Tshr | ENSRNOG00000003972 | NCBI 25360

Details for: Tshr

Gene ID: 25360

Symbol: Tshr

Ensembl ID: ENSRNOG00000003972

Description: thyroid stimulating hormone receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
Gpcr ligand binding
(R-RNO-500792)
Hormone ligand-binding receptors
(R-RNO-375281)
Signaling by gpcr
(R-RNO-372790)
Signal transduction
(R-RNO-162582)
Activation of adenylate cyclase activity
(GO:0007190)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adult locomotory behavior
(GO:0008344)
Basolateral plasma membrane
(GO:0016323)
B cell differentiation
(GO:0030183)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to glycoprotein
(GO:1904588)
Cellular response to thyrotropin-releasing hormone
(GO:1905229)
Cochlea morphogenesis
(GO:0090103)
Dopaminergic neuron differentiation
(GO:0071542)
G protein-coupled peptide receptor activity
(GO:0008528)
Hormone-mediated signaling pathway
(GO:0009755)
Inner ear receptor cell development
(GO:0060119)
Inner ear receptor cell stereocilium organization
(GO:0060122)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of multicellular organism growth
(GO:0040018)
Protein-containing complex binding
(GO:0044877)
Receptor complex
(GO:0043235)
Regulation of locomotion
(GO:0040012)
Signaling receptor activity
(GO:0038023)
Thyroid-stimulating hormone receptor activity
(GO:0004996)
Thyroid-stimulating hormone signaling pathway
(GO:0038194)

Other Information

Proteins

Thyrotropin receptor

Genular Protein ID: 756770751

Symbol: TSHR_RAT

Name: Thyrotropin receptor

UniProtKB Accession Codes:

P21463

Database IDs:

Citations:

PubMed ID: 1696008

Title: Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies.

PubMed ID: 1696008

DOI: 10.1073/pnas.87.15.5677

PubMed ID: 1332945

Title: Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.

PubMed ID: 1332945

DOI: 10.1016/s0021-9258(18)35740-5

PubMed ID: 12045258

Title: Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.

PubMed ID: 12045258

DOI: 10.1172/jci14340

Sequence Information:

Length: 764
Mass: 86475
Checksum: 79FC45CC9D26167B
Sequence:

MRPGSLLQLT LLLALPRSLW GRGCTSPPCE CHQEDDFRVT CKELHQIPSL PPSTQTLKLI 
ETHLKTIPSL AFSSLPNISR IYLSIDATLQ RLEPHSFYNL SKMTHIEIRN TRSLTYIDPD 
ALTELPLLKF LGIFNTGLRI FPDLTKIYST DVFFILEITD NPYMTSVPEN AFQGLCNETL 
TLKLYNNGFT SIQGHAFNGT KLDAVYLNKN KYLTAIDKDA FGGVYSGPTL LDVSSTSVTA 
LPSKGLEHLK ELIAKNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM 
CNESSIRNLR QRKSVNVMRG PVYQEYEEGL GDNHVGYKQN SKFQEGPSNS HYYVFFEEQE 
DEIIGFGQEL KNPQEETLQA FDSHYDYTVC GDNEDMVCTP KSDEFNPCED IMGYKFLRIV 
VWFVSPMALL GNVFVLFVLL TSHYKLTVPR FLMCNLAFAD FCMGVYLLLI ASVDLYTHTE 
YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHAYT 
IMAGGWVSCF LLALLPMVGI SSYAKVSICL PMDTDTPLAL AYIALVLLLN VVAFVIVCSC 
YVKIYITVRN PQYNPRDKDT KIAKRMAVLI FTDFMCMAPI SFYALSALMN KPLITVTNSG 
VLLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGLCK HQAQAYQAQR VCPNNNTGIQ 
IQKIPQDTRQ SLPNVQDTYE PLGSSHLTPK LQGRISEEYT QTAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.