Dyrk1a | ENSRNOG00000001662 | NCBI 25255

Details for: Dyrk1a

Gene ID: 25255

Symbol: Dyrk1a

Ensembl ID: ENSRNOG00000001662

Description: dual specificity tyrosine phosphorylation regulated kinase 1A

Associated with

Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
G0 and early g1
(R-RNO-1538133)
Mitotic g1 phase and g1/s transition
(R-RNO-453279)
Actin binding
(GO:0003779)
Actin filament
(GO:0005884)
Amyloid-beta formation
(GO:0034205)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Calcineurin-nfat signaling cascade
(GO:0033173)
Chromatin remodeling
(GO:0006338)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytoskeleton
(GO:0005856)
Dendrite
(GO:0030425)
Histone h3t45 kinase activity
(GO:0140857)
Identical protein binding
(GO:0042802)
Microtubule
(GO:0005874)
Negative regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043518)
Negative regulation of dna methylation-dependent heterochromatin formation
(GO:0090310)
Negative regulation of microtubule polymerization
(GO:0031115)
Negative regulation of mrna splicing, via spliceosome
(GO:0048025)
Neurofilament
(GO:0005883)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear speck
(GO:0016607)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein deacetylation
(GO:0090312)
Positive regulation of rna splicing
(GO:0033120)
Protein import into nucleus
(GO:0006606)
Protein kinase activity
(GO:0004672)
Protein self-association
(GO:0043621)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of alternative mrna splicing, via spliceosome
(GO:0000381)
Regulation of cell growth involved in cardiac muscle cell development
(GO:0061050)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Ribonucleoprotein complex
(GO:1990904)
Rna polymerase ii ctd heptapeptide repeat kinase activity
(GO:0008353)
Tau protein binding
(GO:0048156)
Transcription coactivator activity
(GO:0003713)
Tubulin binding
(GO:0015631)

Other Information

Proteins

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Genular Protein ID: 4032902056

Symbol: DYR1A_RAT

Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

UniProtKB Accession Codes:

Q63470

Database IDs:

Citations:

PubMed ID: 8631952

Title: Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.

PubMed ID: 8631952

DOI: 10.1074/jbc.271.7.3488

PubMed ID: 9748265

Title: Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.

PubMed ID: 9748265

DOI: 10.1074/jbc.273.40.25893

PubMed ID: 18938227

Title: The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

PubMed ID: 18938227

DOI: 10.1016/j.neuroscience.2008.09.034

PubMed ID: 22767602

Title: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.

PubMed ID: 22767602

DOI: 10.1074/jbc.m112.355412

PubMed ID: 22998443

Title: Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

PubMed ID: 22998443

DOI: 10.1021/jm301034u

Sequence Information:

Length: 763
Mass: 85541
Checksum: CB5EC7EC4C1F9A47
Sequence:

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AAQMPHSHQY SDRRQPNISD QQVSALSYSD 
QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 
QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 
EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 
LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 
SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 
FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWSLKKTKD GKREYKPPGT 
RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 
KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 
HFAAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 
HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 
STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 
QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dyrk1a

Associated with

Other Information

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. PubMed ID: 8631952

Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. PubMed ID: 9748265

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. PubMed ID: 18938227