Abcc2 | ENSRNOG00000046727 | NCBI 25303

Details for: Abcc2

Gene ID: 25303

Symbol: Abcc2

Ensembl ID: ENSRNOG00000046727

Description: ATP binding cassette subfamily C member 2

Associated with

Abc-family proteins mediated transport
(R-RNO-382556)
Aspirin adme
(R-RNO-9749641)
Atorvastatin adme
(R-RNO-9754706)
Drug adme
(R-RNO-9748784)
Heme degradation
(R-RNO-189483)
Metabolism
(R-RNO-1430728)
Metabolism of porphyrins
(R-RNO-189445)
Paracetamol adme
(R-RNO-9753281)
Transport of small molecules
(R-RNO-382551)
Abc-type glutathione s-conjugate transporter activity
(GO:0015431)
Abc-type transporter activity
(GO:0140359)
Abc-type xenobiotic transporter activity
(GO:0008559)
Antibiotic metabolic process
(GO:0016999)
Apical plasma membrane
(GO:0016324)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Benzylpenicillin metabolic process
(GO:1901086)
Bile acid and bile salt transport
(GO:0015721)
Bile acid signaling pathway
(GO:0038183)
Bilirubin transmembrane transporter activity
(GO:0015127)
Bilirubin transport
(GO:0015723)
Brush border membrane
(GO:0031526)
Canalicular bile acid transport
(GO:0015722)
Cell surface
(GO:0009986)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to interleukin-6
(GO:0071354)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to xenobiotic stimulus
(GO:0071466)
Detoxification of mercury ion
(GO:0050787)
Female pregnancy
(GO:0007565)
Intercellular canaliculus
(GO:0046581)
Intracellular canaliculus
(GO:0046691)
Intracellular chloride ion homeostasis
(GO:0030644)
Leukotriene transport
(GO:0071716)
Membrane
(GO:0016020)
Mercury ion transport
(GO:0015694)
Negative regulation of gene expression
(GO:0010629)
Organic anion transmembrane transporter activity
(GO:0008514)
Organic anion transport
(GO:0015711)
Plasma membrane
(GO:0005886)
Prostaglandin transport
(GO:0015732)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of bile acid secretion
(GO:0120188)
Response to antineoplastic agent
(GO:0097327)
Response to arsenic-containing substance
(GO:0046685)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Response to glucagon
(GO:0033762)
Response to lipopolysaccharide
(GO:0032496)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Response to steroid hormone
(GO:0048545)
Response to xenobiotic stimulus
(GO:0009410)
Thyroid hormone transport
(GO:0070327)
Transepithelial transport
(GO:0070633)
Transmembrane transport
(GO:0055085)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic detoxification by transmembrane export across the plasma membrane
(GO:1990961)
Xenobiotic export from cell
(GO:0046618)
Xenobiotic transmembrane transport
(GO:0006855)
Xenobiotic transmembrane transporter activity
(GO:0042910)
Xenobiotic transport across blood-brain barrier
(GO:1990962)

Other Information

Proteins

ATP-binding cassette sub-family C member 2

Genular Protein ID: 3442261591

Symbol: MRP2_RAT

Name: ATP-binding cassette sub-family C member 2

UniProtKB Accession Codes:

Q63120 Q63145

Database IDs:

Citations:

PubMed ID: 8599091

Title: Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

PubMed ID: 8599091

DOI: 10.1126/science.271.5252.1126

PubMed ID: 8662992

Title: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

PubMed ID: 8662992

DOI: 10.1074/jbc.271.25.15091

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 10421658

Title: Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.

PubMed ID: 10421658

DOI: 10.1002/hep.510300220

PubMed ID: 10220572

Title: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

PubMed ID: 10220572

PubMed ID: 11248200

Title: Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.

