Notch1 | ENSRNOG00000019322 | NCBI 25496

Details for: Notch1

Gene ID: 25496

Symbol: Notch1

Ensembl ID: ENSRNOG00000019322

Description: notch receptor 1

Associated with

Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Atrioventricular node development
(GO:0003162)
Atrioventricular valve morphogenesis
(GO:0003181)
Auditory receptor cell fate commitment
(GO:0009912)
Axonogenesis
(GO:0007409)
Calcium-ion regulated exocytosis
(GO:0017156)
Calcium ion binding
(GO:0005509)
Cardiac atrium morphogenesis
(GO:0003209)
Cardiac chamber formation
(GO:0003207)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cardiac right atrium morphogenesis
(GO:0003213)
Cardiac right ventricle formation
(GO:0003219)
Cardiac ventricle morphogenesis
(GO:0003208)
Cell differentiation
(GO:0030154)
Cell differentiation in spinal cord
(GO:0021515)
Cell migration involved in endocardial cushion formation
(GO:0003273)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Compartment pattern specification
(GO:0007386)
Coronary sinus valve morphogenesis
(GO:0003182)
Coronary vein morphogenesis
(GO:0003169)
Determination of left/right symmetry
(GO:0007368)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Endocardial cushion development
(GO:0003197)
Endocardial cushion morphogenesis
(GO:0003203)
Endocardium development
(GO:0003157)
Endocardium morphogenesis
(GO:0003160)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Enzyme inhibitor activity
(GO:0004857)
Epidermal cell fate specification
(GO:0009957)
Epidermis development
(GO:0008544)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Foregut morphogenesis
(GO:0007440)
Gene expression
(GO:0010467)
Glial cell differentiation
(GO:0010001)
Growth involved in heart morphogenesis
(GO:0003241)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Inflammatory response to antigenic stimulus
(GO:0002437)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
In utero embryonic development
(GO:0001701)
Keratinocyte differentiation
(GO:0030216)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Luteolysis
(GO:0001554)
Mesenchymal cell development
(GO:0014031)
Mitral valve formation
(GO:0003192)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cell proliferation involved in heart valve morphogenesis
(GO:0003252)
Negative regulation of extracellular matrix constituent secretion
(GO:0003332)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of ossification
(GO:0030279)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube development
(GO:0021915)
Neuron differentiation
(GO:0030182)
Notch binding
(GO:0005112)
Notch signaling pathway
(GO:0007219)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
(GO:0003270)
Outflow tract morphogenesis
(GO:0003151)
Pericardium morphogenesis
(GO:0003344)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of transcription of notch receptor target
(GO:0007221)
Protein catabolic process
(GO:0030163)
Protein import into nucleus
(GO:0006606)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of cardioblast proliferation
(GO:0003264)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of notch signaling pathway
(GO:0008593)
Regulation of somitogenesis
(GO:0014807)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signaling receptor activity
(GO:0038023)
Spermatogenesis
(GO:0007283)
Sprouting angiogenesis
(GO:0002040)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription regulator activator activity
(GO:0140537)
Transmembrane signaling receptor activity
(GO:0004888)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Neurogenic locus notch homolog protein 1

Genular Protein ID: 1570775299

Symbol: NOTC1_RAT

Name: Neurogenic locus notch homolog protein 1

UniProtKB Accession Codes:

Q07008 F1M9E7

Database IDs:

Citations:

PubMed ID: 1764995

Title: A homolog of Drosophila Notch expressed during mammalian development.

PubMed ID: 1764995

DOI: 10.1242/dev.113.1.199

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 11182080

Title: Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.

PubMed ID: 11182080

DOI: 10.1016/s0896-6273(01)00179-9

PubMed ID: 1295745

Title: Notch2: a second mammalian Notch gene.

PubMed ID: 1295745

DOI: 10.1242/dev.116.4.931

PubMed ID: 11438922

Title: Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development.

PubMed ID: 11438922

DOI: 10.1002/cne.1059.abs

PubMed ID: 25700513

Title: Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

PubMed ID: 25700513

DOI: 10.1126/science.1261093

Sequence Information:

Length: 2531
Mass: 270822
Checksum: 3E61AE863AA237F2
Sequence:

