Pdgfa | ENSRNOG00000001312 | NCBI 25266

Details for: Pdgfa

Gene ID: 25266

Symbol: Pdgfa

Ensembl ID: ENSRNOG00000001312

Description: platelet derived growth factor subunit A

Associated with

Downstream signal transduction
(R-RNO-186763)
Hemostasis
(R-RNO-109582)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Raf/map kinase cascade
(R-RNO-5673001)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Signaling by pdgf
(R-RNO-186797)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Bone development
(GO:0060348)
Cell population proliferation
(GO:0008283)
Cell projection assembly
(GO:0030031)
Cell surface
(GO:0009986)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Collagen binding
(GO:0005518)
Digestive tract development
(GO:0048565)
Embryonic lung development
(GO:1990401)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hair follicle development
(GO:0001942)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Lung alveolus development
(GO:0048286)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Negative chemotaxis
(GO:0050919)
Negative regulation of phosphatidylinositol biosynthetic process
(GO:0010512)
Negative regulation of platelet activation
(GO:0010544)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor complex
(GO:1990265)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein autophosphorylation
(GO:0031954)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
(GO:0060683)
Regulation of dna biosynthetic process
(GO:2000278)
Regulation of glomerular mesangial cell proliferation
(GO:0072124)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of smooth muscle cell migration
(GO:0014910)
Response to estradiol
(GO:0032355)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to organic substance
(GO:0010033)
Response to retinoic acid
(GO:0032526)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Skin development
(GO:0043588)

Other Information

Proteins

Platelet-derived growth factor subunit A

Genular Protein ID: 1692310774

Symbol: PDGFA_RAT

Name: Platelet-derived growth factor subunit A

UniProtKB Accession Codes:

P28576

Database IDs:

Citations:

PubMed ID: 8318539

Title: Conservation in sequence and affinity of human and rodent PDGF ligands and receptors.

PubMed ID: 8318539

DOI: 10.1016/0167-4781(93)90127-y

PubMed ID: 8447423

Title: Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension.

PubMed ID: 8447423

DOI: 10.1152/ajplung.1993.264.2.l100

PubMed ID: 8469035

Title: The age-dependent proliferation of rat aortic smooth muscle cells is independent of differential splicing of PDGF A-chain mRNA.

PubMed ID: 8469035

DOI: 10.1016/0047-6374(93)90113-6

Sequence Information:

Length: 204
Mass: 23307
Checksum: FA413F74E86F742C
Sequence:

MRTWACLLLL GCGYLAHALA EEAEIPRELI ERLARSQIHS IRDLQRLLEI DSVGAEDALE 
TNLRAHGSHT VKHVPEKRPV PIRRKRSIEE AIPAVCKTRT VIYEIPRSQV DPTSANFLIW 
PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA 
TSNLNPDHRE EETGRRRESG KKRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.