Chrna7 | ENSRNOG00000010853 | NCBI 25302

Details for: Chrna7

Gene ID: 25302

Symbol: Chrna7

Ensembl ID: ENSRNOG00000010853

Description: cholinergic receptor nicotinic alpha 7 subunit

Associated with

Acetylcholine binding and downstream events
(R-RNO-181431)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-RNO-629594)
Neuronal system
(R-RNO-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-RNO-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-RNO-622327)
Transmission across chemical synapses
(R-RNO-112315)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor activity
(GO:0015464)
Acetylcholine receptor signaling pathway
(GO:0095500)
Adenylate cyclase binding
(GO:0008179)
Amyloid-beta binding
(GO:0001540)
Associative learning
(GO:0008306)
Atpase binding
(GO:0051117)
B cell activation
(GO:0042113)
Behavioral response to ethanol
(GO:0048149)
Behavioral response to nicotine
(GO:0035095)
Calcium ion transport
(GO:0006816)
Chemical synaptic transmission
(GO:0007268)
Chloride channel regulator activity
(GO:0017081)
Cognition
(GO:0050890)
Dendrite arborization
(GO:0140059)
Dendritic spine organization
(GO:0097061)
Dopamine biosynthetic process
(GO:0042416)
Endocytosis
(GO:0006897)
Establishment of localization in cell
(GO:0051649)
Excitatory postsynaptic potential
(GO:0060079)
Flagellated sperm motility
(GO:0030317)
Generation of ovulation cycle rhythm
(GO:0060112)
Intracellular calcium ion homeostasis
(GO:0006874)
Learning or memory
(GO:0007611)
Memory
(GO:0007613)
Modulation of chemical synaptic transmission
(GO:0050804)
Modulation of excitatory postsynaptic potential
(GO:0098815)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nervous system process
(GO:0050877)
Neuronal action potential
(GO:0019228)
Ovulation cycle
(GO:0042698)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
(GO:0001988)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of protein phosphorylation
(GO:0001934)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of amyloid precursor protein catabolic process
(GO:1902991)
Regulation of inflammatory response
(GO:0050727)
Regulation of membrane potential
(GO:0042391)
Regulation of norepinephrine secretion
(GO:0014061)
Regulation of synapse structural plasticity
(GO:0051823)
Regulation of synaptic transmission, dopaminergic
(GO:0032225)
Response to carbamate
(GO:0046681)
Response to cold
(GO:0009409)
Response to ethanol
(GO:0045471)
Response to food
(GO:0032094)
Response to hypoxia
(GO:0001666)
Response to nicotine
(GO:0035094)
Scaffold protein binding
(GO:0097110)
Sensory processing
(GO:0050893)
Signal transduction
(GO:0007165)
Synapse organization
(GO:0050808)
Synaptic transmission, cholinergic
(GO:0007271)
T cell activation
(GO:0042110)
Toxic substance binding
(GO:0015643)
Transmembrane signaling receptor activity
(GO:0004888)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Neuronal acetylcholine receptor subunit alpha-7

Genular Protein ID: 3917165908

Symbol: ACHA7_RAT

Name: Neuronal acetylcholine receptor subunit alpha-7

UniProtKB Accession Codes:

Q05941 Q53YK2

Database IDs:

Citations:

PubMed ID: 7678857

Title: Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium.

PubMed ID: 7678857

DOI: 10.1523/jneurosci.13-02-00596.1993

PubMed ID: 15927954

Title: Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.

PubMed ID: 15927954

DOI: 10.1074/jbc.m503746200

PubMed ID: 16120769

Title: RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

PubMed ID: 16120769

DOI: 10.1124/mol.105.017459

PubMed ID: 25740413

Title: Molecular interaction of alpha-conotoxin RgIA with the rat alpha9alpha10 nicotinic acetylcholine receptor.

PubMed ID: 25740413

DOI: 10.1124/mol.114.096511

PubMed ID: 27559150

Title: Corrections to 'Molecular interaction of alpha-conotoxin RgIA with the rat alpha9alpha10 nicotinic acetylcholine receptor'.

PubMed ID: 27559150

DOI: 10.1124/mol.114.096511err

Sequence Information:

Length: 502
Mass: 56503
Checksum: 289A30498C7B9A58
Sequence:

MCGGRGGIWL ALAAALLHVS LQGEFQRRLY KELVKNYNPL ERPVANDSQP LTVYFSLSLL 
QIMDVDEKNQ VLTTNIWLQM SWTDHYLQWN MSEYPGVKNV RFPDGQIWKP DILLYNSADE 
RFDATFHTNV LVNASGHCQY LPPGIFKSSC YIDVRWFPFD VQQCKLKFGS WSYGGWSLDL 
QMQEADISSY IPNGEWDLMG IPGKRNEKFY ECCKEPYPDV TYTVTMRRRT LYYGLNLLIP 
CVLISALALL VFLLPADSGE KISLGITVLL SLTVFMLLVA EIMPATSDSV PLIAQYFAST 
MIIVGLSVVV TVIVLRYHHH DPDGGKMPKW TRIILLNWCA WFLRMKRPGE DKVRPACQHK 
PRRCSLASVE LSAGAGPPTS NGNLLYIGFR GLEGMHCAPT PDSGVVCGRL ACSPTHDEHL 
MHGAHPSDGD PDLAKILEEV RYIANRFRCQ DESEVICSEW KFAACVVDRL CLMAFSVFTI 
ICTIGILMSA PNFVEAVSKD FA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrna7

Associated with

Other Information

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. PubMed ID: 7678857

Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. PubMed ID: 15927954

RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. PubMed ID: 16120769