Arrb2 | ENSRNOG00000019308 | NCBI 25388

Details for: Arrb2

Gene ID: 25388

Symbol: Arrb2

Ensembl ID: ENSRNOG00000019308

Description: arrestin, beta 2

Associated with

Beta-catenin independent wnt signaling
(R-RNO-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Deubiquitination
(R-RNO-5688426)
G alpha (s) signalling events
(R-RNO-418555)
Gpcr downstream signalling
(R-RNO-388396)
Hemostasis
(R-RNO-109582)
Map2k and mapk activation
(R-RNO-5674135)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Pcp/ce pathway
(R-RNO-4086400)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Post-translational protein modification
(R-RNO-597592)
Raf/map kinase cascade
(R-RNO-5673001)
Signaling by gpcr
(R-RNO-372790)
Signaling by wnt
(R-RNO-195721)
Thrombin signalling through proteinase activated receptors (pars)
(R-RNO-456926)
Ub-specific processing proteases
(R-RNO-5689880)
Vesicle-mediated transport
(R-RNO-5653656)
Wnt5a-dependent internalization of fzd4
(R-RNO-5099900)
14-3-3 protein binding
(GO:0071889)
Adult walking behavior
(GO:0007628)
Alpha-1a adrenergic receptor binding
(GO:0031691)
Alpha-1b adrenergic receptor binding
(GO:0031692)
Angiotensin receptor binding
(GO:0031701)
Arrestin family protein binding
(GO:1990763)
Cell chemotaxis
(GO:0060326)
Circadian rhythm
(GO:0007623)
D1 dopamine receptor binding
(GO:0031748)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Endocytosis
(GO:0006897)
Enzyme binding
(GO:0019899)
Follicle-stimulating hormone receptor binding
(GO:0031762)
Follicle-stimulating hormone signaling pathway
(GO:0042699)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor internalization
(GO:0002031)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Mitogen-activated protein kinase binding
(GO:0051019)
Modulation of chemical synaptic transmission
(GO:0050804)
Molecular adaptor activity
(GO:0060090)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of natural killer cell mediated cytotoxicity
(GO:0045953)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of opioid receptor signaling pathway
(GO:2000475)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleus
(GO:0005634)
Platelet activating factor receptor binding
(GO:0031859)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cardiac muscle cell differentiation
(GO:2000727)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of epithelial cell apoptotic process
(GO:1904037)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of opioid receptor signaling pathway
(GO:2000476)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of synaptic transmission, dopaminergic
(GO:0032226)
Postsynaptic signal transduction
(GO:0098926)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase b binding
(GO:0043422)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Receptor internalization
(GO:0031623)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of protein phosphorylation
(GO:0001932)
Response to morphine
(GO:0043278)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Transcription by rna polymerase ii
(GO:0006366)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type 1 angiotensin receptor binding
(GO:0031702)
Type 2a serotonin receptor binding
(GO:0031826)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Beta-arrestin-2

Genular Protein ID: 1263244569

Symbol: ARRB2_RAT

Name: Beta-arrestin-2

UniProtKB Accession Codes:

P29067

Database IDs:

Citations:

PubMed ID: 1517224

Title: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

PubMed ID: 1517224

DOI: 10.1016/s0021-9258(19)37125-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8308033

Title: Cone arrestin identified by targeting expression of a functional family.

PubMed ID: 8308033

DOI: 10.1016/s0021-9258(17)41820-5

PubMed ID: 9767391

Title: Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues.

PubMed ID: 9767391

DOI: 10.1046/j.1460-9568.1998.t01-1-00271.x

PubMed ID: 9822622

Title: beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.

PubMed ID: 9822622

DOI: 10.1074/jbc.273.48.31640

PubMed ID: 10097102

Title: The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.

PubMed ID: 10097102

DOI: 10.1073/pnas.96.7.3712

PubMed ID: 10753943

Title: beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.

PubMed ID: 10753943

DOI: 10.1074/jbc.275.15.11312

PubMed ID: 10747877

Title: Regulation and intracellular trafficking pathways of the endothelin receptors.

PubMed ID: 10747877

DOI: 10.1074/jbc.m000142200

PubMed ID: 10770944

Title: The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.

PubMed ID: 10770944

DOI: 10.1074/jbc.m002581200

PubMed ID: 10852825

Title: Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors.

PubMed ID: 10852825

DOI: 10.1242/jcs.113.13.2463

PubMed ID: 11090355

Title: Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.

