Genular: Defining Cellular Identity and Function

Details for: Cyp17a1

Gene ID: 25146

Symbol: Cyp17a1

Ensembl ID: ENSRNOG00000020035

Description: cytochrome P450, family 17, subfamily a, polypeptide 1

Associated with

Androgen biosynthesis
(R-RNO-193048)
Glucocorticoid biosynthesis
(R-RNO-194002)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of steroid hormones
(R-RNO-196071)
Metabolism of steroids
(R-RNO-8957322)
17-alpha-hydroxyprogesterone aldolase activity
(GO:0047442)
Adrenal gland development
(GO:0030325)
Androgen biosynthetic process
(GO:0006702)
Axon
(GO:0030424)
Biphenyl metabolic process
(GO:0018879)
Cell projection
(GO:0042995)
Cellular response to antibiotic
(GO:0071236)
Cellular response to gonadotropin stimulus
(GO:0071371)
Cellular response to lipopolysaccharide
(GO:0071222)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Glucocorticoid biosynthetic process
(GO:0006704)
Heme binding
(GO:0020037)
Hippocampus development
(GO:0021766)
Hormone biosynthetic process
(GO:0042446)
Iron ion binding
(GO:0005506)
Leydig cell differentiation
(GO:0033327)
Male gonad development
(GO:0008584)
Monooxygenase activity
(GO:0004497)
Neuronal cell body
(GO:0043025)
Organic acid metabolic process
(GO:0006082)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Phenol-containing compound metabolic process
(GO:0018958)
Phthalate metabolic process
(GO:0018963)
Positive regulation of steroid hormone biosynthetic process
(GO:0090031)
Progesterone metabolic process
(GO:0042448)
Response to acetate
(GO:0010034)
Response to camp
(GO:0051591)
Response to cytokine
(GO:0034097)
Response to fungicide
(GO:0060992)
Response to gonadotropin
(GO:0034698)
Response to herbicide
(GO:0009635)
Response to insecticide
(GO:0017085)
Response to ionizing radiation
(GO:0010212)
Response to methylmercury
(GO:0051597)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to retinoic acid
(GO:0032526)
Response to steroid hormone
(GO:0048545)
Response to toxic substance
(GO:0009636)
Response to xenobiotic stimulus
(GO:0009410)
Steroid 17-alpha-monooxygenase activity
(GO:0004508)
Steroid biosynthetic process
(GO:0006694)
Steroid metabolic process
(GO:0008202)

Other Information

Proteins

Steroid 17-alpha-hydroxylase/17,20 lyase

Genular Protein ID: 1026496528

Symbol: CP17A_RAT

Name: Steroid 17-alpha-hydroxylase/17,20 lyase

UniProtKB Accession Codes:

P11715 Q68FY2 Q6LAE5

Database IDs:

Citations:

PubMed ID: 2786990

Title: Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions.

PubMed ID: 2786990

DOI: 10.1210/mend-3-6-968

PubMed ID: 3264499

Title: Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration.

PubMed ID: 3264499

DOI: 10.1016/s0006-291x(88)80307-3

PubMed ID: 7702752

Title: Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities.

PubMed ID: 7702752

DOI: 10.1089/dna.1994.13.1087

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1627653

Title: Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete nucleotide sequence of the porcine gene and 5' upstream sequence of the rat gene.

PubMed ID: 1627653

DOI: 10.1016/0167-4781(92)90039-3

PubMed ID: 3260774

Title: Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA.

PubMed ID: 3260774

DOI: 10.1016/0006-291x(88)90663-8

PubMed ID: 2554289

Title: cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

PubMed ID: 2554289

DOI: 10.1073/pnas.86.20.7775

PubMed ID: 3436956

Title: Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats.

PubMed ID: 3436956

DOI: 10.1093/oxfordjournals.jbchem.a122124

Sequence Information:

Length: 507
Mass: 57250
Checksum: A535600F7E6A399B
Sequence:

MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH VNFFKLQEKY 
GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV TQSLLSDQGK GVAFADAGSS 
WHLHRKLVFS TFSLFKDGQK LEKLICQEAK SLCDMMLAHD KESIDLSTPI FMSVTNIICA 
ICFNISYEKN DPKLTAIKTF TEGIVDATGD RNLVDIFPWL TIFPNKGLEV IKGYAKVRNE 
VLTGIFEKCR EKFDSQSISS LTDILIQAKM NSDNNNSCEG RDPDVFSDRH ILATVGDIFG 
AGIETTTTVL KWILAFLVHN PEVKKKIQKE IDQYVGFSRT PTFNDRSHLL MLEATIREVL 
RIRPVAPMLI PHKANVDSSI GEFTVPKDTH VVVNLWALHH DENEWDQPDQ FMPERFLDPT 
GSHLITPTQS YLPFGAGPRS CIGEALARQE LFVFTALLLQ RFDLDVSDDK QLPRLEGDPK 
VVFLIDPFKV KITVRQAWMD AQAEVST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp17a1

Associated with

Other Information

Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions. PubMed ID: 2786990

Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration. PubMed ID: 3264499

Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities. PubMed ID: 7702752

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete nucleotide sequence of the porcine gene and 5' upstream sequence of the rat gene. PubMed ID: 1627653

Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA. PubMed ID: 3260774

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. PubMed ID: 2554289

Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats. PubMed ID: 3436956