Details for: Il10

Gene ID: 25325

Symbol: Il10

Ensembl ID: ENSRNOG00000004647

Description: interleukin 10

Associated with

  • Cytokine signaling in immune system
    (R-RNO-1280215)
  • Immune system
    (R-RNO-168256)
  • Interleukin-10 signaling
    (R-RNO-6783783)
  • Signaling by interleukins
    (R-RNO-449147)
  • Branching involved in labyrinthine layer morphogenesis
    (GO:0060670)
  • Cellular response to antibiotic
    (GO:0071236)
  • Cellular response to estradiol stimulus
    (GO:0071392)
  • Cellular response to hepatocyte growth factor stimulus
    (GO:0035729)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to virus
    (GO:0098586)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Cytokine activity
    (GO:0005125)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to protozoan
    (GO:0042832)
  • Extracellular space
    (GO:0005615)
  • Immune response
    (GO:0006955)
  • Interleukin-10 receptor binding
    (GO:0005141)
  • Liver regeneration
    (GO:0097421)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002875)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of membrane protein ectodomain proteolysis
    (GO:0051045)
  • Negative regulation of mhc class ii biosynthetic process
    (GO:0045347)
  • Negative regulation of myeloid dendritic cell activation
    (GO:0030886)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of b cell apoptotic process
    (GO:0002904)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of plasma cell differentiation
    (GO:1900100)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of complement-dependent cytotoxicity
    (GO:1903659)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of response to wounding
    (GO:1903034)
  • Regulation of synapse organization
    (GO:0050807)
  • Response to activity
    (GO:0014823)
  • Response to carbon monoxide
    (GO:0034465)
  • Response to glucocorticoid
    (GO:0051384)
  • Response to inactivity
    (GO:0014854)
  • Response to insulin
    (GO:0032868)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to molecule of bacterial origin
    (GO:0002237)
  • Response to organic substance
    (GO:0010033)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 1771372842

Symbol: IL10_RAT

Name: Interleukin-10

UniProtKB Accession Codes:

P29456 Q63263

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CTD 1 EMBL 2 Ensembl 4 GO 60 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 1280414

Title: Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8-OX22-thoracic duct T cells.

PubMed ID: 1280414

DOI: 10.1016/0006-291x(92)91516-s

PubMed ID: 8484757

Title: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages.

PubMed ID: 8484757

DOI: 10.1006/bbrc.1993.1436

Sequence Information:

  • Length: 178
  • Mass: 20426
  • Checksum: 0225AA6C63DAB70B
  • Sequence:
    • MPGSALLCCL LLLAGVKTSK GHSIRGDNNC THFPVSQTHM LRELRAAFSQ VKTFFQKKDQ 
LDNILLTDSL LQDFKGYLGC QALSEMIKFY LVEVMPQAEN HGPEIKEHLN SLGEKLKTLW 
IQLRRCHRFL PCENKSKAVE QVKNDFNKLQ DKGVYKAMNE FDIFINCIEA YVTLKMKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.