Genular: Defining Cellular Identity and Function

Details for: Cdkn2a

Gene ID: 25163

Symbol: Cdkn2a

Ensembl ID: ENSRNOG00000059837

Description: cyclin-dependent kinase inhibitor 2A

Associated with

Amyloid fibril formation
(GO:1990000)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process
(GO:0006915)
Apoptotic process involved in mammary gland involution
(GO:0060057)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular senescence
(GO:0090398)
Cerebellum development
(GO:0021549)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cytoplasm
(GO:0005737)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Epidermis development
(GO:0008544)
Glucose homeostasis
(GO:0042593)
Granular component
(GO:0001652)
Keratinocyte differentiation
(GO:0030216)
Keratinocyte proliferation
(GO:0043616)
Mammary gland epithelial cell proliferation
(GO:0033598)
Mdm2/mdm4 family protein binding
(GO:0097371)
Mitochondrial depolarization
(GO:0051882)
Mitochondrion
(GO:0005739)
Negative regulation of b cell proliferation
(GO:0030889)
Negative regulation of cell-matrix adhesion
(GO:0001953)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hepatocyte proliferation
(GO:2000346)
Negative regulation of immature t cell proliferation in thymus
(GO:0033088)
Negative regulation of mammary gland epithelial cell proliferation
(GO:0033600)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of protein localization to nucleolus
(GO:1904750)
Negative regulation of protein neddylation
(GO:2000435)
Negative regulation of proteolysis involved in protein catabolic process
(GO:1903051)
Negative regulation of ribosome biogenesis
(GO:0090071)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Neurogenesis
(GO:0022008)
Nf-kappab binding
(GO:0051059)
Nuclear body
(GO:0016604)
Nuclear body organization
(GO:0030575)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oncogene-induced cell senescence
(GO:0090402)
P53 binding
(GO:0002039)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic process involved in mammary gland involution
(GO:0060058)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043517)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage apoptotic process
(GO:2000111)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein sumoylation
(GO:0033235)
Positive regulation of signal transduction by p53 class mediator
(GO:1901798)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein destabilization
(GO:0031648)
Protein k63-linked ubiquitination
(GO:0070534)
Protein kinase binding
(GO:0019901)
Protein localization to nucleolus
(GO:1902570)
Protein localization to nucleus
(GO:0034504)
Protein polyubiquitination
(GO:0000209)
Protein stabilization
(GO:0050821)
Ras protein signal transduction
(GO:0007265)
Regulation of apoptotic dna fragmentation
(GO:1902510)
Regulation of cell cycle
(GO:0051726)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Regulation of nucleocytoplasmic transport
(GO:0046822)
Regulation of protein export from nucleus
(GO:0046825)
Regulation of protein stability
(GO:0031647)
Regulation of protein targeting to mitochondrion
(GO:1903214)
Replicative senescence
(GO:0090399)
Response to caloric restriction
(GO:0061771)
Response to fatty acid
(GO:0070542)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to organonitrogen compound
(GO:0010243)
Response to salt stress
(GO:0009651)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rrna processing
(GO:0006364)
Rrna transcription
(GO:0009303)
Senescence-associated heterochromatin focus
(GO:0035985)
Somatic stem cell division
(GO:0048103)
Somatic stem cell population maintenance
(GO:0035019)
Sumo transferase activity
(GO:0019789)
Ubiquitin-protein transferase inhibitor activity
(GO:0055105)
Ubiquitin ligase inhibitor activity
(GO:1990948)

Other Information

Proteins

Cyclin-dependent kinase 4 inhibitor A

Genular Protein ID: 2907034831

Symbol: CDN2A_RAT

Name: Cyclin-dependent kinase 4 inhibitor A

UniProtKB Accession Codes:

Q9R0Z3

Database IDs:

Citations:

PubMed ID: 9032263

Title: Frequent aberrant methylation of p16INK4a in primary rat lung tumors.

PubMed ID: 9032263

DOI: 10.1128/mcb.17.3.1366

Sequence Information:

Length: 159
Mass: 17366
Checksum: 3C4CA920A1FEAEB6
Sequence:

MESSADRLAR AAALGREHEV RALLEAGASP NAPNTFGRTP IQVMMMGNVK VAALLLSYGA 
DSNCEDPTTL SRPVHDAARE GFLDTLVVLH QAGARLDVRD AWGRLPLDLA LERGHHDVVR 
YLRYLLSSAG NVSRVTDRHN FCSSTPRCLG LRGQPPKQR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdkn2a

Associated with

Other Information

Frequent aberrant methylation of p16INK4a in primary rat lung tumors. PubMed ID: 9032263

Database document:

PubMed ID: 9032263