Cyp7a1 | ENSRNOG00000009488 | NCBI 25428

Details for: Cyp7a1

Gene ID: 25428

Symbol: Cyp7a1

Ensembl ID: ENSRNOG00000009488

Description: cytochrome P450 family 7 subfamily A member 1

Associated with

Bile acid and bile salt metabolism
(R-RNO-194068)
Biological oxidations
(R-RNO-211859)
Cytochrome p450 - arranged by substrate type
(R-RNO-211897)
Endogenous sterols
(R-RNO-211976)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of steroids
(R-RNO-8957322)
Phase i - functionalization of compounds
(R-RNO-211945)
Synthesis of bile acids and bile salts
(R-RNO-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-RNO-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-RNO-193807)
24-hydroxycholesterol 7alpha-hydroxylase activity
(GO:0033782)
Bile acid and bile salt transport
(GO:0015721)
Bile acid biosynthetic process
(GO:0006699)
Bile acid signaling pathway
(GO:0038183)
Cellular response to cholesterol
(GO:0071397)
Cellular response to glucose stimulus
(GO:0071333)
Cholesterol 7-alpha-monooxygenase activity
(GO:0008123)
Cholesterol catabolic process
(GO:0006707)
Cholesterol homeostasis
(GO:0042632)
Endoplasmic reticulum membrane
(GO:0005789)
Heme binding
(GO:0020037)
Intracellular membrane-bounded organelle
(GO:0043231)
Iron ion binding
(GO:0005506)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Positive regulation of cholesterol biosynthetic process
(GO:0045542)
Regulation of bile acid biosynthetic process
(GO:0070857)
Response to ethanol
(GO:0045471)
Response to organic cyclic compound
(GO:0014070)

Other Information

Proteins

CYPVII

Genular Protein ID: 2057879363

Symbol: CP7A1_RAT

Name: CYPVII

UniProtKB Accession Codes:

P18125 P51543

Database IDs:

Citations:

PubMed ID: 1694852

Title: Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.

PubMed ID: 1694852

DOI: 10.1016/s0021-9258(19)38501-1

PubMed ID: 2335522

Title: Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

PubMed ID: 2335522

DOI: 10.1016/s0021-9258(19)39056-8

PubMed ID: 2806567

Title: Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression.

PubMed ID: 2806567

DOI: 10.1016/0014-5793(89)81795-8

PubMed ID: 1693613

Title: Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.

PubMed ID: 1693613

DOI: 10.1016/s0021-9258(19)38775-7

PubMed ID: 2007596

Title: Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis.

PubMed ID: 2007596

DOI: 10.1016/s0021-9258(18)38141-9

PubMed ID: 8021257

Title: Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.

PubMed ID: 8021257

DOI: 10.1016/s0021-9258(17)32469-9

PubMed ID: 2261433

Title: Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase.

PubMed ID: 2261433

DOI: 10.1021/bi00486a001

PubMed ID: 1420318

Title: Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.

PubMed ID: 1420318

DOI: 10.1016/0167-4781(92)90175-y

PubMed ID: 11278771

Title: Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway.

PubMed ID: 11278771

DOI: 10.1074/jbc.m010878200

Sequence Information:

Length: 503
Mass: 56883
Checksum: EA825AA6E74BF5F6
Sequence:

MMTISLIWGI AVLVSCCIWF IVGIRRRKAG EPPLENGLIP YLGCALKFGS NPLEFLRANQ 
RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPNDGN 
TTENINNTFT KTLQGDALCS LSEAMMQNLQ SVMRPPGLPK SKSNAWVTEG MYAFCYRVMF 
EAGYLTLFGR DISKTDTQKA LILNNLDNFK QFDQVFPALV AGLPIHLFKT AHKAREKLAE 
GLKHKNLCVR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL AILWASQANT IPATFWSLFQ 
MIRSPEAMKA ASEEVSGALQ SAGQELSSGG SAIYLDQVQL NDLPVLDSII KEALRLSSAS 
LNIRTAKEDF TLHLEDGSYN IRKDDMIALY PQLMHLDPEI YPDPLTFKYD RYLDESGKAK 
TTFYSNGNKL KCFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSCFELEFV ESQVKCPPLD 
QSRAGLGILP PLHDIEFKYK LKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cyp7a1

Associated with

Other Information

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. PubMed ID: 1694852

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. PubMed ID: 2335522

Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression. PubMed ID: 2806567

Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm. PubMed ID: 1693613

Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis. PubMed ID: 2007596

Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter. PubMed ID: 8021257

Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase. PubMed ID: 2261433

Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene. PubMed ID: 1420318

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. PubMed ID: 11278771