Details for: Cyp51

Gene ID: 25427

Symbol: Cyp51

Ensembl ID: ENSRNOG00000007234

Description: cytochrome P450, family 51

Associated with

Other Information

Genular Protein ID: 3476509068

Symbol: CP51A_RAT

Name: CYPLI

UniProtKB Accession Codes:

Q64654 Q64549

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 CDD 1 CTD 1 ChEBI 93 ChEMBL 1 DrugCentral 1 EC 2 EMBL 4 Ensembl 4 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 2 RefSeq 1 Rhea 48 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 eggNOG 1 jPOST 1

Citations:

PubMed ID: 8024575

Title: Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver.

PubMed ID: 8024575

DOI: 10.1006/bbrc.1994.1848

PubMed ID: 9498553

Title: Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.

PubMed ID: 9498553

DOI: 10.1093/oxfordjournals.jbchem.a021869

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7665087

Title: Cloning and functional expression of the cDNA encoding rat lanosterol 14-alpha demethylase.

PubMed ID: 7665087

DOI: 10.1016/0378-1119(95)00211-n

PubMed ID: 3782148

Title: Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process.

PubMed ID: 3782148

DOI: 10.1016/s0021-9258(19)75980-8

PubMed ID: 1872829

Title: Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol.

PubMed ID: 1872829

DOI: 10.1016/0006-291x(91)91000-3

PubMed ID: 8797093

Title: Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species.

PubMed ID: 8797093

DOI: 10.1093/oxfordjournals.jbchem.a021331

PubMed ID: 10544287

Title: Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli.

PubMed ID: 10544287

DOI: 10.1093/oxfordjournals.jbchem.a022536

PubMed ID: 11328599

Title: The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450).

PubMed ID: 11328599

DOI: 10.1093/oxfordjournals.jbchem.a002917

Sequence Information:

  • Length: 503
  • Mass: 56707
  • Checksum: 33D8F345FFE9CF21
  • Sequence:
    • MVLLGLLQSG GSVLGQAMEQ VTGGNLLSTL LIACAFTLSL VYLFRLAVGH MVQLPAGAKS 
PPYIYSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS 
KNEDLNAEEV YGRLTTPVFG KGVAYDVPNA VFLEQKKILK SGLNIAHFKQ YVSIIEKEAK 
EYFKSWGESG ERNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL 
LPGWLPLPSF RRRDRAHREI KNIFYKAIQK RRLSKEPAED ILQTLLDSTY KDGRPLTDDE 
IAGMLIGLLL AGQHTSSTTS AWMGFFLARD KPLQDKCYLE QKTVCGEDLP PLTYEQLKDL 
NLLDRCIKET LRLRPPIMTM MRMAKTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWVERLD 
FNPDRYLQDN PASGEKFAYV PFGAGRHRCI GENFAYVQIK TIWSTMLRLY EFDLINGYFP 
SVNYTTMIHT PENPVIRYKR RSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.