Alox5 | ENSRNOG00000012972 | NCBI 25290

Details for: Alox5

Gene ID: 25290

Symbol: Alox5

Ensembl ID: ENSRNOG00000012972

Description: arachidonate 5-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Biosynthesis of aspirin-triggered d-series resolvins
(R-RNO-9020265)
Biosynthesis of d-series resolvins
(R-RNO-9018676)
Biosynthesis of dha-derived spms
(R-RNO-9018677)
Biosynthesis of dpa-derived spms
(R-RNO-9018683)
Biosynthesis of dpan-3 spms
(R-RNO-9025094)
Biosynthesis of dpan-3-derived 13-series resolvins
(R-RNO-9026403)
Biosynthesis of dpan-3-derived maresins
(R-RNO-9026290)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-RNO-9026286)
Biosynthesis of e-series 18(r)-resolvins
(R-RNO-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-RNO-9018896)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-RNO-9027604)
Biosynthesis of epa-derived spms
(R-RNO-9018679)
Biosynthesis of maresins
(R-RNO-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-RNO-9018678)
Fatty acid metabolism
(R-RNO-8978868)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Neutrophil degranulation
(R-RNO-6798695)
Synthesis of 5-eicosatetraenoic acids
(R-RNO-2142688)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-RNO-2142691)
Synthesis of lipoxins (lx)
(R-RNO-2142700)
Arachidonate 5-lipoxygenase activity
(GO:0004051)
Arachidonate 8(s)-lipoxygenase activity
(GO:0036403)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonic acid metabolic process
(GO:0019369)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Dendritic cell migration
(GO:0036336)
Glucose homeostasis
(GO:0042593)
Hepoxilin biosynthetic process
(GO:0051122)
Humoral immune response
(GO:0006959)
Hydrolase activity
(GO:0016787)
Inflammatory response
(GO:0006954)
Iron ion binding
(GO:0005506)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Leukotriene a4 biosynthetic process
(GO:1901753)
Leukotriene biosynthetic process
(GO:0019370)
Leukotriene metabolic process
(GO:0006691)
Leukotriene production involved in inflammatory response
(GO:0002540)
Linoleic acid metabolic process
(GO:0043651)
Lipid oxidation
(GO:0034440)
Lipoxin biosynthetic process
(GO:2001301)
Lipoxygenase pathway
(GO:0019372)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Negative regulation of vascular wound healing
(GO:0061044)
Negative regulation of wound healing
(GO:0061045)
Nuclear envelope
(GO:0005635)
Nuclear envelope lumen
(GO:0005641)
Nuclear matrix
(GO:0016363)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of leukocyte adhesion to arterial endothelial cell
(GO:1904999)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of inflammatory response
(GO:0050727)
Regulation of inflammatory response to wounding
(GO:0106014)
Regulation of insulin secretion
(GO:0050796)
Regulation of reactive oxygen species biosynthetic process
(GO:1903426)
Response to hyperoxia
(GO:0055093)
Response to nutrient
(GO:0007584)
Sarcolemma
(GO:0042383)

Other Information

Proteins

Arachidonate 5-lipoxygenase

Genular Protein ID: 3425989969

Symbol: LOX5_RAT

Name: Arachidonate 5-lipoxygenase

UniProtKB Accession Codes:

P12527

Database IDs:

Citations:

PubMed ID: 3417684

Title: Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.

PubMed ID: 3417684

DOI: 10.1016/s0021-9258(18)68334-6

PubMed ID: 8518276

Title: Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1.

PubMed ID: 8518276

DOI: 10.1021/bi00076a003

Sequence Information:

Length: 673
Mass: 78087
Checksum: 536B0BC27CB0A608
Sequence:

MPSYTVTVAT GSQWFAGTDD YIYLSLIGSA GCSEKHLLDK AFYNDFERGG RDSYDVTVDE 
ELGEIYLVKI EKRKYRLHDD WYLKYITLKT PHDYIEFPCY RWITGEGEIV LRDGCAKLAR 
DDQIHILKQH RRKELETRQK QYRWMEWNPG FPLSIDAKCH KDLPRDIQFD SEKGVDFVLN 
YSKAMENLFI NRFMHMFQSS WHDFADFEKI FVKISNTISE RVKNHWQEDL MFGYQFLNGC 
NPVLIKRCTE LPKKLPVTTE MVECSLERQL SLEQEVQEGN IFIVDYELLD GIDANKTDPC 
THQFLAAPIC LLYKNLANKI VPIAIQLNQT PGEKNPIFLP TDSKYDWLLA KIWVRSSDFH 
IHQTITHLLR THLVSEVFGI AMYRQLPAVH PLFKLLVAHV RFTIAINTKA REQLNCEYGL 
FDKANATGGG GHVQMVQRAV QDLTYSSLCF PEAIKARGMD NTEDIPYYFY RDDGLLVWEA 
IQSFTTEVVS IYYEDDQVVE EDQELQDFVK DVYVYGMRGR KASGFPKSIK SREKLSEYLT 
VVIFTASAQH AAVNFGQYDW CSWIPNAPPT MRAPPPTAKG VVTIEQIVDT LPDRGRSCWH 
LGAVWALSQF QENELFLGMY PEEHFIEKPV KEAMIRFRKN LEAIVSVIAE RNKNKKLPYY 
YLSPDRIPNS VAI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.