Details for: Proc

Gene ID: 25268

Symbol: Proc

Ensembl ID: ENSRNOG00000014376

Description: protein C, inactivator of coagulation factors Va and VIIIa

Associated with

  • Cell surface interactions at the vascular wall
    (R-RNO-202733)
  • Common pathway of fibrin clot formation
    (R-RNO-140875)
  • Formation of fibrin clot (clotting cascade)
    (R-RNO-140877)
  • Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    (R-RNO-159854)
  • Gamma-carboxylation of protein precursors
    (R-RNO-159740)
  • Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
    (R-RNO-163841)
  • Hemostasis
    (R-RNO-109582)
  • Intrinsic pathway of fibrin clot formation
    (R-RNO-140837)
  • Metabolism of proteins
    (R-RNO-392499)
  • Post-translational protein modification
    (R-RNO-597592)
  • Post-translational protein phosphorylation
    (R-RNO-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-RNO-381426)
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
    (R-RNO-159782)
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
    (R-RNO-159763)
  • Blood coagulation
    (GO:0007596)
  • Calcium ion binding
    (GO:0005509)
  • Endoplasmic reticulum
    (GO:0005783)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Liver development
    (GO:0001889)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of blood coagulation
    (GO:0030195)
  • Negative regulation of coagulation
    (GO:0050819)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Oligopeptidase activity
    (GO:0070012)
  • Peptidase activity
    (GO:0008233)
  • Positive regulation of establishment of endothelial barrier
    (GO:1903142)
  • Protein catabolic process
    (GO:0030163)
  • Protein self-association
    (GO:0043621)
  • Proteolysis
    (GO:0006508)
  • Regulation of circulating fibrinogen levels
    (GO:0044537)
  • Serine-type endopeptidase activity
    (GO:0004252)

Other Information

Genular Protein ID: 569628593

Symbol: PROC_RAT

Name: Vitamin K-dependent protein C

UniProtKB Accession Codes:

P31394

Database IDs:

AGR 1 AlphaFoldDB 1 CDD 2 CTD 1 EC 2 EMBL 1 GO 18 Gene3D 3 GlyCosmos 1 GlyGen 1 InParanoid 1 InterPro 14 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 10 PROSITE-ProRule 3 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 8 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 1627650

Title: The cDNA cloning and mRNA expression of rat protein C.

PubMed ID: 1627650

DOI: 10.1016/0167-4781(92)90035-x

Sequence Information:

  • Length: 461
  • Mass: 51912
  • Checksum: 8A4CF93664EDACD5
  • Sequence:
    • MWQFRIFLLF ASTWGISGVS AHPDPVFSSS EGAHQVLRVR RANSFLEEVR AGSLERECME 
EICDFEEAQE IFQNVEDTLA FWIKYFDGDQ CSTPPLDHQC DSPCCGHGTC IDGLGGFSCS 
CDKGWEGRFC QQEMGFQDCR VKNGGCYHYC LEETRGRRCR CAPGYELADD HMHCRPTVNF 
PCGKLWKRTD KKRKNFKRDI DPEDEELELG PRIVNGTLTK QGDSPWQAIL LDSKKKLACG 
GVLIHTSWVL TAAHCLESSK KLTVRLGEYD LRRRDPWELD LDIKEVLVHP NYTRSNSDND 
IALLRLSQPA TLSKTIVPIC LPNSGLAQEL SQAGQETVVT GWGYQSDKVK DGRRNRTFIL 
TFIRIPLAAR NDCMQVMNNV VSENMLCAGI IGDTRDACDG DSGGPMVVFF RGTWFLVGLV 
SWGEGCGHLN NYGVYTKVGS YLKWIHSYIG ERDVSLKSPK L

Genular Protein ID: 752997800

Symbol: Q68FY8_RAT

Name: N/A

UniProtKB Accession Codes:

Q68FY8

Database IDs:

ARBA 22 AlphaFoldDB 1 CDD 2 CTD 1 EC 1 EMBL 4 GO 5 Gene3D 3 HOGENOM 1 InterPro 14 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PROSITE 13 PROSITE-ProRule 1 Pfam 3 Proteomes 1 RGD 2 RefSeq 2 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 3 TreeFam 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 461
  • Mass: 51827
  • Checksum: C0181CED046B584B
  • Sequence:
    • MWQFRIFLLF ASTWGISGVS AHPDPVFSSS EGAHQVLRVR RANSFLEEVR AGSLERECME 
EICDFEEAQE IFQNVEDTLA FWIKYFDGDQ CSTPPLDHQC DSPCCGHGTC IDGLGGFSCS 
CDKGWEGRFC QQEMGFQDCR VKNGGCYHYC LEETRGRRCA CAPGYELADD HMHCRPTVNF 
PCGKLWKRTD KKRKNFKRDI DPEDEELELG PRIVNGTLTK QGDSPWQAIL LDSKKKLACG 
GVLIHTSWVL TAAHCLESSK KLTVRLGEYD LRRRDPWELD LDIKEVLVHP NYTRSNSDND 
IALLRLSQPA TLSKTIVPIC LPNSGLAQEL SQAGQETVVT GWGYQSDKVK DGRRNRTFIL 
TFIRIPLAAR NDCMQVMNNV VSENMLCAGI IGDTRDACDG DSGGPMVVFF RGTWFLVGLV 
SWGEGCGHLN NYGVYTKVGS YLKWIHSYIG ERDVSLKSPK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.