MPRLLAPLLC LTLLPALAAR GLRCSQPSGT CLNGGRCEVA NGTEACVCSG AFVGQRCQDP 
SPCLSTPCKN AGTCYVVDHG GIVDYACSCP LGFSGPLCLT PLANACLANP CRNGGTCDLL 
TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFES SYICGCPPGF HGPTCRQDVN 
ECSQNPGLCR HGGTCHNEIG SYRCACRATH TGPHCELPYV PCSPSPCQNG GTCRPTGDTT 
HECACLPGFA GQNCEENVDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ 
LMPNACQNGG TCHNSHGGYN CVCVNGWTGE DCSENIDDCA SAACFQGATC HDRVASFYCE 
CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECALGA 
NPCEHAGKCL NTLGSFECQC LQGYTGPRCE IDVNECISNP CQNDATCLDQ IGEFQCICMP 
GYEGVYCEIN TDECASSPCL HNGRCVDKIN EFLCQCPKGF SGHLCQYDVD ECASTPCKNG 
AKCLDGPNTY TCVCTEGYTG THCEVDIDEC DPDPCHYGLC KDGVATFTCL CQPGYTGHHC 
ETNINECHSQ PCRHGGTCQD RDNYYLCLCL KGTTGPNCEI NLDDCASNPC DSGTCLDKID 
GYECACEPGY TGSMCNVNID ECAGSPCHNG GTCEDGIAGF TCRCPEGYHD PTCLSEVNEC 
NSNPCIHGAC RDGLNGYKCD CAPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR 
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCPLP YTGATCEVVL APCATSPCKN 
SGVCKESEDY ESFSCVCPTG WQGQTCEIDI NECVKSPCRH GASCQNTNGS YRCLCQAGYT 
GRNCESDIDD CRPNPCHNGG SCTDGVNAAF CDCLPGFQGA FCEEDINECA SNPCQNGANC 
TDCVDSYTCT CPTGFNGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQY 
DVNECDSRPC LHGGTCQDSY GTYKCTCPQG YTGLNCQNLV RWCDSAPCKN GGKCWQTNTQ 
YHCECRSGWT GFNCDVLSVS CEVAAQKRGI DVTLLCQHGG LCVDEEDKHY CHCQAGYTGS 
YCEDEVDECS PNPCQNGATC TDYLGGFSCK CVAGYHGSNC SEEINECLSQ PCQNGGTCID 
LTNTYKCSCP RGTQGVHCEI NVDDCHPPLD PASRSPKCFN NGTCVDQVGG YTCTCPPGFV 
GERCEGDVNE CLSNPCDPRG TQNCVQRVND FHCECRAGHT GRRCESVING CRGKPCRNGG 
VCAVASNTAR GFICRCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGSFTG 
PECQFPASSP CVGSNPCYNQ GTCEPTSESP FYRCLCPAKF NGLLCHILDY SFTGGAGRDI 
PPPQIEEACE LPECQEDAGN KVCNLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF 
SDGHCDSQCN SAGCLFDGFD CQLTEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD 
CAEHVPERLA AGTLVLVVLL PPDQLRNNSF HFLRELSHVL HTNVVFKRDA QGQQMIFPYY 
GREEELRKHP IKRSAVGWAT TSLLPGTNGG RQRRELDPMD IHGSIVYLEI DNRQCVQSSS 
QCFQSATDVA AFLGALASLG SLNIPYKIEA VKSETVEPPL PSQLHLMYVA AAAFVLLFFV 
GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA SDGALMDDNQ 
NEWGDEDLET KKFRFEEPVV LPDLDDQTDH RQWTQQHLDA ADLRVSAMAP TPPQGEVDAD 
CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL HNQTDRTGET 
ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL LRNRATDLDA 
RMHDGTTPLI LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN VDAAVVLLKN 
GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI AQERMHHDIV 
RLLDEYNLVR SPQLHGTALG GTPTLSPTLC SPNGYLGNLK SATQGKKARK PSTKGLACSS 
KEAKDLKARR KKSQDGKGCL LDSSSMLSPV DSLESPHGYL SDVASPPLLP SPFQQSPSMP 
LSHLPGMPDT HLGISHLNVA AKPEMAALAG GSRLAFEPPP PRLSHLPVAS SASTVLSTNG 
TGAMNFTVGA PASLNGQCEW LPRLQNGMVP SQYNPLRPGV TPGTLSTQAA GLQHGMMGPI 
HSSLSTNTLS PIIYQGLPNT RLATQPHLVQ TQQVQPQNLQ IQPQNLQPPS QPHLSVSSAA 
NGHLGRSFLS GEPSQADVQP LGPSSLPVHT ILPQESQALP TSLPSSMVPP MTTTQFLTPP 
SQHSYSSSPV DNTPSHQLQV PEHPFLTPSP ESPDQWSSSS PHSNISDWSE GISSPPTSMP 
SQITHIPEAF K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Notch1

Associated with

Other Information

A homolog of Drosophila Notch expressed during mammalian development. PubMed ID: 1764995

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. PubMed ID: 11182080

Notch2: a second mammalian Notch gene. PubMed ID: 1295745

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. PubMed ID: 11438922