Arrb1 | ENSRNOG00000030404 | NCBI 25387

Details for: Arrb1

Gene ID: 25387

Symbol: Arrb1

Ensembl ID: ENSRNOG00000030404

Description: arrestin, beta 1

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Deubiquitination
(R-RNO-5688426)
G alpha (s) signalling events
(R-RNO-418555)
Golgi associated vesicle biogenesis
(R-RNO-432722)
Gpcr downstream signalling
(R-RNO-388396)
Hemostasis
(R-RNO-109582)
Lysosome vesicle biogenesis
(R-RNO-432720)
Map2k and mapk activation
(R-RNO-5674135)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Post-translational protein modification
(R-RNO-597592)
Raf/map kinase cascade
(R-RNO-5673001)
Signaling by gpcr
(R-RNO-372790)
Thrombin signalling through proteinase activated receptors (pars)
(R-RNO-456926)
Trans-golgi network vesicle budding
(R-RNO-199992)
Ub-specific processing proteases
(R-RNO-5689880)
Vesicle-mediated transport
(R-RNO-5653656)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Alpha-1a adrenergic receptor binding
(GO:0031691)
Alpha-1b adrenergic receptor binding
(GO:0031692)
Angiotensin receptor binding
(GO:0031701)
Ap-2 adaptor complex binding
(GO:0035612)
Arrestin family protein binding
(GO:1990763)
Chromatin
(GO:0000785)
Clathrin-coated pit
(GO:0005905)
Clathrin adaptor activity
(GO:0035615)
Clathrin binding
(GO:0030276)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endosome
(GO:0005768)
Enzyme binding
(GO:0019899)
Follicle-stimulating hormone receptor binding
(GO:0031762)
Follicle-stimulating hormone signaling pathway
(GO:0042699)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor internalization
(GO:0002031)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activator activity
(GO:0005096)
Histone acetyltransferase activity
(GO:0004402)
Insulin-like growth factor receptor binding
(GO:0005159)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of signal transduction
(GO:0009968)
Nuclear estrogen receptor binding
(GO:0030331)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphoprotein binding
(GO:0051219)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein phosphorylated amino acid binding
(GO:0045309)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to morphine
(GO:0043278)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of touch
(GO:0050975)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Stress fiber assembly
(GO:0043149)
Transcription coactivator activity
(GO:0003713)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin protein ligase binding
(GO:0031625)
V2 vasopressin receptor binding
(GO:0031896)
Visual perception
(GO:0007601)

Other Information

Proteins

Beta-arrestin-1
A0A8I6G7K6_RAT

Genular Protein ID: 144789077

Symbol: ARRB1_RAT

Name: Beta-arrestin-1

UniProtKB Accession Codes:

P29066

Database IDs:

Citations:

PubMed ID: 1517224

Title: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

PubMed ID: 1517224

DOI: 10.1016/s0021-9258(19)37125-x

PubMed ID: 8553074

Title: Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.

PubMed ID: 8553074

DOI: 10.1126/science.271.5247.363

PubMed ID: 9388255

Title: Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.

PubMed ID: 9388255

DOI: 10.1074/jbc.272.49.31051

PubMed ID: 9822622

Title: beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.

PubMed ID: 9822622

DOI: 10.1074/jbc.273.48.31640

PubMed ID: 10212203

Title: Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin.

PubMed ID: 10212203

DOI: 10.1074/jbc.274.18.12333

PubMed ID: 10347185

Title: beta-arrestins regulate interleukin-8-induced CXCR1 internalization.

PubMed ID: 10347185

DOI: 10.1074/jbc.274.23.16287

PubMed ID: 10097102

Title: The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.

PubMed ID: 10097102

DOI: 10.1073/pnas.96.7.3712

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 10753943

Title: beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.

PubMed ID: 10753943

DOI: 10.1074/jbc.275.15.11312

PubMed ID: 10747877

Title: Regulation and intracellular trafficking pathways of the endothelin receptors.

PubMed ID: 10747877

DOI: 10.1074/jbc.m000142200

PubMed ID: 10770944

Title: The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.

PubMed ID: 10770944

DOI: 10.1074/jbc.m002581200

PubMed ID: 10725339

Title: beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

PubMed ID: 10725339

DOI: 10.1083/jcb.148.6.1267

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 10995467

Title: The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.

