Phb1 | ENSRNOG00000046799 | NCBI 25344

Details for: Phb1

Gene ID: 25344

Symbol: Phb1

Ensembl ID: ENSRNOG00000046799

Description: prohibitin 1

Associated with

Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Mitochondrial calcium ion transport
(R-RNO-8949215)
Processing of smdt1
(R-RNO-8949664)
Raf/map kinase cascade
(R-RNO-5673001)
Raf activation
(R-RNO-5673000)
Signal transduction
(R-RNO-162582)
Transport of small molecules
(R-RNO-382551)
Animal organ regeneration
(GO:0031100)
Antiviral innate immune response
(GO:0140374)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Cellular response to interleukin-6
(GO:0071354)
Complement component c3a binding
(GO:0001850)
Complement component c3b binding
(GO:0001851)
Cytoplasm
(GO:0005737)
Dna biosynthetic process
(GO:0071897)
Early endosome
(GO:0005769)
Enzyme binding
(GO:0019899)
Epigenetic regulation of gene expression
(GO:0040029)
Exocytic vesicle
(GO:0070382)
Extrinsic component of presynaptic active zone membrane
(GO:0098891)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Histone deacetylase binding
(GO:0042826)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial prohibitin complex
(GO:0035632)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Modulation by host of viral rna genome replication
(GO:0044830)
Negative regulation of androgen receptor signaling pathway
(GO:0060766)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucocorticoid receptor signaling pathway
(GO:2000323)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of transcription by competitive promoter binding
(GO:0010944)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ovarian follicle atresia
(GO:0001552)
Ovarian follicle development
(GO:0001541)
Plasma membrane
(GO:0005886)
Positive regulation of complement activation
(GO:0045917)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Postsynaptic density
(GO:0014069)
Progesterone receptor signaling pathway
(GO:0050847)
Proteinase activated receptor binding
(GO:0031871)
Protein heterodimerization activity
(GO:0046982)
Protein stabilization
(GO:0050821)
Regulation of dna-templated transcription
(GO:0006355)
Response to cytokine
(GO:0034097)
Response to ethanol
(GO:0045471)
Response to immobilization stress
(GO:0035902)
Response to peptide hormone
(GO:0043434)
Response to xenobiotic stimulus
(GO:0009410)
Rig-i signaling pathway
(GO:0039529)
Symbiont entry into host cell
(GO:0046718)
Synapse
(GO:0045202)
T-helper 17 type immune response
(GO:0072538)
Transcription corepressor activity
(GO:0003714)

Other Information

Proteins

Prohibitin 1

Genular Protein ID: 4051179624

Symbol: PHB1_RAT

Name: Prohibitin 1

UniProtKB Accession Codes:

P67779 P24142 Q4V8M6

Database IDs:

Citations:

PubMed ID: 1996099

Title: Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells.

PubMed ID: 1996099

DOI: 10.1128/mcb.11.3.1372-1381.1991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11302691

Title: Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.

PubMed ID: 11302691

DOI: 10.1006/excr.2001.5166

PubMed ID: 19423663

Title: Identification of novel immunodominant epididymal sperm proteins using combinatorial approach.

PubMed ID: 19423663

DOI: 10.1530/rep-09-0052

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 32173312

Title: Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells. in monocrotaline-induced PAH rats.

PubMed ID: 32173312

DOI: 10.1016/j.lfs.2020.117548

Sequence Information:

Length: 272
Mass: 29820
Checksum: 6B26073E169C2FFC
Sequence:

MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV GEGTHFLIPW 
VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA SQLPRIYTSI GEDYDERVLP 
SITTEILKSV VARFDAGELI TQRELVSRQV SDDLTERAAT FGLILDDVSL THLTFGKEFT 
EAVEAKQVAQ QEAERARFVV EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK 
LEAAEDIAYQ LSRSRNITYL PAGQSVLLQL PQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Phb1

Associated with

Other Information

Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. PubMed ID: 1996099

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. PubMed ID: 11302691

Identification of novel immunodominant epididymal sperm proteins using combinatorial approach. PubMed ID: 19423663

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903