Jak3 | ENSRNOG00000018669 | NCBI 25326

Details for: Jak3

Gene ID: 25326

Symbol: Jak3

Ensembl ID: ENSRNOG00000018669

Description: Janus kinase 3

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
Cytokine signaling in immune system
(R-RNO-1280215)
Gpcr ligand binding
(R-RNO-500792)
Immune system
(R-RNO-168256)
Interleukin-2 family signaling
(R-RNO-451927)
Interleukin-2 signaling
(R-RNO-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-RNO-512988)
Interleukin-4 and interleukin-13 signaling
(R-RNO-6785807)
Interleukin-7 signaling
(R-RNO-1266695)
Interleukin-9 signaling
(R-RNO-8985947)
Interleukin-15 signaling
(R-RNO-8983432)
Interleukin-20 family signaling
(R-RNO-8854691)
Interleukin-21 signaling
(R-RNO-9020958)
Interleukin receptor shc signaling
(R-RNO-912526)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Peptide ligand-binding receptors
(R-RNO-375276)
Raf/map kinase cascade
(R-RNO-5673001)
Relaxin receptors
(R-RNO-444821)
Signaling by alk
(R-RNO-201556)
Signaling by gpcr
(R-RNO-372790)
Signaling by interleukins
(R-RNO-449147)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
B cell differentiation
(GO:0030183)
Cell differentiation
(GO:0030154)
Cellular response to cytokine stimulus
(GO:0071345)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endomembrane system
(GO:0012505)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Growth hormone receptor binding
(GO:0005131)
Growth hormone receptor signaling pathway via jak-stat
(GO:0060397)
Innate immune response
(GO:0045087)
Interleukin-2-mediated signaling pathway
(GO:0038110)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Interleukin-9-mediated signaling pathway
(GO:0038113)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Intracellular signal transduction
(GO:0035556)
Negative regulation of complement-dependent cytotoxicity
(GO:1903660)
Negative regulation of dendritic cell cytokine production
(GO:0002731)
Negative regulation of fasl production
(GO:0045221)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of t-helper 1 cell differentiation
(GO:0045626)
Negative regulation of t cell activation
(GO:0050868)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Phosphorylation
(GO:0016310)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dendritic cell apoptotic process
(GO:2000670)
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001241)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of apoptotic process
(GO:0042981)
Regulation of t cell apoptotic process
(GO:0070232)
Response to interleukin-4
(GO:0070670)
T cell homeostasis
(GO:0043029)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Janus kinase 3

Genular Protein ID: 1715195823

Symbol: JAK3_RAT

Name: Janus kinase 3

UniProtKB Accession Codes:

Q63272 F1LR79

Database IDs:

Citations:

PubMed ID: 8143863

Title: Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases.

PubMed ID: 8143863

DOI: 10.1016/0014-5793(94)80485-0

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 1100
Mass: 122726
Checksum: F7FEBF8D91061C8A
Sequence:

MAPPSEETPL ISQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDYLA EDLCVRAAKA 
CGILPVYHSL FALATEDLSC WFPPSHIFSI EDVDTQVLVY RLRFYFPGWF GLETCHRFGL 
HKDLTSAILD VHVLEHLFAQ HRSDLVSGRL PVGLSLKDQG EFLSLAVLDL AQMARKQAQR 
PGELLKSVSY KACLPPSLRD LIQGQSFVTR RRIRRTVVQA LRRVVACQAD RYALMAKYIL 
DLERLHPAAT TESFLVGLPG AQEEPGCLRV TGDNGIAWSS KDQELFQTFC DFPEIVDVSI 
KQAPRVGPAG EHRLVTITRM DGHILEAEFP GLPEALSFVA LVDGYFRLIC DSRHFFCKEV 
APPRLLEEEA ELCHGPITLD FAIHKLKAAG SLPGSYILRR SPQDYDSFLL TACVQTPLGP 
DYKGCLIRQD PSGAFSLVGL SQLHRSLQEL LTACWHSGLQ VDGTALNLTS CCVPRPKEKS 
NLIVVRRGRN PTPAPGHSPS CCALTKLSFH TIPADSLEWH ENLGHGSFTK IFHGHRREVV 
DGETHDTEVL LKVMDSRHQN CMESFLEAAS LMSQVSYPHL VLLHGVCMAG DSIMVQEFVY 
LGAIDTYLRK RGHLVPASWK LQVTKQLAYA LNYLEDKGLP HGNVSARKVL LAREGVDGNP 
PFIKLSDPGV SPTVLSLEML TDRIPWVAPE CLQEAGTLNL EADKWGFGAT TWEVFSGAPM 
HITSLEPAKK LKFYEDRGQL PALKWTELEG LIAQCMAYDP GRRPSFRAIL RDLNGLITSD 
YELLSDPTPG IPNPRDELCG GAQLYACQDP AIFEERHLKY ISLLGKGNFG SVELCRYDPL 
GDNTGPLVAV KQLQHSGPEQ QRDFQREIQI LKALHCDFIV KYRGVSYGPG RQSLRLVMEY 
LPSGCLRDFL QRHRARLHND RLLLFAWQIC KGMEYLGARR CVHRDLAARN ILVESEAHVK 
IADFGLAKLL PLGKDYYVVR EPGQSPIFWY APESLSDNIF SRQSDVWSFG VVLYELFTYS 
DKSCSPSTEF LRMMGPEREG SPLCHLLELL AEGRRLPPPS TCPTEVQELM QLCWSPNPQD 
RPAFDTLSPQ LDALWRGSPG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.