Gclc | ENSRNOG00000006302 | NCBI 25283

Details for: Gclc

Gene ID: 25283

Symbol: Gclc

Ensembl ID: ENSRNOG00000006302

Description: glutamate-cysteine ligase, catalytic subunit

Associated with

Biological oxidations
(R-RNO-211859)
Glutathione conjugation
(R-RNO-156590)
Glutathione synthesis and recycling
(R-RNO-174403)
Metabolism
(R-RNO-1430728)
Phase ii - conjugation of compounds
(R-RNO-156580)
Adp binding
(GO:0043531)
Atp binding
(GO:0005524)
Blood vessel diameter maintenance
(GO:0097746)
Cell redox homeostasis
(GO:0045454)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to follicle-stimulating hormone stimulus
(GO:0071372)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to mechanical stimulus
(GO:0071260)
Cellular response to thyroxine stimulus
(GO:0097069)
Cysteine metabolic process
(GO:0006534)
Cytosol
(GO:0005829)
Glutamate-cysteine ligase activity
(GO:0004357)
Glutamate-cysteine ligase complex
(GO:0017109)
Glutamate binding
(GO:0016595)
Glutamate metabolic process
(GO:0006536)
Glutathione biosynthetic process
(GO:0006750)
Glutathione metabolic process
(GO:0006749)
L-ascorbic acid metabolic process
(GO:0019852)
Magnesium ion binding
(GO:0000287)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of hepatic stellate cell activation
(GO:2000490)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein ubiquitination
(GO:0031397)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein-containing complex binding
(GO:0044877)
Regulation of mitochondrial depolarization
(GO:0051900)
Response to activity
(GO:0014823)
Response to arsenic-containing substance
(GO:0046685)
Response to auditory stimulus
(GO:0010996)
Response to cadmium ion
(GO:0046686)
Response to heat
(GO:0009408)
Response to hormone
(GO:0009725)
Response to human chorionic gonadotropin
(GO:0044752)
Response to interleukin-1
(GO:0070555)
Response to nitrosative stress
(GO:0051409)
Response to nutrient
(GO:0007584)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

GCS heavy chain

Genular Protein ID: 2748834141

Symbol: GSH1_RAT

Name: GCS heavy chain

UniProtKB Accession Codes:

P19468

Database IDs:

Citations:

PubMed ID: 1967255

Title: Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase.

PubMed ID: 1967255

DOI: 10.1016/s0021-9258(19)40057-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 637
Mass: 72619
Checksum: 9F0AFA15684A5AE2
Sequence:

MGLLSQGSPL SWEETQRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 
ENRKVQLLLN GGDVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 
EDNMRKRRKE ATSVLGEHQA LCTITSFPRL GCPGFTLPEH RPNPEEGGAS KSLFFPDEAI 
NKHPRFGTLT RNIRHRRGEK VVINVPIFKD KNTPSPFVET FPEDEEASKA SKPDHIYMDA 
MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 
SASVDDRTRE ERGLEPLKNN RFKISKSRYD SIDSYLSKCG EKYNDIDLTI DTEIYEQLLE 
EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 
GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQERDAVL 
QGMFYFRKDI CKGGNAVVDG CSKAQTSSEP SAEEYTLMSI DTIINGKEGV FPGLIPILNS 
YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEINYS 
LILKCNQIAN ELCECPELLG SGFRKAKYSG GKSDPSD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.