PubMed ID: 11248200

DOI: 10.1016/s0005-2736(00)00355-2

Sequence Information:

Length: 1541
Mass: 173384
Checksum: D5FB55571BFDDB39
Sequence:

MDKFCNSTFW DLSLLESPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYSV YRSRTKRSSI 
TKFYLAKQVF VVFLLILAAI DLSLALTEDT GQATVPPVRY TNPILYLCTW LLVLAVQHSR 
QWCVRKNSWF LSLFWILSVL CGVFQFQTLI RALLKDSKSN MAYSYLFFVS YGFQIVLLIL 
TAFSGPSDST QTPSVTASFL SSITFSWYDR TVLKGYKHPL TLEDVWDIDE GFKTRSVTSK 
FEAAMTKDLQ KARQAFQRRL QKSQRKPEAT LHGLNKKQSQ SQDVLVLEEA KKKSEKTTKD 
YPKSWLIKSL FKTFHVVILK SFILKLIHDL LVFLNPQLLK LLIGFVKSSN SYVWFGYICA 
ILMFAVTLIQ SFCLQSYFQH CFVLGMCVRT TVMSSIYKKA LTLSNLARKQ YTIGETVNLM 
SVDSQKLMDA TNYMQLVWSS VIQITLSIFF LWRELGPSIL AGVGVMVLLI PVNGVLATKI 
RNIQVQNMKN KDKRLKIMNE ILSGIKILKY FAWEPSFQEQ VQGIRKKELK NLLRFGQLQS 
LLIFILQITP ILVSVVTFSV YVLVDSANVL NAEKAFTSIT LFNILRFPLS MLPMVTSSIL 
QASVSVDRLE RYLGGDDLDT SAIRRVSNFD KAVKFSEASF TWDPDLEATI QDVNLDIKPG 
QLVAVVGTVG SGKSSLVSAM LGEMENVHGH ITIQGSTAYV PQQSWIQNGT IKDNILFGSE 
YNEKKYQQVL KACALLPDLE ILPGGDMAEI GEKGINLSGG QKQRVSLARA AYQDADIYIL 
DDPLSAVDAH VGKHIFNKVV GPNGLLAGKT RIFVTHGIHF LPQVDEIVVL GKGTILEKGS 
YRDLLDKKGV FARNWKTFMK HSGPEGEATV NNDSEAEDDD DGLIPTMEEI PEDAASLAMR 
RENSLRRTLS RSSRSSSRRG KSLKNSLKIK NVNVLKEKEK EVEGQKLIKK EFVETGKVKF 
SIYLKYLQAV GWWSILFIIL FYGLNNVAFI GSNLWLSAWT SDSDNLNGTN NSSSHRDMRI 
GVFGALGLAQ GICLLISTLW SIYACRNASK ALHGQLLTNI LRAPMRFFDT TPTGRIVNRF 
SGDISTVDDL LPQTLRSWMM CFFGIAGTLV MICMATPVFA IIIIPLSILY ISVQVFYVAT 
SRQLRRLDSV TKSPIYSHFS ETVTGLPIIR AFEHQQRFLA WNEKQIDINQ KCVFSWITSN 
RWLAIRLELV GNLVVFCSAL LLVIYRKTLT GDVVGFVLSN ALNITQTLNW LVRMTSEAET 
NIVAVERISE YINVENEAPW VTDKRPPADW PRHGEIQFNN YQVRYRPELD LVLKGITCNI 
KSGEKVGVVG RTGAGKSSLT NCLFRILESA GGQIIIDGID VASIGLHDLR ERLTIIPQDP 
ILFSGSLRMN LDPFNKYSDE EVWRALELAH LRSFVSGLQL GLLSEVTEGG DNLSIGQRQL 
LCLGRAVLRK SKILVLDEAT AAVDLETDSL IQTTIRKEFS QCTVITIAHR LHTIMDSDKI 
MVLDNGKIVE YGSPEELLSN RGSFYLMAKE AGIENVNHTE L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcc2

Associated with

Other Information

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. PubMed ID: 8599091

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. PubMed ID: 8662992

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. PubMed ID: 10421658

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. PubMed ID: 10220572