Mat1a | ENSRNOG00000011351 | NCBI 25331

Details for: Mat1a

Gene ID: 25331

Symbol: Mat1a

Ensembl ID: ENSRNOG00000011351

Description: methionine adenosyltransferase 1A

Associated with

Biological oxidations
(R-RNO-211859)
Metabolism
(R-RNO-1430728)
Metabolism of amino acids and derivatives
(R-RNO-71291)
Metabolism of ingested semet, sec, mesec into h2se
(R-RNO-2408508)
Methylation
(R-RNO-156581)
Phase ii - conjugation of compounds
(R-RNO-156580)
Selenoamino acid metabolism
(R-RNO-2408522)
Sulfur amino acid metabolism
(R-RNO-1614635)
Adp binding
(GO:0043531)
Amino acid binding
(GO:0016597)
Atp binding
(GO:0005524)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Magnesium ion binding
(GO:0000287)
Metal ion binding
(GO:0046872)
Methionine adenosyltransferase activity
(GO:0004478)
Methionine adenosyltransferase complex
(GO:0048269)
Methionine catabolic process
(GO:0009087)
Nuclear matrix
(GO:0016363)
One-carbon metabolic process
(GO:0006730)
Protein-containing complex assembly
(GO:0065003)
Protein homotetramerization
(GO:0051289)
S-adenosylmethionine biosynthetic process
(GO:0006556)

Other Information

Proteins

S-adenosylmethionine synthase isoform type-1
F1LZ34_RAT

Genular Protein ID: 681258336

Symbol: METK1_RAT

Name: S-adenosylmethionine synthase isoform type-1

UniProtKB Accession Codes:

P13444 Q5FVU2

Database IDs:

Citations:

PubMed ID: 2806235

Title: Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase.

PubMed ID: 2806235

DOI: 10.1111/j.1432-1033.1989.tb15042.x

PubMed ID: 1915866

Title: Analysis of the 5' non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme.

PubMed ID: 1915866

DOI: 10.1016/0014-5793(91)81245-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1517209

Title: Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione.

PubMed ID: 1517209

DOI: 10.1016/s0021-9258(19)37084-x

PubMed ID: 9755242

Title: Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation.

PubMed ID: 9755242

DOI: 10.1002/hep.510280420

PubMed ID: 10358060

Title: Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol.

PubMed ID: 10358060

DOI: 10.1074/jbc.274.24.17075

PubMed ID: 10601859

Title: Assignment of a single disulfide bridge in rat liver methionine adenosyltransferase.

PubMed ID: 10601859

DOI: 10.1046/j.1432-1327.2000.00974.x

PubMed ID: 10873471

Title: The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.

PubMed ID: 10873471

DOI: 10.1006/jmbi.2000.3858

PubMed ID: 12888348

Title: Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism.

PubMed ID: 12888348

DOI: 10.1016/s0022-2836(03)00728-9

Sequence Information:

Length: 397
Mass: 43698
Checksum: A847A8CCBB2007BA
Sequence:

MNGPVDGLCD HSLSEEGAFM FTSESVGEGH PDKICDQISD AVLDAHLKQD PNAKVACETV 
CKTGMVLLCG EITSMAMIDY QRVVRDTIKH IGYDDSAKGF DFKTCNVLVA LEQQSPDIAQ 
CVHLDRNEED VGAGDQGLMF GYATDETEEC MPLTIVLAHK LNTRMADLRR SGVLPWLRPD 
SKTQVTVQYV QDNGAVIPVR VHTIVISVQH NEDITLEAMR EALKEQVIKA VVPAKYLDED 
TIYHLQPSGR FVIGGPQGDA GVTGRKIIVD TYGGWGAHGG GAFSGKDYTK VDRSAAYAAR 
WVAKSLVKAG LCRRVLVQVS YAIGVAEPLS ISIFTYGTSK KTERDELLEV VNKNFDLRPG 
VIVRDLDLKK PIYQKTACYG HFGRSEFPWE VPKKLVF

Genular Protein ID: 3885374078

Symbol: F1LZ34_RAT

Name: N/A

UniProtKB Accession Codes:

F1LZ34

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 396
Mass: 43583
Checksum: 4D7EB895E601E053
Sequence:

MNGPVDGLCD HSLSEEGAFM FTSESVGEGH PDKICDQISD AVLDAHLKQD PNAKVACETV 
CKTGMVLLCG EITSMAMIDY QRVVRDTIKH IGYDDSAKGF DFKTCNVLVA LEQQSPDIAQ 
CVHLDRNEED VGAGDQGLMF GYATDETEEC MPLTIVLAHK LNTRMADLRR SGVLPWLRPD 
SKTQVTVQYV QDNGAVIPVR VHTIVISVQH NEDITLEAMR EALKEQVIKA VVPAKYLDED 
TIYHLQPSGR FVIGGPQGDA GVTGRKIIVD TYGGWGAHGG GAFSGKDYTK VDRSAAYAAR 
WVAKSLVKAG LCRRVLVQVS YAIGVAEPLS ISIFTYGTSK KTERELLEVV NKNFDLRPGV 
IVRDLDLKKP IYQKTACYGH FGRSEFPWEV PKKLVF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mat1a

Associated with

Other Information

Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase. PubMed ID: 2806235

Analysis of the 5' non-coding region of rat liver S-adenosylmethionine synthetase mRNA and comparison of the Mr deduced from the cDNA sequence and the purified enzyme. PubMed ID: 1915866

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Modulation of rat liver S-adenosylmethionine synthetase activity by glutathione. PubMed ID: 1517209

Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation. PubMed ID: 9755242

Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol. PubMed ID: 10358060

Assignment of a single disulfide bridge in rat liver methionine adenosyltransferase. PubMed ID: 10601859

The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site. PubMed ID: 10873471

Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism. PubMed ID: 12888348

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822