Irs1 | ENSRNOG00000014597 | NCBI 25467

Details for: Irs1

Gene ID: 25467

Symbol: Irs1

Ensembl ID: ENSRNOG00000014597

Description: insulin receptor substrate 1

Associated with

Caveola
(GO:0005901)
Cell migration
(GO:0016477)
Cellular response to angiotensin
(GO:1904385)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Cellular response to fatty acid
(GO:0071398)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to radiation
(GO:0071478)
Ciliary basal body
(GO:0036064)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epithelial cell migration
(GO:0010631)
Insulin-like growth factor receptor binding
(GO:0005159)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor binding
(GO:0005158)
Insulin receptor complex
(GO:0005899)
Insulin receptor signaling pathway
(GO:0008286)
Insulin secretion
(GO:0030073)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid catabolic process
(GO:0016042)
Mammary gland development
(GO:0030879)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of somatostatin secretion
(GO:0090275)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase activator activity
(GO:0141038)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of fatty acid beta-oxidation
(GO:0032000)
Positive regulation of glucagon secretion
(GO:0070094)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of glucose metabolic process
(GO:0010907)
Positive regulation of glycogen biosynthetic process
(GO:0045725)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Protein localization to nucleus
(GO:0034504)
Regulation of gene expression
(GO:0010468)
Response to activity
(GO:0014823)
Response to caffeine
(GO:0031000)
Response to insulin
(GO:0032868)
Sh2 domain binding
(GO:0042169)
Signaling receptor complex adaptor activity
(GO:0030159)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)

Other Information

Proteins

Insulin receptor substrate 1

Genular Protein ID: 3712101935

Symbol: IRS1_RAT

Name: Insulin receptor substrate 1

UniProtKB Accession Codes:

P35570

Database IDs:

Citations:

PubMed ID: 1648180

Title: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.

PubMed ID: 1648180

DOI: 10.1038/352073a0

PubMed ID: 2022647

Title: Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.

PubMed ID: 2022647

DOI: 10.1016/s0021-9258(18)92976-5

PubMed ID: 1380456

Title: Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.

PubMed ID: 1380456

DOI: 10.1002/j.1460-2075.1992.tb05426.x

PubMed ID: 8491186

Title: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

PubMed ID: 8491186

DOI: 10.1002/j.1460-2075.1993.tb05842.x

PubMed ID: 7504175

Title: Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.

PubMed ID: 7504175

DOI: 10.1128/mcb.13.12.7418-7428.1993

PubMed ID: 8349691

Title: Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.

PubMed ID: 8349691

DOI: 10.1016/s0021-9258(17)46824-4

PubMed ID: 11018022

Title: Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.

PubMed ID: 11018022

DOI: 10.1074/jbc.c000611200

PubMed ID: 11606564

Title: Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.

PubMed ID: 11606564

DOI: 10.1074/jbc.m101521200

PubMed ID: 12006586

Title: In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.

PubMed ID: 12006586

DOI: 10.1074/jbc.m201494200

PubMed ID: 11739394

Title: Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

PubMed ID: 11739394

DOI: 10.1074/jbc.m110508200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 24187137

Title: Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver.

PubMed ID: 24187137

DOI: 10.1074/jbc.m113.500736

PubMed ID: 25586176

Title: Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes.

PubMed ID: 25586176

DOI: 10.1074/jbc.m114.624759

PubMed ID: 27739494

Title: A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes.

PubMed ID: 27739494

DOI: 10.1038/srep35438

Sequence Information:

Length: 1235
Mass: 131178
Checksum: A274BC7540CA85C5
Sequence:

MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH 
HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL 
CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV 
AQNMHETILE AMRAMSDEFR PRTKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT 
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL 
HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF 
ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LTAPNGHYIL 
SRGGNGHRYI PGATMGTSPA LTGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV 
VSIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDSS 
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM 
MSPSGSCSPD IGGGSCSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL 
LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR 
HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSVTHPHHH ALQPHLPRKV 
DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQQQQ QSSLHPPEPK SPGEYVNIEF 
GSGQPGYLAG PATSRSSPSV RCLPQLHPAP REETGSEEYM NMDLGPGRRA TWQESGGVEL 
GRVGPAPPGA ASICRPTRSV PNSRGDYMTM QIGCPRQSYV DTSPVAPVSY ADMRTGIAAE 
KVSLPRTTGA APPPSSTASA SASVTPQGAA EQAAHSSLLG GPQGPGGMSA FTRVNLSPNH 
NQSAKVIRAD TQGCRRRHSS ETFSAPTRAA NTVSFGAGAA GGGSGGGSED VKRHSSASFE 
NVWLRPGDLG GASKESAPGC GAAGGLEKSL NYIDLDLVKD VKQHPQDCPS QQQSLPPPPP 
HQPLGSNEGS SPRRSSEDLS TYASINFQKQ PEDRQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Irs1

Associated with

Other Information

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. PubMed ID: 1648180

Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. PubMed ID: 2022647

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. PubMed ID: 1380456

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. PubMed ID: 8491186

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. PubMed ID: 7504175

Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. PubMed ID: 8349691

Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. PubMed ID: 11018022

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. PubMed ID: 11606564

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. PubMed ID: 12006586

Active Rho kinase (ROK-alpha) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. PubMed ID: 11739394

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. PubMed ID: 24187137

Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. PubMed ID: 25586176

A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. PubMed ID: 27739494