PubMed ID: 11090355

DOI: 10.1126/science.290.5496.1574

PubMed ID: 11448957

Title: Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.

PubMed ID: 11448957

DOI: 10.1074/jbc.m102782200

PubMed ID: 11226259

Title: Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

PubMed ID: 11226259

DOI: 10.1073/pnas.041604898

PubMed ID: 11588219

Title: Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.

PubMed ID: 11588219

DOI: 10.1126/science.1063866

PubMed ID: 12186555

Title: Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.

PubMed ID: 12186555

DOI: 10.1021/bi025705n

PubMed ID: 11777907

Title: beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin.

PubMed ID: 11777907

DOI: 10.1074/jbc.m108490200

PubMed ID: 11777902

Title: beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.

PubMed ID: 11777902

DOI: 10.1074/jbc.m106457200

PubMed ID: 12464600

Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.

PubMed ID: 12464600

DOI: 10.1074/jbc.m210120200

PubMed ID: 12944399

Title: The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.

PubMed ID: 12944399

DOI: 10.1074/jbc.m309450200

PubMed ID: 14500724

Title: The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.

PubMed ID: 14500724

DOI: 10.1074/jbc.m303772200

PubMed ID: 15173580

Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 15173580

DOI: 10.1073/pnas.0402851101

PubMed ID: 15618519

Title: Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

PubMed ID: 15618519

DOI: 10.1126/science.1104135

PubMed ID: 16051150

Title: An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.

PubMed ID: 16051150

DOI: 10.1016/j.cell.2005.05.012

PubMed ID: 15699045

Title: Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.

PubMed ID: 15699045

DOI: 10.1074/jbc.m412418200

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 15738310

Title: Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

PubMed ID: 15738310

DOI: 10.1124/mol.104.009423

PubMed ID: 17666399

Title: Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.

PubMed ID: 17666399

DOI: 10.1074/jbc.m700852200

PubMed ID: 18006496

Title: Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription.

PubMed ID: 18006496

DOI: 10.1074/jbc.m706892200

PubMed ID: 18408005

Title: The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus.

PubMed ID: 18408005

DOI: 10.1074/jbc.m710006200

PubMed ID: 19055777

Title: Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors.

PubMed ID: 19055777

DOI: 10.1186/1750-2187-3-20

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

Sequence Information:

Length: 410
Mass: 46340
Checksum: 0DFA6A897C2B86BA
Sequence:

MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 
AFRYGREDLD VLGLSFRKDL FIATYQAFPP MPNPPRPPTR LQDRLLKKLG QHAHPFFFTI 
PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSIEEKSH KRNSVRLIIR KVQFAPETPG 
PQPSAETTRH FLMSDRRSLH LEASLDKELY YHGEPLNVNV HVTNNSAKTV KKIRVSVRQY 
ADICLFSTAQ YKCPVAQLEQ DDQVSPSSTF CKVYTITPLL SDNREKRGLA LDGQLKHEDT 
NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHITLPRPQ 
SAPREIDIPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDCDDQFC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Arrb2

Associated with

Other Information

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. PubMed ID: 1517224

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cone arrestin identified by targeting expression of a functional family. PubMed ID: 8308033

Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues. PubMed ID: 9767391

beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. PubMed ID: 9822622

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. PubMed ID: 10097102

beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. PubMed ID: 10753943

Regulation and intracellular trafficking pathways of the endothelin receptors. PubMed ID: 10747877

The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits. PubMed ID: 10770944

Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors. PubMed ID: 10852825

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. PubMed ID: 11090355

Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization. PubMed ID: 11448957

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. PubMed ID: 11226259

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. PubMed ID: 11588219

Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. PubMed ID: 12186555

beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin. PubMed ID: 11777907

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. PubMed ID: 11777902

Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. PubMed ID: 12464600

The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. PubMed ID: 12944399

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. PubMed ID: 14500724

beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. PubMed ID: 15173580

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. PubMed ID: 15618519

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. PubMed ID: 16051150

Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. PubMed ID: 15699045

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. PubMed ID: 15878855

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. PubMed ID: 15738310

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. PubMed ID: 17666399

Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription. PubMed ID: 18006496

The beta-arrestin-2 scaffold protein promotes c-Jun N-terminal kinase-3 activation by binding to its nonconserved N terminus. PubMed ID: 18408005

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors. PubMed ID: 19055777

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940