Details for: Gdnf

Gene ID: 25453

Symbol: Gdnf

Ensembl ID: ENSRNOG00000012819

Description: glial cell derived neurotrophic factor

Associated with

  • Branching involved in ureteric bud morphogenesis
    (GO:0001658)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Commissural neuron axon guidance
    (GO:0071679)
  • Dorsal spinal cord development
    (GO:0021516)
  • Embryonic organ development
    (GO:0048568)
  • Enteric nervous system development
    (GO:0048484)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glial cell-derived neurotrophic factor receptor binding
    (GO:0030116)
  • Golgi apparatus
    (GO:0005794)
  • Growth factor activity
    (GO:0008083)
  • Male gonad development
    (GO:0008584)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Metanephros development
    (GO:0001656)
  • Midbrain development
    (GO:0030901)
  • Mrna stabilization
    (GO:0048255)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Nervous system development
    (GO:0007399)
  • Neural crest cell migration
    (GO:0001755)
  • Neuron differentiation
    (GO:0030182)
  • Neuron projection development
    (GO:0031175)
  • Organ induction
    (GO:0001759)
  • Peripheral nervous system development
    (GO:0007422)
  • Peristalsis
    (GO:0030432)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0072108)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of ureteric bud formation
    (GO:0072107)
  • Postganglionic parasympathetic fiber development
    (GO:0021784)
  • Postsynaptic membrane organization
    (GO:0001941)
  • Protein homodimerization activity
    (GO:0042803)
  • Receptor complex
    (GO:0043235)
  • Receptor ligand activity
    (GO:0048018)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of dopamine uptake involved in synaptic transmission
    (GO:0051584)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of morphogenesis of a branching structure
    (GO:0060688)
  • Regulation of semaphorin-plexin signaling pathway
    (GO:2001260)
  • Regulation of ureteric bud formation
    (GO:0072106)
  • Retina development in camera-type eye
    (GO:0060041)
  • Signal transduction
    (GO:0007165)
  • Sympathetic nervous system development
    (GO:0048485)
  • Ureteric bud development
    (GO:0001657)
  • Ureteric bud formation
    (GO:0060676)

Other Information

Genular Protein ID: 4209107006

Symbol: GDNF_RAT

Name: Glial cell line-derived neurotrophic factor

UniProtKB Accession Codes:

Q07731 Q63214 Q64062 Q64063 Q8R485 Q9QX94 Q9QX95 Q9QXJ7 Q9QXJ8 Q9QXJ9

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 CDD 1 CTD 1 DisProt 1 EMBL 10 EvolutionaryTrace 1 GO 48 Gene3D 1 GlyCosmos 1 GlyGen 1 InParanoid 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 1 eggNOG 1

Citations:

PubMed ID: 8493557

Title: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.

PubMed ID: 8493557

DOI: 10.1126/science.8493557

PubMed ID: 7895811

Title: cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle.

PubMed ID: 7895811

DOI: 10.1016/0014-4886(95)90006-3

PubMed ID: 10828539

Title: Anterograde axonal transport of glial cell line-derived neurotrophic factor and its receptors in rat hypoglossal nerve.

PubMed ID: 10828539

DOI: 10.1016/s0306-4522(00)00079-8

PubMed ID: 7696586

Title: GDNF is expressed in two forms in many tissues outside the CNS.

PubMed ID: 7696586

DOI: 10.1097/00001756-199412000-00020

PubMed ID: 11930164

Title: Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells.

PubMed ID: 11930164

DOI: 10.1097/00001756-200203250-00023

PubMed ID: 7867768

Title: Multiple astrocyte transcripts encode nigral trophic factors in rat and human.

PubMed ID: 7867768

DOI: 10.1006/exnr.1994.1218

PubMed ID: 21994944

Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.

PubMed ID: 21994944

DOI: 10.1074/jbc.m111.246413

PubMed ID: 9187648

Title: X-ray structure of glial cell-derived neurotrophic factor at 1.9-A resolution and implications for receptor binding.

PubMed ID: 9187648

DOI: 10.1038/nsb0697-435

Sequence Information:

  • Length: 211
  • Mass: 23619
  • Checksum: AE06C646682895A5
  • Sequence:
    • MKLWDVVAVC LVLLHTASAF PLPAGKRLLE APAEDHSLGH RRVPFALTSD SNMPEDYPDQ 
FDDVMDFIQA TIKRLKRSPD KQAAALPRRE RNRQAAAASP ENSRGKGRRG QRGKNRGCVL 
TAIHLNVTDL GLGYETKEEL IFRYCSGSCE AAETMYDKIL KNLSRSRRLT SDKVGQACCR 
PVAFDDDLSF LDDSLVYHIL RKHSAKRCGC I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.