Details for: Cyp17a1

Gene ID: 25146

Symbol: Cyp17a1

Ensembl ID: ENSRNOG00000020035

Description: cytochrome P450, family 17, subfamily a, polypeptide 1

Associated with

Other Information

Genular Protein ID: 1026496528

Symbol: CP17A_RAT

Name: Steroid 17-alpha-hydroxylase/17,20 lyase

UniProtKB Accession Codes:

P11715 Q68FY2 Q6LAE5

Database IDs:

AGR 1 AlphaFoldDB 1 BindingDB 1 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 DrugCentral 1 EC 5 EMBL 8 Ensembl 1 GO 43 Gene3D 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 3 Rhea 40 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2786990

Title: Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions.

PubMed ID: 2786990

DOI: 10.1210/mend-3-6-968

PubMed ID: 3264499

Title: Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration.

PubMed ID: 3264499

DOI: 10.1016/s0006-291x(88)80307-3

PubMed ID: 7702752

Title: Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities.

PubMed ID: 7702752

DOI: 10.1089/dna.1994.13.1087

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1627653

Title: Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete nucleotide sequence of the porcine gene and 5' upstream sequence of the rat gene.

PubMed ID: 1627653

DOI: 10.1016/0167-4781(92)90039-3

PubMed ID: 3260774

Title: Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA.

PubMed ID: 3260774

DOI: 10.1016/0006-291x(88)90663-8

PubMed ID: 2554289

Title: cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

PubMed ID: 2554289

DOI: 10.1073/pnas.86.20.7775

PubMed ID: 3436956

Title: Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats.

PubMed ID: 3436956

DOI: 10.1093/oxfordjournals.jbchem.a122124

Sequence Information:

  • Length: 507
  • Mass: 57250
  • Checksum: A535600F7E6A399B
  • Sequence:
    • MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH VNFFKLQEKY 
GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV TQSLLSDQGK GVAFADAGSS 
WHLHRKLVFS TFSLFKDGQK LEKLICQEAK SLCDMMLAHD KESIDLSTPI FMSVTNIICA 
ICFNISYEKN DPKLTAIKTF TEGIVDATGD RNLVDIFPWL TIFPNKGLEV IKGYAKVRNE 
VLTGIFEKCR EKFDSQSISS LTDILIQAKM NSDNNNSCEG RDPDVFSDRH ILATVGDIFG 
AGIETTTTVL KWILAFLVHN PEVKKKIQKE IDQYVGFSRT PTFNDRSHLL MLEATIREVL 
RIRPVAPMLI PHKANVDSSI GEFTVPKDTH VVVNLWALHH DENEWDQPDQ FMPERFLDPT 
GSHLITPTQS YLPFGAGPRS CIGEALARQE LFVFTALLLQ RFDLDVSDDK QLPRLEGDPK 
VVFLIDPFKV KITVRQAWMD AQAEVST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.