Egf | ENSRNOG00000053979 | NCBI 25313

Details for: Egf

Gene ID: 25313

Symbol: Egf

Ensembl ID: ENSRNOG00000053979

Description: epidermal growth factor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Downregulation of erbb2 signaling
(R-RNO-8863795)
Egfr downregulation
(R-RNO-182971)
Egfr interacts with phospholipase c-gamma
(R-RNO-212718)
Erbb2 activates ptk6 signaling
(R-RNO-8847993)
Erbb2 regulates cell motility
(R-RNO-6785631)
Esr-mediated signaling
(R-RNO-8939211)
Extra-nuclear estrogen signaling
(R-RNO-9009391)
Gab1 signalosome
(R-RNO-180292)
Grb2 events in egfr signaling
(R-RNO-179812)
Hemostasis
(R-RNO-109582)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Membrane trafficking
(R-RNO-199991)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Notch3 activation and transmission of signal to the nucleus
(R-RNO-9013507)
Pi3k events in erbb2 signaling
(R-RNO-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Raf/map kinase cascade
(R-RNO-5673001)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Shc1 events in egfr signaling
(R-RNO-180336)
Shc1 events in erbb2 signaling
(R-RNO-1250196)
Signaling by egfr
(R-RNO-177929)
Signaling by erbb2
(R-RNO-1227986)
Signaling by erbb4
(R-RNO-1236394)
Signaling by non-receptor tyrosine kinases
(R-RNO-9006927)
Signaling by notch
(R-RNO-157118)
Signaling by notch3
(R-RNO-9012852)
Signaling by nuclear receptors
(R-RNO-9006931)
Signaling by ptk6
(R-RNO-8848021)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Vesicle-mediated transport
(R-RNO-5653656)
Anatomical structure development
(GO:0048856)
Angiogenesis
(GO:0001525)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Cell population proliferation
(GO:0008283)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell proliferation
(GO:0050673)
Erbb2-egfr signaling pathway
(GO:0038134)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular signal transduction
(GO:0035556)
Kidney development
(GO:0001822)
Mammary gland alveolus development
(GO:0060749)
Membrane
(GO:0016020)
Negative regulation of cholesterol efflux
(GO:0090370)
Negative regulation of secretion
(GO:0051048)
Plasma membrane
(GO:0005886)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of epithelial tube formation
(GO:1905278)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of hyaluronan biosynthetic process
(GO:1900127)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein localization to early endosome
(GO:1902966)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Receptor ligand activity
(GO:0048018)
Regulation of calcium ion import
(GO:0090279)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of protein localization to cell surface
(GO:2000008)
Regulation of protein transport
(GO:0051223)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Other Information

Proteins

Pro-epidermal growth factor

Genular Protein ID: 1552255256

Symbol: EGF_RAT

Name: Pro-epidermal growth factor

UniProtKB Accession Codes:

P07522 Q63183

Database IDs:

Citations:

PubMed ID: 1524680

Title: Cloning and sequencing of the rat preproepidermal growth factor cDNA: comparison with mouse and human sequences.

PubMed ID: 1524680

DOI: 10.1089/dna.1992.11.481

PubMed ID: 3000782

Title: Rat epidermal growth factor: complete amino acid sequence. Homology with the corresponding murine and human proteins; isolation of a form truncated at both ends with full in vitro biological activity.

PubMed ID: 3000782

DOI: 10.1111/j.1432-1033.1985.tb09346.x

PubMed ID: 3262867

Title: Cloning and sequence analysis of a cDNA for rat epidermal growth factor.

PubMed ID: 3262867

DOI: 10.1093/nar/16.19.9338

Sequence Information:

Length: 1133
Mass: 124126
Checksum: C224A302E9578031
Sequence:

MLFSLTFLSV FLKITVLSVT AQQTRNCQSG PLERSGTTTY AAAGPPRFLI FLQGNSIFRI 
NTDGTNHQQL VVDAGVSVVM DFHYKEERLY WVDLERQLLQ RVFFNGSGQE TVCKVDKNVS 
GLAINWIDGE ILRTDRWKGV ITVTDMNGNN SRVLLSSLKR PANILVDPTE RLIFWSSVVT 
GNLHRADLGG MDVKTLLEAP ERISVLILDI LDKRLFWAQD GREGSHGYIH SCDYNGGSIH 
HIRHQARHDL LTMAIFGDKI LYSALKEKAI WIADKHTGKN VVRVNLDPAS VPPRELRVVH 
LHAQPGTENR AQASDSERCK QRRGQCLYSL SERDPNSDSS ACAEGYTLSR DRKYCEDVNE 
CALQNHGCTL GCENIPGSYY CTCPTGFVLL PDGKRCHELV ACPGNRSECS HDCILTSDGP 
LCICPAGSVL GKDGKTCTGC SFSDNGGCSQ ICLPLSLASW ECDCFPGYDL QLDRKSCAAS 
MGPQPFLLFA NSQDIRHMHF DGTDYKTLLS RQMGMVFALD YDPVESKIYF AQTALKWIER 
ANLDGSQRER RITEGVDTPE GLAVDWIGRR IYWTDSGKSV IEGSDLSGKH HQIIIKESIS 
RPRGIAVHPK ARRLFWTDTG MSPRIESSSL QGSDRTLIAS SNLLEPSGIA IDYLTDTLYW 
CDTKLSVIEM ADLDGSKRRR LTQNDVGHPF SLAVFEDHVW FSDWAIPSVI RVNKRTGQNR 
VRLRGSMLKP SSLVVVHPLA KPGADPCLHR NGGCEHICQE SLGTAQCLCR EGFVKAPDGK 
MCLTRKDDQI LAGDNADLSK EVASLDNSPK AYVPDDDRTE SSTLVAEIMV SGLNYEDDCG 
PGGCGSHAHC ISEGEAAVCQ CLKGFAGDGN LCSDIDECEL GSSDCPPTSS RCINTEGGYV 
CQCSEGYEGD GIYCLDVDEC QQGSHGCSEN ATCTNTEGGY NCTCAGCPSA PGLPCPDSTS 
PSLLGKDGCH WVRNSNTGCP PSYDGYCLNG GVCMYVESVD RYVCNCVIGY IGERCQHRDL 
RWWKLRHADY GQRHDITVVS VCVVALALLL LLGMWGTYYY RTRKQLSESS KKPSEESSSN 
VSSNGPDSSG AGVSSGPQPW FVVLEEHQQP KNGRLPAAGT NGAVVEAGLS SSL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.