Cnr1 | ENSRNOG00000008223 | NCBI 25248

Details for: Cnr1

Gene ID: 25248

Symbol: Cnr1

Ensembl ID: ENSRNOG00000008223

Description: cannabinoid receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (i) signalling events
(R-RNO-418594)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Actin cytoskeleton
(GO:0015629)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Axon
(GO:0030424)
Axonal fasciculation
(GO:0007413)
Cannabinoid receptor activity
(GO:0004949)
Cannabinoid signaling pathway
(GO:0038171)
Cytoplasm
(GO:0005737)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Learning or memory
(GO:0007611)
Maternal process involved in female pregnancy
(GO:0060135)
Membrane raft
(GO:0045121)
Memory
(GO:0007613)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of action potential
(GO:0045759)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of dopamine secretion
(GO:0033602)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Negative regulation of mast cell activation
(GO:0033004)
Negative regulation of monoatomic ion transport
(GO:0043271)
Negative regulation of serotonin secretion
(GO:0014063)
Plasma membrane
(GO:0005886)
Positive regulation of acute inflammatory response to antigenic stimulus
(GO:0002866)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of neuron projection development
(GO:0010976)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Regulation of feeding behavior
(GO:0060259)
Regulation of insulin secretion
(GO:0050796)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of metabolic process
(GO:0019222)
Regulation of penile erection
(GO:0060405)
Regulation of presynaptic cytosolic calcium ion concentration
(GO:0099509)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Response to nutrient
(GO:0007584)
Retrograde trans-synaptic signaling by endocannabinoid
(GO:0098921)
Spermatogenesis
(GO:0007283)
Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
(GO:0099553)

Other Information

Proteins

Cannabinoid receptor 1

Genular Protein ID: 3070622880

Symbol: CNR1_RAT

Name: Cannabinoid receptor 1

UniProtKB Accession Codes:

P20272

Database IDs:

Citations:

PubMed ID: 2165569

Title: Structure of a cannabinoid receptor and functional expression of the cloned cDNA.

PubMed ID: 2165569

DOI: 10.1038/346561a0

PubMed ID: 8832654

Title: Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells.

PubMed ID: 8832654

DOI: 10.1016/0304-3940(96)12792-0

PubMed ID: 7876112

Title: An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.

PubMed ID: 7876112

DOI: 10.1074/jbc.270.8.3726

PubMed ID: 10362691

Title: Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.

PubMed ID: 10362691

DOI: 10.1152/ajpheart.1999.276.6.h2085

PubMed ID: 10891614

Title: Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice.

PubMed ID: 10891614

DOI: 10.1016/s0306-4522(00)00157-3

PubMed ID: 16033894

Title: Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types.

PubMed ID: 16033894

DOI: 10.1523/jneurosci.0442-05.2005

PubMed ID: 17895407

Title: CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

PubMed ID: 17895407

DOI: 10.1124/mol.107.039263

PubMed ID: 18077343

Title: Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

PubMed ID: 18077343

DOI: 10.1073/pnas.0706980105

PubMed ID: 21895628

Title: Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.

PubMed ID: 21895628

DOI: 10.1111/j.1476-5381.2011.01658.x

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 26671069

Title: Pharmacological blockade of cannabinoid CB1 receptors in diet-induced obesity regulates mitochondrial dihydrolipoamide dehydrogenase in muscle.

PubMed ID: 26671069

DOI: 10.1371/journal.pone.0145244

Sequence Information:

Length: 473
Mass: 52845
Checksum: E59A66AFE17B646C
Sequence:

MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 
KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEENIQCG ENFMDMECFM ILNPSQQLAI 
AVLSLTLGTF TVLENLLVLC VILHSRSLRC RPSYHFIGSL AVADLLGSVI FVYSFVDFHV 
FHRKDSPNVF LFKLGGVTAS FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL 
MWTIAIVIAV LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW 
KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL VVLIICWGPL 
LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL RSKDLRHAFR SMFPSCEGTA 
QPLDNSMGDS DCLHKHANNT ASMHRAAESC IKSTVKIAKV TMSVSTDTSA EAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cnr1

Associated with

Other Information

Structure of a cannabinoid receptor and functional expression of the cloned cDNA. PubMed ID: 2165569

Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells. PubMed ID: 8832654

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. PubMed ID: 7876112

Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. PubMed ID: 10362691

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice. PubMed ID: 10891614

Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types. PubMed ID: 16033894

CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. PubMed ID: 17895407

Hemopressin is an inverse agonist of CB1 cannabinoid receptors. PubMed ID: 18077343

Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. PubMed ID: 21895628

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

Pharmacological blockade of cannabinoid CB1 receptors in diet-induced obesity regulates mitochondrial dihydrolipoamide dehydrogenase in muscle. PubMed ID: 26671069