Details for: Lgals9

Gene ID: 25476

Symbol: Lgals9

Ensembl ID: ENSRNOG00000012681

Description: galectin 9

Associated with

  • Carbohydrate binding
    (GO:0030246)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cellular response to virus
    (GO:0098586)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Disaccharide binding
    (GO:0048030)
  • Enzyme binding
    (GO:0019899)
  • Erk1 and erk2 cascade
    (GO:0070371)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Galactoside binding
    (GO:0016936)
  • Inflammatory response
    (GO:0006954)
  • Maintenance of protein location
    (GO:0045185)
  • Maternal process involved in female pregnancy
    (GO:0060135)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Monoatomic ion transport
    (GO:0006811)
  • Natural killer cell tolerance induction
    (GO:0002519)
  • Negative regulation of activated t cell proliferation
    (GO:0046007)
  • Negative regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000562)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of mast cell degranulation
    (GO:0043305)
  • Negative regulation of natural killer cell activation
    (GO:0032815)
  • Negative regulation of natural killer cell degranulation
    (GO:0043322)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Nucleus
    (GO:0005634)
  • P38mapk cascade
    (GO:0038066)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of activated t cell autonomous cell death
    (GO:0070241)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cd4-positive, alpha-beta t cell proliferation
    (GO:2000563)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation involved in immune response
    (GO:0032834)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of defense response to bacterium
    (GO:1900426)
  • Positive regulation of dendritic cell apoptotic process
    (GO:2000670)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of dendritic cell differentiation
    (GO:2001200)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-1 production
    (GO:0032732)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of regulatory t cell differentiation
    (GO:0045591)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cell
    (GO:2001190)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of viral entry into host cell
    (GO:0046598)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor clustering
    (GO:0043113)
  • Regulation of interleukin-4 production
    (GO:0032673)
  • Regulation of interleukin-5 production
    (GO:0032674)
  • Regulation of natural killer cell differentiation
    (GO:0032823)
  • Regulation of p38mapk cascade
    (GO:1900744)
  • Regulation of t-helper 17 type immune response
    (GO:2000316)
  • Regulation of t cell chemotaxis
    (GO:0010819)
  • Regulation of t cell differentiation in thymus
    (GO:0033081)
  • Response to interleukin-1
    (GO:0070555)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Signaling receptor binding
    (GO:0005102)
  • Toll-like receptor 2 signaling pathway
    (GO:0034134)
  • Toll-like receptor 3 signaling pathway
    (GO:0034138)
  • Toll-like receptor 4 signaling pathway
    (GO:0034142)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)

Other Information

Genular Protein ID: 940933381

Symbol: LEG9_RAT

Name: Galectin-9

UniProtKB Accession Codes:

P97840 O08588 O35866

Database IDs:

AGR 1 AlphaFoldDB 1 CDD 1 CTD 1 ChEBI 9 EMBL 3 GO 69 Gene3D 1 InParanoid 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TCDB 1 UniProtKB 2 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 9038233

Title: Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.

PubMed ID: 9038233

DOI: 10.1074/jbc.272.9.6078

PubMed ID: 8995305

Title: Molecular cloning and functional reconstitution of a urate transporter/channel.

PubMed ID: 8995305

DOI: 10.1074/jbc.272.1.617

PubMed ID: 25158758

Title: Astrocyte galectin-9 potentiates microglial TNF secretion.

PubMed ID: 25158758

DOI: 10.1186/s12974-014-0144-0

Sequence Information:

  • Length: 354
  • Mass: 39946
  • Checksum: 6574F960B2EAF37C
  • Sequence:
    • MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT GFSGNDIAFH 
FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKNFFVQ 
YSHRVPYHLV DTISVSGCLH LSFINFQNST AAPVQPVFST MQFSQPVQFP RMPKGRKQRT 
QGFQPALQAP VAQTIIHTVH SIPGQMLSTP GIPPMAYPTP AYTIPFFTSI PNGFYPSKSI 
NISGVVLPDA KRFHINLRCG GDIAFHLNPR FNEKVVVRNT QINNSWGPEE RSLPGRMPFN 
RGQSFSVWIL CEGHCFKVAV DGQHICEYYH RLKNLPDINT LEVAGDIQLT HVQT

Genular Protein ID: 456043815

Symbol: A6HH78_RAT

Name: N/A

UniProtKB Accession Codes:

A6HH78 Q6P7Q6

Database IDs:

Bgee 1 CDD 1 CTD 1 EMBL 2 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RGD 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 322
  • Mass: 36341
  • Checksum: CDD414A6FD1BA9DD
  • Sequence:
    • MAFFSTQPPY MNPVIPFTGI IQGGLQNGLQ ITLQGTVHPF PNRIAVNFQT GFSGNDIAFH 
FNPRFEEGGY VVCNTKQNGK WGPEERKMQM PFQKGMPFEL CFLVQRSEFK VMVNKNFFVQ 
YSHRVPYHLV DTISVSGCLH LSFINFQTQG FQPAHQAPVA QTIIHTVHSI PGQMLSTPGI 
PPMAYPTPAY TIPFFTSIPN GFYPSKSINI SGVVLPDAKR FHINLRCGGD IAFHLNPRFN 
EKVVVRNTQI NNSWGPEERS LPGRMPFNRG QSFSVWILCE GHCFKVAVDG QHICEYYHRL 
KNLPDINTLE VAGDIQLTHV QT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.