Nfkbia | ENSRNOG00000007390 | NCBI 25493

Details for: Nfkbia

Gene ID: 25493

Symbol: Nfkbia

Ensembl ID: ENSRNOG00000007390

Description: NFKB inhibitor alpha

Associated with

Activation of nf-kappab in b cells
(R-RNO-1169091)
Adaptive immune system
(R-RNO-1280218)
Cytokine signaling in immune system
(R-RNO-1280215)
Cytosolic sensors of pathogen-associated dna
(R-RNO-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-RNO-168928)
Death receptor signaling
(R-RNO-73887)
Deubiquitination
(R-RNO-5688426)
Downstream signaling events of b cell receptor (bcr)
(R-RNO-1168372)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Interleukin-1 family signaling
(R-RNO-446652)
Interleukin-1 signaling
(R-RNO-9020702)
Metabolism of proteins
(R-RNO-392499)
Myd88 cascade initiated on plasma membrane
(R-RNO-975871)
Myd88 dependent cascade initiated on endosome
(R-RNO-975155)
Myd88-independent tlr4 cascade
(R-RNO-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-RNO-166058)
Nf-kb is activated and signals survival
(R-RNO-209560)
P75 ntr receptor-mediated signalling
(R-RNO-193704)
P75ntr signals via nf-kb
(R-RNO-193639)
Post-translational protein modification
(R-RNO-597592)
Rip-mediated nfkb activation via zbp1
(R-RNO-1810476)
Signaling by interleukins
(R-RNO-449147)
Signaling by the b cell receptor (bcr)
(R-RNO-983705)
Signal transduction
(R-RNO-162582)
Sumo e3 ligases sumoylate target proteins
(R-RNO-3108232)
Sumoylation
(R-RNO-2990846)
Sumoylation of immune response proteins
(R-RNO-4755510)
Tak1-dependent ikk and nf-kappa-b activation
(R-RNO-445989)
Toll-like receptor cascades
(R-RNO-168898)
Toll like receptor 2 (tlr2) cascade
(R-RNO-181438)
Toll like receptor 3 (tlr3) cascade
(R-RNO-168164)
Toll like receptor 4 (tlr4) cascade
(R-RNO-166016)
Toll like receptor 5 (tlr5) cascade
(R-RNO-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-RNO-168181)
Toll like receptor 9 (tlr9) cascade
(R-RNO-168138)
Toll like receptor 10 (tlr10) cascade
(R-RNO-168142)
Toll like receptor tlr1:tlr2 cascade
(R-RNO-168179)
Toll like receptor tlr6:tlr2 cascade
(R-RNO-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-RNO-975138)
Traf6 mediated nf-kb activation
(R-RNO-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-RNO-937061)
Ub-specific processing proteases
(R-RNO-5689880)
Zbp1(dai) mediated induction of type i ifns
(R-RNO-1606322)
B cell receptor signaling pathway
(GO:0050853)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Cytoplasmic sequestering of nf-kappab
(GO:0007253)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Heat shock protein binding
(GO:0031072)
I-kappab/nf-kappab complex
(GO:0033256)
Identical protein binding
(GO:0042802)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Liver regeneration
(GO:0097421)
Molecular sequestering activity
(GO:0140313)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of notch signaling pathway
(GO:0045746)
Nf-kappab binding
(GO:0051059)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Notch signaling pathway
(GO:0007219)
Nuclear localization sequence binding
(GO:0008139)
Nucleotide-binding oligomerization domain containing 1 signaling pathway
(GO:0070427)
Nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070431)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein import into nucleus
(GO:0006606)
Protein sequestering activity
(GO:0140311)
Regulation of cell population proliferation
(GO:0042127)
Regulation of gene expression
(GO:0010468)
Response to ethanol
(GO:0045471)
Response to exogenous dsrna
(GO:0043330)
Response to lipopolysaccharide
(GO:0032496)
Response to muramyl dipeptide
(GO:0032495)
Response to muscle stretch
(GO:0035994)
Response to organic cyclic compound
(GO:0014070)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Transcription regulator inhibitor activity
(GO:0140416)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

NF-kappa-B inhibitor alpha

Genular Protein ID: 2564810129

Symbol: IKBA_RAT

Name: NF-kappa-B inhibitor alpha

UniProtKB Accession Codes:

Q63746 B2RYS5

Database IDs:

Citations:

PubMed ID: 1741294

Title: Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing Notch-like repeats.

PubMed ID: 1741294

DOI: 10.1093/nar/20.3.607

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1588976

Title: Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex.

PubMed ID: 1588976

DOI: 10.1128/mcb.12.6.2898-2908.1992

Sequence Information:

Length: 314
Mass: 35017
Checksum: CC4C9D0F6CDDA950
Sequence:

MFQPAGHGQD WAMEGPRDGL KKERLVDDRH DSGLDSMKDE DYEQMVKELR EIRLQPQEAP 
LAAEPWKQQL TEDGDSFLHL AIIHEEKTLT MEVIGQVKGD LAFLNFQNNL QQTPLHLAVI 
TNQPGIAEAL LKAGCDPELR DFRGNTPLHL ACEQGCLASV AVLTQTCTPQ HLHSVLQATN 
YNGHTCLHLA SIHGYLGIVE HLVTLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG 
ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQTL PESEDEESYD TESEFTEDEL 
PYDDCVFGGQ RLTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.