PubMed ID: 10995467

DOI: 10.1073/pnas.190276697

PubMed ID: 11742073

Title: beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

PubMed ID: 11742073

DOI: 10.1073/pnas.211572798

PubMed ID: 11579203

Title: Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization.

PubMed ID: 11579203

DOI: 10.1210/mend.15.10.0714

PubMed ID: 11777907

Title: beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin.

PubMed ID: 11777907

DOI: 10.1074/jbc.m108490200

PubMed ID: 11777902

Title: beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.

PubMed ID: 11777902

DOI: 10.1074/jbc.m106457200

PubMed ID: 11901145

Title: alpha-Thrombin induces rapid and sustained Akt phosphorylation by beta-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression.

PubMed ID: 11901145

DOI: 10.1074/jbc.m108995200

PubMed ID: 12399592

Title: Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.

PubMed ID: 12399592

DOI: 10.1126/science.1074683

PubMed ID: 12519791

Title: Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases.

PubMed ID: 12519791

DOI: 10.1074/jbc.m203992200

PubMed ID: 12821670

Title: A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis.

PubMed ID: 12821670

DOI: 10.1074/jbc.m300573200

PubMed ID: 15173580

Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 15173580

DOI: 10.1073/pnas.0402851101

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 16641100

Title: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.

PubMed ID: 16641100

DOI: 10.1073/pnas.0600895103

PubMed ID: 17594911

Title: The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling.

PubMed ID: 17594911

DOI: 10.1016/j.cellsig.2007.05.006

PubMed ID: 18006496

Title: Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.

PubMed ID: 18006496

DOI: 10.1074/jbc.m706892200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

Sequence Information:

Length: 418
Mass: 47020
Checksum: 0A3C07D71B7ABC55
Sequence:

MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA 
FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP 
PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP 
QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD 
ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL 
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP 
PHREVPESET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKDEEDDGT GSPHLNNR

Genular Protein ID: 3243824711

Symbol: A0A8I6G7K6_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8I6G7K6

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 463
Mass: 52327
Checksum: 3F3F93C150708602
Sequence:

MPWTSCRCPL LLHNSVTWVH HETGRSRVQA QPGLPKETVV NKETNEQDEG VAPRRSHGLR 
VFKKASPNGK LTVYLGKRDF VDHIDLVDPV DGVVLVDPEY LKERRVYVTL TCAFRYGRED 
LDVLGLTFRK DLFVANVQSF PPAPEDKKPL TRLQERLIKK LGEHAYPFTF EIPPNLPCSV 
TLQPGPEDTG KACGVDYEVK AFCAENLEEK IHKRNSVRLV IRKVQYAPER PGPQPTAETT 
RQFLMSDKPL HLEASLDKEI YYHGEPISVN VHVTNNTNKT VKKIKISVRQ YADICLFNTA 
QYKCPVAMEE ADDTVAPSST FCKVYTLTPF LANNREKRGL ALDGKLKHED TNLASSTLLR 
EGANREILGI IVSYKVKVKL VVSRGGDVAV ELPFTLMHPK PKEEPPHREV PESETPVDTN 
LIELDTNDDD IVFEDFARQR LKGMKDDKDE EDDGTGSPHL NNR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arrb1

Associated with

Other Information

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. PubMed ID: 1517224

Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. PubMed ID: 8553074

Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. PubMed ID: 9388255

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. PubMed ID: 9822622

Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin. PubMed ID: 10212203

beta-arrestins regulate interleukin-8-induced CXCR1 internalization. PubMed ID: 10347185

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. PubMed ID: 10097102

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. PubMed ID: 9924018

beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. PubMed ID: 10753943

Regulation and intracellular trafficking pathways of the endothelin receptors. PubMed ID: 10747877

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. PubMed ID: 10770944

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. PubMed ID: 10725339

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. PubMed ID: 10973280

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. PubMed ID: 10995467

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. PubMed ID: 11742073

Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. PubMed ID: 11579203

beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin. PubMed ID: 11777907

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. PubMed ID: 11777902

alpha-Thrombin induces rapid and sustained Akt phosphorylation by beta-arrestin1-dependent and -independent mechanisms, and only the sustained Akt phosphorylation is essential for G1 phase progression. PubMed ID: 11901145

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. PubMed ID: 12399592

Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. PubMed ID: 12519791

A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. PubMed ID: 12821670

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. PubMed ID: 15173580

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. PubMed ID: 15878855

Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. PubMed ID: 16641100

The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling. PubMed ID: 17594911

Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription. PubMed ID: 18006496

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822