Grk2 | ENSRNOG00000018985 | NCBI 25238

Details for: Grk2

Gene ID: 25238

Symbol: Grk2

Ensembl ID: ENSRNOG00000018985

Description: G protein-coupled receptor kinase 2

Associated with

Activation of smo
(R-RNO-5635838)
Ca-dependent events
(R-RNO-111996)
Calmodulin induced events
(R-RNO-111933)
Cam pathway
(R-RNO-111997)
Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Dag and ip3 signaling
(R-RNO-1489509)
G-protein mediated events
(R-RNO-112040)
G alpha (i) signalling events
(R-RNO-418594)
G alpha (q) signalling events
(R-RNO-416476)
G alpha (s) signalling events
(R-RNO-418555)
Gpcr downstream signalling
(R-RNO-388396)
Hedgehog 'on' state
(R-RNO-5632684)
Intracellular signaling by second messengers
(R-RNO-9006925)
Membrane trafficking
(R-RNO-199991)
Opioid signalling
(R-RNO-111885)
Plc beta mediated events
(R-RNO-112043)
Signaling by gpcr
(R-RNO-372790)
Signaling by hedgehog
(R-RNO-5358351)
Vesicle-mediated transport
(R-RNO-5653656)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Basolateral plasma membrane
(GO:0016323)
Beta-adrenergic receptor kinase activity
(GO:0047696)
Cardiac muscle contraction
(GO:0060048)
Caveola
(GO:0005901)
Cellular response to catecholamine stimulus
(GO:0071870)
Cellular response to chemokine
(GO:1990869)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to phorbol 13-acetate 12-myristate
(GO:1904628)
Cellular response to rapamycin
(GO:0072752)
Cytoplasm
(GO:0005737)
Delta-type opioid receptor binding
(GO:0031850)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Desensitization of g protein-coupled receptor signaling pathway
(GO:0002029)
Edg-2 lysophosphatidic acid receptor binding
(GO:0031755)
Follicle-stimulating hormone signaling pathway
(GO:0042699)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor kinase activity
(GO:0004703)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Kappa-type opioid receptor binding
(GO:0031851)
Maintenance of protein location in nucleus
(GO:0051457)
Membrane
(GO:0016020)
Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0106072)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cellular response to insulin stimulus
(GO:1900077)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of relaxation of smooth muscle
(GO:1901081)
Negative regulation of striated muscle contraction
(GO:0045988)
Negative regulation of the force of heart contraction by chemical signal
(GO:0003108)
Nucleus
(GO:0005634)
Oligodendrocyte differentiation
(GO:0048709)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of catecholamine secretion
(GO:0033605)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of muscle cell apoptotic process
(GO:0010661)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Positive regulation of vasoconstriction
(GO:0045907)
Postsynaptic density
(GO:0014069)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor internalization
(GO:0031623)
Regulation of the force of heart contraction
(GO:0002026)
Response to caloric restriction
(GO:0061771)
Response to hydrogen peroxide
(GO:0042542)
Response to leptin
(GO:0044321)
Response to muscle activity
(GO:0014850)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Scaffold protein binding
(GO:0097110)
Signal transduction
(GO:0007165)
Symbiont entry into host cell
(GO:0046718)
Tachykinin receptor signaling pathway
(GO:0007217)
Ubiquitin protein ligase binding
(GO:0031625)
Vasodilation
(GO:0042311)
Viral genome replication
(GO:0019079)

Other Information

Proteins

ARBK1_RAT

Genular Protein ID: 2047942994

Symbol: ARBK1_RAT

Name: N/A

UniProtKB Accession Codes:

P26817

Database IDs:

Citations:

PubMed ID: 1403099

Title: The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.

PubMed ID: 1403099

DOI: 10.1523/jneurosci.12-10-04045.1992

PubMed ID: 1436718

Title: Localization of mRNA for beta-adrenergic receptor kinase in the brain of adult rats.

PubMed ID: 1436718

DOI: 10.1016/0304-3940(92)90704-b

PubMed ID: 9826657

Title: Beta2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

PubMed ID: 9826657

DOI: 10.1073/pnas.95.24.14082

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 689
Mass: 79785
Checksum: 426A3335ACEB5A34
Sequence:

MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR GEVTFEKIFS 
QKLGYLLFRD FYLNHLEEAK PLVEFYEEIE KYEKLETEEE RVVRSREIFD SYIMKELLAC 
SHPFSKNATE HVQGHLVKKQ VPPDLFQPYI EEICQNLRGD VFHKFIESDK FTRFCQWKNV 
ELNIHLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 
IMLSLVSTGD CPFIVCMSYA FHTPDKLSFI LDLMNGGDLH YHLSQHGVFS EADMRFYAAE 
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE 
VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTMA VELPDSFSPE 
LRSLLEGLLQ RDVNRRLGCL GRGAQEIKES PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA 
DAFDIGSFDE EDTKGIKLLD SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK 
KAKNKQLGHE EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEDEAPQSL 
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF VLQCDSDPEL VQWKKELRDA YREAQQLVQR 
VPKMKNKPRS PVVELSKVPL IQRGSANGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grk2

Associated with

Other Information

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. PubMed ID: 1403099

Localization of mRNA for beta-adrenergic receptor kinase in the brain of adult rats. PubMed ID: 1436718

Beta2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. PubMed ID: 9826657

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Database document:

PubMed ID: 1403099

PubMed ID: 1436718

PubMed ID: 9826657

PubMed ID: 22673903