Details for: Kcna2
Associated with
Other Information
Genular Protein ID: 2897372322
Symbol: KCNA2_RAT
Name: Potassium voltage-gated channel subfamily A member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2722779
Title: Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family.
PubMed ID: 2722779
PubMed ID: 2555158
Title: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
PubMed ID: 2555158
PubMed ID: 1715584
Title: Cloning and expression of a rat cardiac delayed rectifier potassium channel.
PubMed ID: 1715584
PubMed ID: 8495559
Title: Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?
PubMed ID: 8495559
PubMed ID: 8355670
Title: Tityustoxin-K alpha, a structurally novel and highly potent K+ channel peptide toxin, interacts with the alpha-dendrotoxin binding site on the cloned Kv1.2 K+ channel.
PubMed ID: 8355670
PubMed ID: 8361540
Title: Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.
PubMed ID: 8361540
DOI: 10.1038/365072a0
PubMed ID: 7477295
Title: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.
PubMed ID: 7477295
DOI: 10.1038/378085a0
PubMed ID: 7544443
Title: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
PubMed ID: 7544443
DOI: 10.1038/376737a0
PubMed ID: 9635436
Title: The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.
PubMed ID: 9635436
PubMed ID: 10624965
Title: Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.
PubMed ID: 10624965
PubMed ID: 10896669
Title: Subunit composition determines Kv1 potassium channel surface expression.
PubMed ID: 10896669
PubMed ID: 11086297
Title: Subunit composition and novel localization of K+ channels in spinal cord.
PubMed ID: 11086297
DOI: 10.1002/1096-9861(20000101)429:1<166::aid-cne13>3.0.co;2-y
PubMed ID: 11739373
Title: Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking.
PubMed ID: 11739373
PubMed ID: 12151401
Title: Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.
PubMed ID: 12151401
PubMed ID: 12177193
Title: Two heteromeric Kv1 potassium channels differentially regulate action potential firing.
PubMed ID: 12177193
PubMed ID: 14713306
Title: Enhancement of ischemia-induced tyrosine phosphorylation of Kv1.2 by vascular endothelial growth factor via activation of phosphatidylinositol 3-kinase.
PubMed ID: 14713306
PubMed ID: 12777451
Title: Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion.
PubMed ID: 12777451
PubMed ID: 12632190
Title: Kv channel subunits that contribute to voltage-gated K+ current in renal vascular smooth muscle.
PubMed ID: 12632190
PubMed ID: 15151918
Title: Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes.
PubMed ID: 15151918
PubMed ID: 15618540
Title: Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter.
PubMed ID: 15618540
PubMed ID: 16210348
Title: Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells.
PubMed ID: 16210348
PubMed ID: 16306173
Title: Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels.
PubMed ID: 16306173
PubMed ID: 16770729
Title: Glycosylation and cell surface expression of Kv1.2 potassium channel are regulated by determinants in the pore region.
PubMed ID: 16770729
PubMed ID: 17324383
Title: The glycosylation state of Kv1.2 potassium channels affects trafficking, gating, and simulated action potentials.
PubMed ID: 17324383
PubMed ID: 17766348
Title: An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker.
PubMed ID: 17766348
PubMed ID: 17917103
Title: Ionic channel function in action potential generation: current perspective.
PubMed ID: 17917103
PubMed ID: 17869444
Title: Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus.
PubMed ID: 17869444
PubMed ID: 18003609
Title: Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP.
PubMed ID: 18003609
PubMed ID: 18638484
Title: Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers.
PubMed ID: 18638484
PubMed ID: 19713757
Title: The molecular basis for the actions of Kvbeta1.2 on the opening and closing of the Kv1.2 delayed rectifier channel.
PubMed ID: 19713757
PubMed ID: 19403695
Title: Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.
PubMed ID: 19403695
PubMed ID: 20805574
Title: Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium.
PubMed ID: 20805574
PubMed ID: 20089912
Title: ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.
PubMed ID: 20089912
PubMed ID: 21602278
Title: Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons.
PubMed ID: 21602278
PubMed ID: 21647367
Title: Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function.
PubMed ID: 21647367
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
DOI: 10.1038/ncomms1871
PubMed ID: 23725331
Title: Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their alpha subunits.
PubMed ID: 23725331
DOI: 10.1042/bj20130297
PubMed ID: 23318870
Title: A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.
PubMed ID: 23318870
PubMed ID: 24472174
Title: Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons.
PubMed ID: 24472174
PubMed ID: 25514171
Title: Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter.
PubMed ID: 25514171
PubMed ID: 11007484
Title: The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
PubMed ID: 11007484
PubMed ID: 16002581
Title: Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
PubMed ID: 16002581
PubMed ID: 16002579
Title: Voltage sensor of Kv1.2: structural basis of electromechanical coupling.
PubMed ID: 16002579
PubMed ID: 18004376
Title: Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
PubMed ID: 18004376
DOI: 10.1038/nature06265
PubMed ID: 20534430
Title: Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
PubMed ID: 20534430
PubMed ID: 20360102
Title: A gating charge transfer center in voltage sensors.
PubMed ID: 20360102
PubMed ID: 23705070
Title: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
PubMed ID: 23705070
DOI: 10.7554/elife.00594
Sequence Information:
- Length: 499
- Mass: 56701
- Checksum: A8FEA6F3F59AF42A
- Sequence:
MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA NCTLANTNYV NITKMLTDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.