Details for: Syk

Gene ID: 25155

Symbol: Syk

Ensembl ID: ENSRNOG00000012160

Description: spleen associated tyrosine kinase

Associated with

  • Adaptive immune response
    (GO:0002250)
  • Angiogenesis
    (GO:0001525)
  • Atp binding
    (GO:0005524)
  • B cell differentiation
    (GO:0030183)
  • B cell receptor signaling pathway
    (GO:0050853)
  • Beta selection
    (GO:0043366)
  • Blood vessel morphogenesis
    (GO:0048514)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell activation
    (GO:0001775)
  • Cell differentiation
    (GO:0030154)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to lipid
    (GO:0071396)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular response to molecule of fungal origin
    (GO:0071226)
  • Collagen-activated tyrosine kinase receptor signaling pathway
    (GO:0038063)
  • Defense response to bacterium
    (GO:0042742)
  • Enzyme-linked receptor protein signaling pathway
    (GO:0007167)
  • Establishment of localization in cell
    (GO:0051649)
  • Gamma-delta t cell differentiation
    (GO:0042492)
  • Immune system process
    (GO:0002376)
  • Innate immune response
    (GO:0045087)
  • Integrin-mediated signaling pathway
    (GO:0007229)
  • Integrin binding
    (GO:0005178)
  • Interleukin-3-mediated signaling pathway
    (GO:0038156)
  • Interleukin-15 receptor binding
    (GO:0016170)
  • Intracellular signal transduction
    (GO:0035556)
  • Kinase activity
    (GO:0016301)
  • Leukocyte activation involved in immune response
    (GO:0002366)
  • Leukocyte cell-cell adhesion
    (GO:0007159)
  • Leukotriene biosynthetic process
    (GO:0019370)
  • Lymph vessel development
    (GO:0001945)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Mast cell degranulation
    (GO:0043303)
  • Neutrophil activation involved in immune response
    (GO:0002283)
  • Neutrophil chemotaxis
    (GO:0030593)
  • Non-membrane spanning protein tyrosine kinase activity
    (GO:0004715)
  • Phosphatase binding
    (GO:0019902)
  • Phospholipase binding
    (GO:0043274)
  • Phosphorylation
    (GO:0016310)
  • Phosphotyrosine residue binding
    (GO:0001784)
  • Positive regulation of alpha-beta t cell differentiation
    (GO:0046638)
  • Positive regulation of alpha-beta t cell proliferation
    (GO:0046641)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of bone resorption
    (GO:0045780)
  • Positive regulation of calcium-mediated signaling
    (GO:0050850)
  • Positive regulation of cell adhesion mediated by integrin
    (GO:0033630)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of gamma-delta t cell differentiation
    (GO:0045588)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of immune response
    (GO:0050778)
  • Positive regulation of interleukin-3 production
    (GO:0032752)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of killing of cells of another organism
    (GO:0051712)
  • Positive regulation of leukocyte activation
    (GO:0002696)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mast cell cytokine production
    (GO:0032765)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of receptor internalization
    (GO:0002092)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type i interferon production
    (GO:0032481)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Protein import into nucleus
    (GO:0006606)
  • Protein kinase activity
    (GO:0004672)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Receptor internalization
    (GO:0031623)
  • Regulation of arachidonic acid secretion
    (GO:0090237)
  • Regulation of erk1 and erk2 cascade
    (GO:0070372)
  • Regulation of immune response
    (GO:0050776)
  • Regulation of neutrophil degranulation
    (GO:0043313)
  • Regulation of phagocytosis
    (GO:0050764)
  • Regulation of platelet activation
    (GO:0010543)
  • Regulation of platelet aggregation
    (GO:0090330)
  • Regulation of superoxide anion generation
    (GO:0032928)
  • Regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010803)
  • Scaffold protein binding
    (GO:0097110)
  • Serotonin secretion
    (GO:0001820)
  • Serotonin secretion by platelet
    (GO:0002554)
  • Sh2 domain binding
    (GO:0042169)
  • Signaling receptor binding
    (GO:0005102)
  • Stimulatory c-type lectin receptor signaling pathway
    (GO:0002223)
  • Toll-like receptor binding
    (GO:0035325)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 2034178698

Symbol: KSYK_RAT

Name: Tyrosine-protein kinase SYK

UniProtKB Accession Codes:

Q64725

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 CDD 3 CTD 1 ChEBI 7 ChEMBL 1 EC 2 EMBL 2 GO 100 Gene3D 2 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 16 RefSeq 1 Rhea 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7759516

Title: Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing.

PubMed ID: 7759516

DOI: 10.1074/jbc.270.21.12659

PubMed ID: 8611520

Title: SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases.

PubMed ID: 8611520

DOI: 10.1021/bi9528614

PubMed ID: 12077122

Title: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.

PubMed ID: 12077122

DOI: 10.1074/jbc.m201362200

Sequence Information:

  • Length: 629
  • Mass: 71529
  • Checksum: 81169A643EC6A6FE
  • Sequence:
    • MAGNAVDNAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA 
HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPEGLVC LLKKPFNRPP GVQPKTGPFE 
DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT 
VLIGSKTNGK FLIRARDNNG SFALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV 
EHYSYKPDGL LRVLTVPCQK IGVQMGHPGS SNAHPVTWSP GGIISRIKSY SFPKPGHKKP 
PPPQGSRPES TVSFNPYEPT GGAWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD 
RKLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ 
LDNPYIVRMI GICEAESWML VMEMAAWGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE 
ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY 
FKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPPG CPREMYDLMF 
LCWTYDVENR PGFAAVELRL RNYYYDVVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.