Details for: Cyp24a1

Gene ID: 25279

Symbol: Cyp24a1

Ensembl ID: ENSRNOG00000013062

Description: cytochrome P450, family 24, subfamily a, polypeptide 1

Associated with

Other Information

Genular Protein ID: 2927012759

Symbol: CP24A_RAT

Name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

UniProtKB Accession Codes:

Q09128 Q498V4 Q63685

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 CDD 1 CTD 1 ChEBI 94 ChEMBL 1 DrugCentral 1 EC 6 EMBL 14 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 Rhea 52 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 eggNOG 1

Citations:

PubMed ID: 1991512

Title: Cloning and expression of cDNA encoding 25-hydroxyvitamin D3 24-hydroxylase.

PubMed ID: 1991512

DOI: 10.1016/0014-5793(91)80115-j

PubMed ID: 8418863

Title: Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase.

PubMed ID: 8418863

DOI: 10.1021/bi00052a011

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8036172

Title: Identification of a vitamin D responsive element in the promoter of the rat cytochrome P450(24) gene.

PubMed ID: 8036172

DOI: 10.1093/nar/22.12.2410

PubMed ID: 2026586

Title: Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3.

PubMed ID: 2026586

DOI: 10.1016/s0021-9258(18)31501-1

PubMed ID: 10231362

Title: Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid.

PubMed ID: 10231362

DOI: 10.1046/j.1432-1327.1999.00375.x

PubMed ID: 15574355

Title: Metabolism of vitamin D3 by cytochromes P450.

PubMed ID: 15574355

DOI: 10.2741/1514

PubMed ID: 16617161

Title: Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats.

PubMed ID: 16617161

DOI: 10.1124/mol.106.023275

PubMed ID: 25727742

Title: Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.

PubMed ID: 25727742

DOI: 10.1016/j.jsbmb.2015.02.010

PubMed ID: 19961857

Title: Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.

PubMed ID: 19961857

DOI: 10.1016/j.jmb.2009.11.057

Sequence Information:

  • Length: 514
  • Mass: 59448
  • Checksum: 2E5CC1CCBA3C2B91
  • Sequence:
    • MSCPIDKRRT LIAFLRRLRD LGQPPRSVTS KASASRAPKE VPLCPLMTDG ETRNVTSLPG 
PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK LGSFDSVHLG SPSLLEALYR 
TESAHPQRLE IKPWKAYRDH RNEAYGLMIL EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN 
EVLADFLERM DELCDERGRI PDLYSELNKW SFESICLVLY EKRFGLLQKE TEEEALTFIT 
AIKTMMSTFG KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDNRL QRYSQQPGAD 
FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQAQR RLLQEVQSVL 
PDNQTPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK PTVLGEYALP KGTVLTLNTQ 
VLGSSEDNFE DSHKFRPERW LQKEKKINPF AHLPFGIGKR MCIGRRLAEL QLHLALCWII 
QKYDIVATDN EPVEMLHLGI LVPSRELPIA FRPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.