Cyp1b1 | ENSRNOG00000040287 | NCBI 25426

Details for: Cyp1b1

Gene ID: 25426

Symbol: Cyp1b1

Ensembl ID: ENSRNOG00000040287

Description: cytochrome P450, family 1, subfamily b, polypeptide 1

Associated with

Arachidonic acid metabolism
(R-RNO-2142753)
Biological oxidations
(R-RNO-211859)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Endogenous sterols
(R-RNO-211976)
Fatty acid metabolism
(R-RNO-8978868)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Phase i - functionalization of compounds
(R-RNO-211945)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (hete)
(R-RNO-2142816)
Synthesis of epoxy (eet) and dihydroxyeicosatrienoic acids (dhet)
(R-RNO-2142670)
Adrenal gland development
(GO:0030325)
Angiogenesis
(GO:0001525)
Arachidonic acid metabolic process
(GO:0019369)
Aromatase activity
(GO:0070330)
Benzene-containing compound metabolic process
(GO:0042537)
Blood vessel endothelial cell migration
(GO:0043534)
Blood vessel morphogenesis
(GO:0048514)
Cell adhesion
(GO:0007155)
Cellular aromatic compound metabolic process
(GO:0006725)
Cellular response to camp
(GO:0071320)
Cellular response to cortisol stimulus
(GO:0071387)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to luteinizing hormone stimulus
(GO:0071373)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to progesterone stimulus
(GO:0071393)
Cellular response to toxic substance
(GO:0097237)
Cellular response to tumor necrosis factor
(GO:0071356)
Collagen fibril organization
(GO:0030199)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Dna modification
(GO:0006304)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endothelial cell-cell adhesion
(GO:0071603)
Endothelial cell migration
(GO:0043542)
Estrogen 16-alpha-hydroxylase activity
(GO:0101020)
Estrogen metabolic process
(GO:0008210)
Estrous cycle
(GO:0044849)
Ganglion development
(GO:0061548)
Heme binding
(GO:0020037)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Iron ion binding
(GO:0005506)
Male gonad development
(GO:0008584)
Membrane
(GO:0016020)
Membrane lipid catabolic process
(GO:0046466)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Negative regulation of cell adhesion mediated by integrin
(GO:0033629)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Nitric oxide biosynthetic process
(GO:0006809)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(GO:0016705)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
(GO:0016712)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of translation
(GO:0045727)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to 3-methylcholanthrene
(GO:1904681)
Response to arsenic-containing substance
(GO:0046685)
Response to dexamethasone
(GO:0071548)
Response to estradiol
(GO:0032355)
Response to follicle-stimulating hormone
(GO:0032354)
Response to indole-3-methanol
(GO:0071680)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to steroid hormone
(GO:0048545)
Response to toxic substance
(GO:0009636)
Retinal blood vessel morphogenesis
(GO:0061304)
Retinal metabolic process
(GO:0042574)
Retina vasculature development in camera-type eye
(GO:0061298)
Retinol metabolic process
(GO:0042572)
Steroid metabolic process
(GO:0008202)
Toxin metabolic process
(GO:0009404)
Trabecular meshwork development
(GO:0002930)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

Cytochrome P450 1B1

Genular Protein ID: 603701264

Symbol: CP1B1_RAT

Name: Cytochrome P450 1B1

UniProtKB Accession Codes:

Q64678

Database IDs:

Citations:

PubMed ID: 7744798

Title: Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation.

PubMed ID: 7744798

DOI: 10.1074/jbc.270.19.11595

PubMed ID: 7788849

Title: Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals.

PubMed ID: 7788849

DOI: 10.1093/carcin/16.6.1319

PubMed ID: 20972997

Title: Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards.

PubMed ID: 20972997

DOI: 10.1002/rcm.4760

PubMed ID: 21867498

Title: Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.

PubMed ID: 21867498

DOI: 10.1186/2045-8118-8-23

PubMed ID: 21785971

Title: Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.

PubMed ID: 21785971

DOI: 10.1007/s11010-011-0994-z

PubMed ID: 23026235

Title: The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polkappa), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver.

PubMed ID: 23026235

DOI: 10.1016/j.etap.2012.09.004

PubMed ID: 23821647

Title: Specificity determinants of CYP1B1 estradiol hydroxylation.

PubMed ID: 23821647

DOI: 10.1124/mol.113.087700

Sequence Information:

Length: 543
Mass: 60557
Checksum: 8D144B0000D5F095
Sequence:

MATSLSADSP QQLSSLSTQQ TILLLLVSVL AIVHLGQWLL RQWRRKPWSS PPGPFPWPLI 
GNAASVGRAS HLYFARLARR YGDVFQIRLG SCPVVVLNGE SAIHQALVQQ GGVFADRPPF 
ASFRVVSGGR SLAFGHYSER WKERRRAAYG TMRAFSTRHP RSRGLLEGHA LGEARELVAV 
LVRRCAGGAC LDPTQPIIVA VANVMSAVCF GCRYNHDDAE FLELLSHNEE FGRTVGAGSL 
VDVMPWLQLF PNPVRTIFRE FEQINRNFSN FVLDKFLRHR ESLVPGAAPR DMMDAFILSA 
EKKATGDPGD SPSGLDLEDV PATITDIFGA SQDTLSTALL WLLILFTRYP DVQARVQAEL 
DQVVGRDRLP CMSDQPNLPY VMAFLYESMR FTSFLPVTLP HATTANTFVL GYYIPKNTVV 
FVNQWSVNHD PAKWSNPEDF DPARFLDKDG FINKALASSV MIFSVGKRRC IGEELSKTLL 
FLFISILAHQ CNFKANQNEP SNMSFSYGLS IKPKSFKIHV SLRESMKLLD SAVEKLQAEE 
ACQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp1b1

Associated with

Other Information

Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. PubMed ID: 7744798

Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. PubMed ID: 7788849

Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. PubMed ID: 20972997

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. PubMed ID: 21867498

Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor. PubMed ID: 21785971

The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polkappa), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver. PubMed ID: 23026235

Specificity determinants of CYP1B1 estradiol hydroxylation. PubMed ID: 23821647