane transport
(R-RNO-425407)
Transport of small molecules
(R-RNO-382551)
Amylopectin biosynthetic process
(GO:0010021)
Brown fat cell differentiation
(GO:0050873)
Cell surface
(GO:0009986)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to osmotic stress
(GO:0071470)
Cellular response to tumor necrosis factor
(GO:0071356)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle
(GO:0030136)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
D-glucose transmembrane transporter activity
(GO:0055056)
Dehydroascorbic acid transport
(GO:0070837)
Endomembrane system
(GO:0012505)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Glucose homeostasis
(GO:0042593)
Glucose import
(GO:0046323)
Glucose import in response to insulin stimulus
(GO:0044381)
Glucose transmembrane transport
(GO:1904659)
Glucose transmembrane transporter activity
(GO:0005355)
Glucose uniporter activity
(GO:0015304)
Insulin-responsive compartment
(GO:0032593)
Learning or memory
(GO:0007611)
Long-term memory
(GO:0007616)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Multivesicular body
(GO:0005771)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of brain-derived neurotrophic factor receptor signaling pathway
(GO:0031550)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Regulation of synaptic vesicle budding from presynaptic endocytic zone membrane
(GO:0098694)
Response to ethanol
(GO:0045471)
Sarcolemma
(GO:0042383)
Sarcoplasmic reticulum
(GO:0016529)
Short-term memory
(GO:0007614)
T-tubule
(GO:0030315)
Trans-golgi network
(GO:0005802)
Trans-golgi network transport vesicle
(GO:0030140)
Vesicle
(GO:0031982)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

GLUT4_RAT

Genular Protein ID: 1908957278

Symbol: GLUT4_RAT

Name: N/A

UniProtKB Accession Codes:

P19357 P97900

Database IDs:

Citations:

PubMed ID: 2649253

Title: Identification of a novel gene encoding an insulin-responsive glucose transporter protein.

PubMed ID: 2649253

DOI: 10.1016/0092-8674(89)90968-9

PubMed ID: 2645527

Title: Molecular cloning and characterization of an insulin-regulatable glucose transporter.

PubMed ID: 2645527

DOI: 10.1038/338083a0

PubMed ID: 2649883

Title: A glucose transport protein expressed predominately in insulin-responsive tissues.

PubMed ID: 2649883

DOI: 10.1073/pnas.86.8.2535

PubMed ID: 9059504

Title: Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae: comparison with Glut1 glucose transporter.

PubMed ID: 9059504

DOI: 10.1016/s0005-2736(96)00217-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7545962

Title: Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene.

PubMed ID: 7545962

DOI: 10.1016/s0021-9258(18)46957-8

PubMed ID: 7720644

Title: Characterization of 5'-heterogeneity of the rat GLUT4/muscle-adipose glucose transporter gene product.

PubMed ID: 7720644

DOI: 10.1210/endo.136.5.7720644

PubMed ID: 2211693

Title: Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

PubMed ID: 2211693

DOI: 10.1016/s0021-9258(17)44734-x

PubMed ID: 1651337

Title: Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type.

PubMed ID: 1651337

DOI: 10.1083/jcb.114.4.689

PubMed ID: 16396496

Title: Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).

PubMed ID: 16396496

DOI: 10.1021/pr0502626

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 26240143

Title: Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.

PubMed ID: 26240143

DOI: 10.1074/jbc.m115.657361

Sequence Information:

Length: 509
Mass: 54896
Checksum: DA50321E99E4CA90
Sequence:

MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNATW 
LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLANNVLAV 
LGGALMGLAN AAASYEILIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI 
VIGILVAQVL GLESMLGTAT LWPLLLAITV LPALLQLLLL PFCPESPRYL YIIRNLEGPA 
RKSLKRLTGW ADVSDALAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL 
SGINAVFYYS TSIFELAGVE QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM 
CGCAILMTVA LLLLERVPSM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM 
AVAGFSNWTC NFIVGMGFQY VADAMGPYVF LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS 
ATFRRTPSLL EQEVKPSTEL EYLGPDEND

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc2a4

Associated with

Other Information

Identification of a novel gene encoding an insulin-responsive glucose transporter protein. PubMed ID: 2649253

Molecular cloning and characterization of an insulin-regulatable glucose transporter. PubMed ID: 2645527

A glucose transport protein expressed predominately in insulin-responsive tissues. PubMed ID: 2649883

Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae: comparison with Glut1 glucose transporter. PubMed ID: 9059504

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. PubMed ID: 7545962

Characterization of 5'-heterogeneity of the rat GLUT4/muscle-adipose glucose transporter gene product. PubMed ID: 7720644

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. PubMed ID: 2211693

Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type. PubMed ID: 1651337

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). PubMed ID: 16396496

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. PubMed ID: 26240143