Ghr | ENSRNOG00000015654 | NCBI 25235

Details for: Ghr

Gene ID: 25235

Symbol: Ghr

Ensembl ID: ENSRNOG00000015654

Description: growth hormone receptor

Associated with

Cytokine signaling in immune system
(R-RNO-1280215)
Growth hormone receptor signaling
(R-RNO-982772)
Immune system
(R-RNO-168256)
Prolactin receptor signaling
(R-RNO-1170546)
Cartilage development involved in endochondral bone morphogenesis
(GO:0060351)
Cell surface
(GO:0009986)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to insulin stimulus
(GO:0032869)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Growth factor binding
(GO:0019838)
Growth hormone receptor activity
(GO:0004903)
Growth hormone receptor complex
(GO:0070195)
Growth hormone receptor signaling pathway
(GO:0060396)
Hormone-mediated signaling pathway
(GO:0009755)
Hormone metabolic process
(GO:0042445)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Peptide hormone binding
(GO:0017046)
Plasma membrane
(GO:0005886)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Receptor complex
(GO:0043235)
Receptor internalization
(GO:0031623)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of multicellular organism growth
(GO:0040014)
Regulation of response to nutrient levels
(GO:0032107)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Response to estradiol
(GO:0032355)
Response to food
(GO:0032094)
Response to glucocorticoid
(GO:0051384)
Response to gravity
(GO:0009629)
Response to growth hormone
(GO:0060416)
Response to hormone
(GO:0009725)
Response to interleukin-1
(GO:0070555)
Response to peptide hormone
(GO:0043434)
Sh2 domain binding
(GO:0042169)
Taurine metabolic process
(GO:0019530)

Other Information

Proteins

Growth hormone receptor

Genular Protein ID: 4105185661

Symbol: GHR_RAT

Name: Growth hormone receptor

UniProtKB Accession Codes:

P16310 Q64236 Q80XW9

Database IDs:

Citations:

PubMed ID: 2722883

Title: Regulation of rat growth hormone receptor gene expression.

PubMed ID: 2722883

DOI: 10.1016/s0021-9258(18)81745-8

PubMed ID: 2792761

Title: The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

PubMed ID: 2792761

DOI: 10.1101/gad.3.8.1199

PubMed ID: 1446642

Title: Characterization of the short isoform of the growth hormone receptor synthesized by rat adipocytes.

PubMed ID: 1446642

DOI: 10.1210/endo.131.6.1446642

PubMed ID: 8921876

Title: Structural comparison of a portion of the rat and mouse growth hormone receptor/binding protein genes.

PubMed ID: 8921876

DOI: 10.1016/0378-1119(96)00277-6

PubMed ID: 8063815

Title: Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.

PubMed ID: 8063815

DOI: 10.1016/s0021-9258(17)31863-x

PubMed ID: 7615519

Title: Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation.

PubMed ID: 7615519

DOI: 10.1074/jbc.270.29.17210

PubMed ID: 10585430

Title: SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.

PubMed ID: 10585430

DOI: 10.1074/jbc.274.50.35553

PubMed ID: 7545168

Title: Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor.

PubMed ID: 7545168

DOI: 10.1074/jbc.270.37.21738

PubMed ID: 9231797

Title: Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B.

PubMed ID: 9231797

DOI: 10.1210/endo.138.8.5332

Sequence Information:

Length: 638
Mass: 71237
Checksum: 0D8E9AF759A21A3B
Sequence:

MDLWRVFLTL ALAVSSDMFP GSGATPATLG KASPVLQRIN PSLRESSSGK PRFTKCRSPE 
LETFSCYWTE GDDHNLKVPG SIQLYYARRI AHEWTPEWKE CPDYVSAGAN SCYFNSSYTS 
IWIPYCIKLT TNGDLLDEKC FTVDEIVQPD PPIGLNWTLL NISLPGIRGD IQVSWQPPPS 
ADVLKGWIIL EYEIQYKEVN ETKWKTMSPI WSTSVPLYSL RLDKEHEVRV RSRQRSFEKY 
SEFSEVLRVT FPQMDTLAAC EEDFRFPWFL IIIFGIFGVA VMLFVVIFSK QQRIKMLILP 
PVPVPKIKGI DPDLLKEGKL EEVNTILGIH DNYKPDFYND DSWVEFIELD IDDADEKTEE 
SDTDRLLSDD QEKSAGILGA KDDDSGRTSC YDPDILDTDF HTSDMCDGTS EFAQPQKLKA 
EADLLCLDQK NLKNSPYDAS LGSLHPSITL TMEDKPQPLL GSETESTHQL PSTPMSSPVS 
LANIDFYAQV SDITPAGGVV LSPGQKIKAG LAQGNTQLEV AAPCQENYSM NSAYFCESDA 
KKCIAAAPHM EATTCVKPSF NQEDIYITTE SLTTTARMSE TADTAPDAEP VPDYTTVHTV 
KSPRGLILNA TALPLPDKKK FLSSCGYVST DQLNKIMQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ghr

Associated with

Other Information

Regulation of rat growth hormone receptor gene expression. PubMed ID: 2722883

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor. PubMed ID: 2792761

Characterization of the short isoform of the growth hormone receptor synthesized by rat adipocytes. PubMed ID: 1446642

Structural comparison of a portion of the rat and mouse growth hormone receptor/binding protein genes. PubMed ID: 8921876

Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. PubMed ID: 8063815

Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation. PubMed ID: 7615519

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. PubMed ID: 10585430

Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor. PubMed ID: 7545168

Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B. PubMed ID: 9231797